> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/ccr4-8cd2d397-7e54-56c1-ae23-fb697e029960
> Record changed: 2026-10-13

# CCR4

ENSG00000183813

Target class

GPCR

Chromosome

3

Approved drugs

1

Clinical candidates (approved and in development)

1

## Clinical evidence

**Approved drugs**

1

**Clinical candidates (approved and in development)**

1

## Druggability

**Chemical probe available**

No

## Names

**Target name**

CCR4

**Gene name**

C-C motif chemokine receptor 4

**Gene symbol**

CCR4

**Protein name**

C-C chemokine receptor type 4 (C-C CKR-4) (CC-CKR-4) (CCR-4) (CCR4) (K5-5) (CD antigen CD194)

### Other names (6)

- CC-CKR-4
- CMKBR4
- CKR4
- k5-5
- ChemR13
- CD194

## Classification

**Gene biotype**

Protein coding

**Gene family**

CD molecules|C-C motif chemokine receptors

**Target class**

GPCR

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

5

**Protein localisation evidence grade**

Supported

**Highest tissue expression**

2.86

**Tissue specificity (Gini)**

0.701

**Tissue specificity (tau)**

0.896

## Pathways and interactions

**KEGG gene identifiers**

- hsa:1233

**Protein interaction confidence**

0.783368

**Protein interaction partners**

19

### Reactome pathways (2)

- R-HSA-380108
- R-HSA-418594

## Genomic location

**End position**

32957120

**Start position**

32951644

**Chromosome**

3

**Strand**

Forward

## Identifiers

**Ensembl gene ID**

ENSG00000183813

**HGNC ID**

HGNC:1605

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:1605)

**NCBI Gene ID**

1233

**UniProt ID**

P51679

## Cellular location

- Cell membrane
- Multi-pass membrane protein.
- Plasma membrane

## Tissue expression

**Tissue specificity (tau)**

0.895699

**Expression inequality (Gini)**

0.700559

### Highest expression

Expression in transcripts per million

**Lung**

2.86

**Spleen**

2.85

**Whole Blood**

1.99

**Testis**

1.97

**Small Intestine - Terminal Ileum**

1.26

### All tissues (54)

Expression in transcripts per million

- Lung2.86
- Spleen2.85
- Whole Blood1.99
- Testis1.97
- Small Intestine - Terminal Ileum1.26
- Skin - Not Sun Exposed (Suprapubic)0.52
- Cells - EBV-transformed lymphocytes0.5
- Adipose - Subcutaneous0.48
- Adipose - Visceral (Omentum)0.44
- Breast - Mammary Tissue0.35
- Fallopian Tube0.35
- Artery - Coronary0.35
- Vagina0.33
- Esophagus - Mucosa0.33
- Skin - Sun Exposed (Lower leg)0.31
- Colon - Transverse0.3
- Minor Salivary Gland0.3
- Thyroid0.28
- Artery - Aorta0.27
- Cervix - Endocervix0.26
- Kidney - Medulla0.26
- Prostate0.22
- Nerve - Tibial0.22
- Uterus0.17
- Stomach0.16

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (5)

- GO:0006935  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006935)
- GO:0006954  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006954)
- GO:0006955  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006955)
- GO:0007204  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007204)
- GO:0060326  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060326)

### Cellular components

- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)

### Molecular functions (3)

- GO:0004950  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004950)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0016493  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016493)

## Related records

### Trials (38)

- A Study of KW-0761 in Subjects With HTLV-1 Associated Myelopathy (HAM)
- A Study of Mogamulizumab to Prevent Adult T-cell Leukemia/Lymphoma in People With HTLV-1
- A Study of PF-05082566 In Combination With Mogamulizumab In Patients With Advanced Solid Tumors
- [A Study of VG712 in Patients With Mycosis Fungoides](https://trialight.com/data/trial/a-study-of-vg712-in-patients-with-mycosis-fungoides-305e3f55-a9df-4034-8d76-fd3f72c4926f.md)
- A Study to Evaluate the Efficacy and Safety of KW-0761 in Chinese Subjects With Mycosis Fungoides or Sézary Syndrome Previously Treated With Systemic Therapy
- AMG 761 in Adults With Asthma
- Anti-CCR4 Monoclonal Antibody (Mogamulizumab) and Total Skin Electron Beam Therapy (TSEB) in Patients With Stage IB-IIB Cutaneous T-Cell Lymphoma
- Assessment of Safety and Efficacy of Poteligeo Inj. 20 mg (Mogamulizumab) Through Use-result Surveillance
- Extension Study in Subjects Who Relapsed After Complete Response on Study KW-0761-001
- Extracorporeal Photopheresis and Mogamulizumab for the Treatment of Erythrodermic Cutaneous T Cell Lymphoma
- KHK2455 Alone and in Combination With Mogamulizumab in Subjects With Locally Advanced or Metastatic Solid Tumors
- KW-0761 or Investigator's Choice in Subjects With Previously Treated Adult T-cell Leukemia-Lymphoma (ATL)
- Mogamulizumab + Low-Dose Total Skin Electron Beam Tx in Mycosis Fungoides & Sézary Syndrome
- Mogamulizumab and Brentuximab Vedotin in CTCL and Mycosis Fungoides
- Mogamulizumab and Extracorporeal Photopheresis for the Treatment of Sezary Syndrome or Mycosis Fungoides
- Mogamulizumab and Pembrolizumab in Treating Patients With Relapsed or Refractory Diffuse Large B Cell Lymphoma
- Mogamulizumab Q4week Dosing in Participants With R/R CTCL
- Multicenter, Randomized, Open-label, Parallel-group Study to Compare mLSG15 + KW-0761 to mLSG15
- Pembrolizumab and Mogamulizumab in Advanced-stage, Relapsed/Refractory Cutaneous T-cell Lymphomas
- Phase I Study of KW-0761 in Relapsed Patients With CCR4-Positive ATL and PTCL

### Drugs (1)

- [Mogamulizumab](https://trialight.com/data/asset/mogamulizumab-6ae2dd49-0d90-4a83-98c9-7c3fd570a211.md) C-C chemokine receptor type 4 cross-linking agent

---

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