> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/ccdc6-65c1e338-cfad-5b3b-bac5-7451754b794f
> Record changed: 2026-10-13

# CCDC6

ENSG00000108091

Target class

Unclassified protein

Chromosome

10

Approved drugs

2

Clinical candidates (approved and in development)

2

## Clinical evidence

**Approved drugs**

2

**Clinical candidates (approved and in development)**

2

## Druggability

**Chemical probe available**

No

## Names

**Target name**

CCDC6

**Gene name**

Coiled-coil domain containing 6

**Gene symbol**

CCDC6

**Protein name**

Coiled-coil domain-containing protein 6 (Papillary thyroid carcinoma-encoded protein) (Protein H4)

### Other names (4)

- PTC
- TPC
- H4
- PTC1

### Previous gene symbols (2)

- TST1
- D10S170

## Classification

**Gene biotype**

Protein coding

**Target class**

Unclassified protein

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

54

**Protein localisation evidence grade**

Supported

**Highest tissue expression**

57.82

**Tissue specificity (Gini)**

0.284

**Tissue specificity (tau)**

0.544

## Pathways and interactions

**KEGG gene identifiers**

- hsa:8030

**Protein interaction confidence**

0.8305

**Protein interaction partners**

14

## Genomic location

**End position**

59907029

**Start position**

59788747

**Chromosome**

10

**Strand**

Reverse

## Identifiers

**Ensembl gene ID**

ENSG00000108091

**HGNC ID**

HGNC:18782

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:18782)

**NCBI Gene ID**

8030

**UniProt ID**

Q16204

## Cellular location

- Cytoplasm. Cytoplasm, cytoskeleton . Note=May be a cytoskeletal protein.
- Cytosol

## Tissue expression

**Tissue specificity (tau)**

0.543975

**Expression inequality (Gini)**

0.284486

### Highest expression

Expression in transcripts per million

**Artery - Tibial**

57.82

**Artery - Aorta**

56.61

**Uterus**

55.15

**Esophagus - Mucosa**

51.05

**Vagina**

49.91

### All tissues (54)

Expression in transcripts per million

- Artery - Tibial57.82
- Artery - Aorta56.61
- Uterus55.15
- Esophagus - Mucosa51.05
- Vagina49.91
- Skin - Sun Exposed (Lower leg)49.16
- Colon - Sigmoid47.15
- Skin - Not Sun Exposed (Suprapubic)45.57
- Cervix - Ectocervix43.05
- Minor Salivary Gland39.49
- Artery - Coronary38.86
- Cervix - Endocervix36.7
- Esophagus - Muscularis35.29
- Cells - Cultured fibroblasts35.02
- Bladder34.91
- Fallopian Tube33.57
- Brain - Nucleus accumbens (basal ganglia)31.94
- Prostate31.81
- Thyroid30.78
- Lung30.24
- Cells - EBV-transformed lymphocytes29.98
- Esophagus - Gastroesophageal Junction28.64
- Brain - Frontal Cortex (BA9)28.41
- Breast - Mammary Tissue26.53
- Colon - Transverse26.12

And 29 more, listed on the interactive page.

## Biological functions

### Cellular components

- GO:0005829  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829)

### Molecular functions (3)

- GO:0005200  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005200)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0042802  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802)

## Related records

### Trials (60)

- A Drug Drug Interaction (DDI) Study of Selpercatinib (LY3527723) and Rosuvastatin in Healthy Participants
- A Drug Drug Interaction (DDI) Study of Selpercatinib and Dabigatran in Healthy Participants
- A Real-world Study of Pralsetinib Combined With Leucogen in the Treatment of RET Fusion-positive NSCLC
- A Relative Bioavailability Study of Selpercatinib (LY3527723) in Healthy Participants
- A Retrospective and Prospective Real-world Study of Molecular Typing in the Treatment of Advanced Thyroid Cancer
- [A Study Comparing Two Formulations of Selpercatinib (LY3527723) in Healthy Participants](https://trialight.com/data/trial/a-study-comparing-two-formulations-of-selpercatinib-e64a5afd-5fd1-46a1-99a7-f6ffaa52b3aa.md)
- A Study Evaluating Targeted Therapies in Participants Who Have Advanced Solid Tumors With Genomic Alterations or Protein Expression Patterns Predictive of Response
- A Study of Absorption, Metabolism, Excretion, and Absolute Bioavailability of Carbon-14-Labelled \[14C\] Selpercatinib (LY3527723) in Healthy Male Participants
- A Study of Effect of Food and a Proton Pump Inhibitor on Selpercatinib (LY3527723) in Healthy Participants
- A Study of Effect of Selpercatinib (LY3527723) in Participants With Normal and Impaired Renal Function
- A Study of Effect of Selpercatinib (LY3527723) on Corrected QT (QTc) Interval in Healthy Participants
- A Study of Effects of Itraconazole and Rifampin on Selpercatinib (LY3527723) in Healthy Participants
- A Study of Effects of Selpercatinib (LY3527723) on Midazolam in Healthy Participants
- A Study of Effects of Selpercatinib (LY3527723) on Repaglinide in Healthy Participants
- A Study of Effects of Selpercatinib in Hepatically Impaired Participants and Healthy Participants
- A Study of Multiple Therapies in Biomarker-selected Participants With Resectable Stages IB-III Non-small Cell Lung Cancer (NSCLC)
- A Study of Oral LOXO-292 (Selpercatinib) in Pediatric Participants With Advanced Solid or Primary Central Nervous System (CNS) Tumors
- A Study of Pralsetinib Versus Standard of Care (SOC) for Treatment of RET-Mutated Medullary Thyroid Cancer (MTC).
- A Study of Pralsetinib Versus Standard of Care for First-Line Treatment of Advanced Non-Small Cell Lung Cancer (NSCLC)
- A Study of Selpercatinib (LOXO-292) in Participants With Advanced Solid Tumors, RET Fusion-Positive Solid Tumors, and Medullary Thyroid Cancer (LIBRETTO-001)

### Drugs (2)

- Pralsetinib Coiled-coil domain-containing protein 6/Tyrosine-protein kinase receptor RET inhibitor
- [Selpercatinib](https://trialight.com/data/asset/selpercatinib-b5343bcc-f751-4491-a1dd-3c8536f333da.md) Coiled-coil domain-containing protein 6/Tyrosine-protein kinase receptor RET inhibitor

---

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