> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/ccnd1-5f6a6270-9aec-5f1d-9fd9-19c16cfaf816 > Record changed: 2026-10-13 # CCND1 ENSG00000110092 Target class Other cytosolic protein Chromosome 11 Approved drugs 1 Clinical candidates (approved and in development) 2 ## Clinical evidence **Approved drugs** 1 **Clinical candidates (approved and in development)** 2 ## Druggability **Chemical probe available** No ## Names **Other names** - U21B31 **Target name** CCND1 **Gene name** Cyclin D1 **Gene symbol** CCND1 **Protein name** G1/S-specific cyclin-D1 (B-cell lymphoma 1 protein) (BCL-1) (BCL-1 oncogene) (PRAD1 oncogene) ### Previous gene symbols (3) - BCL1 - D11S287E - PRAD1 ## Classification **Gene biotype** Protein coding **Gene family** Cyclins **Target class** Other cytosolic protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 53 **Protein localisation evidence grade** Supported **Highest tissue expression** 202 **Tissue specificity (Gini)** 0.48 **Tissue specificity (tau)** 0.837 ## Pathways and interactions **KEGG gene identifiers** - hsa:595 **Protein interaction confidence** 0.833133 **Protein interaction partners** 173 ### Reactome pathways (18) - R-HSA-187577 - R-HSA-1912408 - R-HSA-3214858 - R-HSA-6785807 - R-HSA-69231 - R-HSA-75815 - R-HSA-8849470 - R-HSA-8853884 - R-HSA-8878166 - R-HSA-8934593 - R-HSA-8951430 - R-HSA-8951936 - R-HSA-9018519 - R-HSA-9634638 - R-HSA-9661069 - R-HSA-9754119 - R-HSA-9825892 - R-HSA-9929491 ## Genomic location **End position** 69654474 **Start position** 69641143 **Chromosome** 11 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000110092 **HGNC ID** HGNC:1582 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:1582) **NCBI Gene ID** 595 **UniProt ID** P24385 ## Cellular location - Nucleus . Cytoplasm . Nucleus membrane . Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members. . - Nucleoplasm ### Publication evidence (4) - PubMed 20399237 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/20399237/) - PubMed 29279382 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/29279382/) - PubMed 40307251 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/40307251/) - PubMed 9106657 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/9106657/) ## Tissue expression **Tissue specificity (tau)** 0.837173 **Expression inequality (Gini)** 0.479934 ### Highest expression Expression in transcripts per million **Cells - Cultured fibroblasts** 202 **Skin - Not Sun Exposed (Suprapubic)** 110.9 **Skin - Sun Exposed (Lower leg)** 102.19 **Esophagus - Mucosa** 96.55 **Nerve - Tibial** 94.81 ### All tissues (54) Expression in transcripts per million - Cells - Cultured fibroblasts202 - Skin - Not Sun Exposed (Suprapubic)110.9 - Skin - Sun Exposed (Lower leg)102.19 - Esophagus - Mucosa96.55 - Nerve - Tibial94.81 - Artery - Aorta87.22 - Vagina71.69 - Prostate71.53 - Artery - Tibial70.17 - Artery - Coronary64.45 - Lung62.14 - Adipose - Subcutaneous59.56 - Breast - Mammary Tissue56 - Thyroid50.63 - Minor Salivary Gland44.5 - Esophagus - Muscularis41.26 - Pituitary40.99 - Esophagus - Gastroesophageal Junction33.37 - Kidney - Medulla30.3 - Bladder30.28 - Adipose - Visceral (Omentum)28.02 - Adrenal Gland27.44 - Heart - Atrial Appendage27.38 - Colon - Sigmoid26.71 - Liver25.71 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (8) - GO:0000082 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000082) - GO:0000122 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000122) - GO:0006974 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006974) - GO:0009410 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009410) - GO:0010971 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010971) - GO:0031571 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031571) - GO:0044321 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0044321) - GO:0070141 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070141) ### Cellular components (7) - GO:0000307 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000307) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005654 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0017053 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0017053) - GO:0031965 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031965) ### Molecular functions (8) - GO:0003714 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003714) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0019899 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019899) - GO:0019901 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019901) - GO:0042826 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042826) - GO:0043539 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043539) - GO:0061575 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0061575) - GO:0070064 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070064) ## Off-target safety - regulation of transcription factor activity ### Studies (2) - cell-based: LTEA\_HepaRG\_CCND1is one of 100 assay component(s) measured in the LTEA HepaRG cell culture assay. It is a marker of Cell proliferation, survival, death. - cell-based: LTEA\_HepaRG\_CCND1is one of 100 assay component(s) measured in the LTEA HepaRG cell culture assay. It is a marker of Cell proliferation, survival, death. ### Biological samples - HepaRG, cell line Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) ## Related records ### Trials (364) - "Neo-Adjuvant Treatment With Palbociclib: Effect on Ki67 and Apoptosis Before, During and After Treatment " - A Biomarker Study of Palbociclib + Fulvestrant for Second, and Third Line of Postmenopausal Women With hr+/her2- Advanced Breast Cancer - A Clinical Research Study to Determine Whether PD 0332991 May Be Effective in Treating Patients With Liver Cancer - A Comparative Study of AZD9833 Plus Palbociclib Versus Anastrozole Plus Palbociclib in Patients With ER-Positive HER2 Negative Breast Cancer Who Have Not Received Any Systemic Treatment for Advanced Disease - A Drug-Drug Interaction Study To Investigate The Potential For Multiple Doses Of Palbociclib (PD-0332991) To Alter The Pharmacokinetics Of Oral Midazolam In Adult Healthy Women of Non-Childbearing Potential. - [A First-in-human Dose Escalation and Expansion Study to Evaluate the Safety, and Tolerability of AZD8421 Alone or in Combination in Participants With Selected Advanced or Metastatic Solid Tumors](https://trialight.com/data/trial/a-first-in-human-dose-escalation-and-expansion-study-to-e30c8326-67cd-4bf8-80bf-5c8c78451254.md) - A First-in-Human Study of D-0502 Alone and in Combination With Palbociclib in Women With Advanced or Metastatic ER-Positive and HER2-Negative Breast Cancer - A Open Label Study of the Efficacy and Safety of PD0332991 a Selective Inhibitor of the Cyclin Dependent Kinases 4 and 6 in Patients With Recurrent Ovarian Cancer Demonstrating Rb-proficiency and Low p16 Expression - [A Phase 1 Study of BMS-986500 as Monotherapy or Combination Therapy in Advanced Solid Tumors](https://trialight.com/data/trial/a-phase-1-study-of-bms-986500-as-monotherapy-or-combination-d34969aa-e987-4889-910e-0aea7d91d410.md) - A Phase 1 Study of Oral OP-1250 in Combination With Palbociclib in HR+/HER2- Breast Cancer Patients - A Phase 1 Trial of TST of PD 0332991 Followed by Cytarabine and Mitoxantrone for Adults With Relapsed and Refractory Acute Leukemias and High-Risk Myelodysplasia - A Phase 1/2 Trial of ARV-471 Alone and in Combination With Palbociclib (IBRANCE®) in Patients With ER+/HER2- Locally Advanced or Metastatic Breast Cancer - A Phase I Clinical Study on SHR6390 in Healthy Chinese Volunteers - A Phase Ib/II Study to Evaluate Multiple Combination Therapies of FWD1802 in Patients With ER+/HER2- BC - A Phase II Randomized Study Evaluating the Biological and Clinical Effects of the Combination of Palbociclib With Letrozole as Neoadjuvant Therapy in Post-Menopausal Women With Estrogen-Receptor Positive Primary Breast Cancer - A Phase II Study of Androgen Deprivation Therapy With or Without Palbociclib in RB-Positive Metastatic Prostate Cancer - A Phase II Study of Palbociclib for Recurrent or Refractory Advanced Thymic Epithelial Tumor - A Pilot Study To Investigate The Effect Of Concurrent Antacid Administration On The Bioavailability Of Six Experimental Formulations Of Palbociclib - A Randomized Study Comparing the Immune Modulation Effect of Ribociclib, Palbociclib, and Abemaciclib in ER+/HER2- EBC - A Randomized, Open-label, Multi-center Phase IV Study Evaluating Palbociclib Plus Endocrine Treatment Versus a Chemotherapy-based Treatment Strategy in Patients With Hormone Receptor Positive / HER2 Negative Breast Cancer in a Real World Setting (GBG 93 - PADMA Study). ### Drugs (2) - Briciclib G1/S-specific cyclin D1 inhibitor - [Palbociclib](https://trialight.com/data/asset/palbociclib-2686787c-5f11-4b65-9a5b-549fcd2af644.md) CDK6/cyclin D1 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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