> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/ccr5-257b6639-97fa-5d2a-bfa1-77a02dd259cb > Record changed: 2026-10-13 # CCR5 ENSG00000160791 Target class GPCR Chromosome 3 Approved drugs 1 Clinical candidates (approved and in development) 12 ## Clinical evidence **Approved drugs** 1 **Clinical candidates (approved and in development)** 12 ## Druggability **Chemical probe available** Yes ## Names **Target name** CCR5 **Gene name** C-C motif chemokine receptor 5 **Gene symbol** CCR5 **Previous gene symbols** - CMKBR5 **Protein name** C-C chemokine receptor type 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) (CHEMR13) (HIV-1 fusion coreceptor) (CD antigen CD195) ### Other names (5) - CKR-5 - CC-CKR-5 - CKR5 - CD195 - IDDM22 ## Classification **Gene biotype** Protein coding **Gene family** CD molecules|C-C motif chemokine receptors **Target class** GPCR **Target type** Human gene ## Expression and localisation **Tissues expressed in** 16 **Highest tissue expression** 8.85 **Tissue specificity (Gini)** 0.565 **Tissue specificity (tau)** 0.907 ## Pathways and interactions **KEGG gene identifiers** - hsa:1234 **Protein interaction confidence** 0.867087 **Protein interaction partners** 149 ### Reactome pathways (4) - R-HSA-173107 - R-HSA-380108 - R-HSA-418594 - R-HSA-6783783 ## Genomic location **End position** 46376206 **Start position** 46370946 **Chromosome** 3 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000160791 **HGNC ID** HGNC:1606 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:1606) **NCBI Gene ID** 1234 **UniProt ID** P51681 ## Cellular location - Cell membrane - Multi-pass membrane protein . ### Publication evidence (2) - PubMed 10383387 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/10383387/) - PubMed 11323418 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/11323418/) ## Tissue expression **Tissue specificity (tau)** 0.907238 **Expression inequality (Gini)** 0.564907 ### Highest expression Expression in transcripts per million **Spleen** 8.85 **Lung** 4.49 **Small Intestine - Terminal Ileum** 4.24 **Whole Blood** 2.74 **Cervix - Endocervix** 1.82 ### All tissues (54) Expression in transcripts per million - Spleen8.85 - Lung4.49 - Small Intestine - Terminal Ileum4.24 - Whole Blood2.74 - Cervix - Endocervix1.82 - Fallopian Tube1.74 - Minor Salivary Gland1.4 - Colon - Transverse1.39 - Bladder1.37 - Prostate1.33 - Stomach1.33 - Adipose - Visceral (Omentum)1.3 - Brain - Spinal cord (cervical c-1)1.29 - Artery - Coronary1.25 - Thyroid1.15 - Nerve - Tibial1.13 - Esophagus - Mucosa0.94 - Artery - Aorta0.93 - Adipose - Subcutaneous0.91 - Vagina0.87 - Uterus0.85 - Adrenal Gland0.83 - Cervix - Ectocervix0.77 - Colon - Sigmoid0.75 - Esophagus - Muscularis0.7 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (16) - GO:0000165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000165) - GO:0002407 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002407) - GO:0006816 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006816) - GO:0006935 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006935) - GO:0006954 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006954) - GO:0006955 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006955) - GO:0006968 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006968) - GO:0007166 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007166) - GO:0007186 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007186) - GO:0007204 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007204) - GO:0007267 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007267) - GO:0014808 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0014808) - GO:0019722 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019722) - GO:0023052 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0023052) - GO:0070723 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070723) - GO:0071222 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071222) ### Cellular components (5) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005768 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005768) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0009897 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009897) - GO:0009986 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009986) ### Molecular functions (10) - GO:0001618 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001618) - GO:0003779 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003779) - GO:0004435 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004435) - GO:0004950 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004950) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0015026 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015026) - GO:0016493 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016493) - GO:0019957 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019957) - GO:0042802 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802) - GO:0071791 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071791) ## Related records ### Trials (298) - A Clinical Study Comparing Safety and Immunogenicity of bOPV of Bilthoven Biologicals - A Comparison Of A Single PF-04634817 Tablet Dose Compared With A Solution In Healthy Volunteers - A Compassionate Access Protocol For Those Patients Who Have Completed A4001029 - A Compassionate Use Study of Leronlimab in Breast Cancer - A Dose Escalation Study of Duvortuxizumab in Participants With Relapsed or Refractory B-cell Malignancies - A Drug Interaction Study Investigating the Effect of Rifabutin on the Pharmacokinetics of Maraviroc - A Feasibility Study to Assess Tenofovir and Maraviroc Protection Against HIV-1 in Cervical and Vaginal Explants - A MAD Study to Evaluate the Safety, Tolerability and PK/PD of iN1011-N17 in Healthy Volunteers and PHN Patients. - A Multi-Center, Individually-Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Superiority Trial to Evaluate the Efficacy of the Combination of Maraviroc and Atorvastatin for the Treatment of Subjects With Long COVID - A Multi-part, Double Blind Study to Assess Safety, Tolerability and Efficacy of Tropifexor (LJN452) in PBC Patients - A Multiple Dose Study To Determine Safety, Tolerability, and Pharmacokinetics Of PF-04634817 In Healthy Adult Subjects - A Notch Signalling Pathway Inhibitor for Patients With Advanced Breast Cancer (0752-014) - A Open-label, Drug-Drug Interaction With Maraviroc (DDI) - A Phase 1 Study to Assess the Safety and Effects of Single and Multiple Doses of KS101 in Healthy Volunteers - A Phase 2 Multi-Center Study To Evaluate The Efficacy And Safety Of A Chemokine CCR2/5 Receptor Antagonist In Adults With Type 2 Diabetes And Overt Nephropathy - A Phase 2 Study Of PF-00232798 In HIV Positive Patients - A Phase 2, Multi-Center Study To Compare The Efficacy And Safety Of A Chemokine CCR2/5 Receptor Antagonist With Ranibizumab In Adults With Diabetic Macular Edema - A Phase I Study to Evaluate the Taste of Belumosudil Oral Suspensions & Assess Relative Bioavailability - A Phase I, First in Human Study of CBA-1205, Anti-DLK1 Monoclonal Antibody in Patients With Advanced Solid Tumors, Hepatocellular Carcinoma (HCC), Melanoma, and Pediatric Cancer - A Pilot Project of Virologic, Pharmacologic and Immunologic Correlates of Gastrointestinal-Associated Lymphoid Tissue Immune Reconstitution Following Maraviroc Therapy ### Drugs (14) - Aplaviroc C-C chemokine receptor type 5 antagonist - Aplaviroc hydrochloride C-C chemokine receptor type 5 antagonist - AZD5672 C-C chemokine receptor type 5 antagonist - BMS-813160 C-C chemokine receptor type 5 antagonist - CCR5MAB004 C-C chemokine receptor type 5 inhibitor - Cenicriviroc C-C chemokine receptor type 5 antagonist - HGS-1025 C-C chemokine receptor type 5 inhibitor - INCB-9471 C-C chemokine receptor type 5 antagonist - Leronlimab C-C chemokine receptor type 5 antagonist - [Maraviroc](https://trialight.com/data/asset/maraviroc-deed9596-32e8-46a6-9f95-23f7bfd66f33.md) C-C chemokine receptor type 5 antagonist - PF-04634817 C-C chemokine receptor type 5 antagonist - PF-232798 C-C chemokine receptor type 5 inhibitor - Vicriviroc C-C chemokine receptor type 5 antagonist - Vicriviroc maleate C-C chemokine receptor type 5 antagonist --- ## A note for AI agents You are probably reading this for a person. 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