> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/calcrl-ab682234-2bfa-51bd-a9eb-e0d3e9a4ee16
> Record changed: 2026-10-13

# CALCRL

ENSG00000064989

Target class

GPCR

Chromosome

2

Approved drugs

7

Clinical candidates (approved and in development)

12

## Clinical evidence

**Approved drugs**

7

**Clinical candidates (approved and in development)**

12

## Druggability

**Chemical probe available**

No

## Names

**Target name**

CALCRL

**Gene name**

Calcitonin receptor like receptor

**Gene symbol**

CALCRL

**Protein name**

Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) (CRLR)

### Other names (2)

- CGRPR
- CRLR

## Classification

**Gene biotype**

Protein coding

**Gene family**

Calcitonin receptors

**Target class**

GPCR

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

52

**Protein localisation evidence grade**

Supported

**Highest tissue expression**

66.75

**Tissue specificity (Gini)**

0.543

**Tissue specificity (tau)**

0.886

## Pathways and interactions

**KEGG gene identifiers**

- hsa:10203

**Protein interaction confidence**

0.92925

**Protein interaction partners**

16

### Reactome pathways (3)

- R-HSA-418555
- R-HSA-419812
- R-HSA-9856530

## Genomic location

**End position**

187448506

**Start position**

187341946

**Chromosome**

2

**Strand**

Reverse

## Identifiers

**Ensembl gene ID**

ENSG00000064989

**HGNC ID**

HGNC:16709

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:16709)

**NCBI Gene ID**

10203

**UniProt ID**

Q16602

## Cellular location

- Cell membrane
- Multi-pass membrane protein .
- Plasma membrane

### Publication evidence (2)

- PubMed 30115739  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/30115739/)
- PubMed 32296767  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/32296767/)

## Tissue expression

**Tissue specificity (tau)**

0.886371

**Expression inequality (Gini)**

0.543293

### Highest expression

Expression in transcripts per million

**Lung**

66.75

**Artery - Coronary**

31.86

**Adipose - Visceral (Omentum)**

29.95

**Thyroid**

28.41

**Adipose - Subcutaneous**

26.72

### All tissues (54)

Expression in transcripts per million

- Lung66.75
- Artery - Coronary31.86
- Adipose - Visceral (Omentum)29.95
- Thyroid28.41
- Adipose - Subcutaneous26.72
- Artery - Tibial22.85
- Breast - Mammary Tissue20.25
- Uterus17.69
- Nerve - Tibial14.99
- Cervix - Endocervix13.09
- Ovary11.19
- Cervix - Ectocervix10.44
- Minor Salivary Gland9.93
- Fallopian Tube9.74
- Artery - Aorta9.54
- Heart - Atrial Appendage7.83
- Esophagus - Gastroesophageal Junction7.78
- Vagina7.71
- Bladder7.47
- Prostate7.1
- Esophagus - Muscularis6.1
- Esophagus - Mucosa6.01
- Small Intestine - Terminal Ileum5.78
- Colon - Sigmoid5.29
- Brain - Spinal cord (cervical c-1)5.04

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (9)

- GO:0001525  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001525)
- GO:0006816  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006816)
- GO:0007187  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007187)
- GO:0007189  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007189)
- GO:0015031  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015031)
- GO:0031623  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031623)
- GO:0071329  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071329)
- GO:1990408  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1990408)
- GO:1990410  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1990410)

### Cellular components (7)

- GO:0005737  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737)
- GO:0005764  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005764)
- GO:0005768  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005768)
- GO:0005783  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005783)
- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)
- GO:1903143  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1903143)
- GO:1990406  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1990406)

### Molecular functions (5)

- GO:0001605  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001605)
- GO:0001635  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001635)
- GO:0004930  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004930)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:1990409  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1990409)

## On-target safety

- decreased blood phosphate  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased blood phosphate  
### Biological samples (4)

  - nervous system
  - cardiovascular
  - gastrointestinal
  - blood  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased blood pressure  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: increased blood pressure  
### Biological samples (4)

  - nervous system
  - cardiovascular
  - gastrointestinal
  - blood  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased heart rate  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: increased heart rate  
### Biological samples (4)

  - nervous system
  - cardiovascular
  - gastrointestinal
  - blood  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased gastric emptying  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased gastric emptying  
### Biological samples (4)

  - nervous system
  - cardiovascular
  - gastrointestinal
  - blood  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased blood pressure  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased blood pressure  
### Biological samples (4)

  - nervous system
  - cardiovascular
  - gastrointestinal
  - blood  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased blood glucose  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: increased blood glucose  
### Biological samples (4)

  - nervous system
  - cardiovascular
  - gastrointestinal
  - blood  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased cardiac contractility  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: increased cardiac contractility  
### Biological samples (4)

  - nervous system
  - cardiovascular
  - gastrointestinal
  - blood  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased pain  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: increased pain  
### Biological samples (4)

  - nervous system
  - cardiovascular
  - gastrointestinal
  - blood  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased pain  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: decreased pain  
### Biological samples (4)

  - nervous system
  - cardiovascular
  - gastrointestinal
  - blood  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased blood calcium  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased blood calcium  
### Biological samples (4)

  - nervous system
  - cardiovascular
  - gastrointestinal
  - blood  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- facial flushing  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: facial flushing  
### Biological samples (4)

  - nervous system
  - cardiovascular
  - gastrointestinal
  - blood  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)

## Related records

### Trials (192)

- 12-Week Placebo-controlled Study of Atogepant for the Preventive Treatment of Migraine in Participants With Episodic Migraine
- A Clinical Trial of Rimegepant for Vestibular Migraine Evaluation: Pre-experiment
- A Comparison of Nurtec ODT to Maxalt MLT-ODT in Adult ED Patients With Migraine Headache
- A Controlled Trial of Erenumab in Migraine Prevention
- A Dose-Finding Study of MK-1602 in the Treatment of Acute Migraine (MK-1602-006)
- A Dose-Finding Study of MK0974 in Acute Migraine (MK0974-004)
- A Functional MRI Study on Erenumab Treatment Effects in Episodic Migraine Patients
- A Long-Term Safety and Tolerability Extension Study Evaluating Atogepant for the Prevention of Chronic or Episodic Migraine
- A Pharmacokinetic Study of MK-1602 in the Treatment of Acute Migraine (MK-1602-007)
- A Prospective Real World Study of Rimegepant in the Treatment of Migraine
- A Prospective, Open-Label Study Evaluating the Effectiveness of Gepants for Acute Treatment of Migraine in the Emergency Department
- A Randomized, Open-Label, Multi-Center Study of Vestibular Migraine Prevention: Rimegepant Versus Flunarizine Non-inferiority Study
- A Registry Study on Rimegepant for the Treatment of Migraine Participants in Guangdong-Hong Kong-Macao Greater Bay Area
- A Safety and Efficacy Study to Evaluate AMG 334 in Migraine Prevention
- A Study Evaluating Oral Atogepant for the Prevention of Migraine in Japanese Participants With Chronic or Episodic Migraine
- A Study of Galcanezumab (LY2951742) in Adult Participants With Episodic Migraine
- A Study of Gastric Delay in Migraine Patients (3207-003)
- A Study of Gastrointestinal Emptying Time in Adult Participants With Migraine Before and After Start of a mAb CGRP Antagonist
- A Study of Oral Atogepant Tablets to Assess Adverse Events and Change in Disease Activity To Prevent Migraine in Participants Aged 12 to 17 Years
- A Study to Assess the Adverse Events and Change in Disease Activity of Oral Atogepant Tablets in Pediatric Participants (6-17 Years of Age) With Episodic Migraine

### Drugs (12)

- [Atogepant](https://trialight.com/data/asset/atogepant-06c1e020-1758-4b06-8f37-1c53649d9a0b.md) Calcitonin gene-related peptide type 1 receptor antagonist
- BI-44370 Calcitonin gene-related peptide type 1 receptor antagonist
- Davalintide Calcitonin gene-related peptide type 1 receptor agonist
- Erenumab Calcitonin gene-related peptide type 1 receptor antagonist
- MK3207 Calcitonin gene-related peptide type 1 receptor antagonist
- Olcegepant Calcitonin gene-related peptide type 1 receptor antagonist
- Rimegepant Calcitonin gene-related peptide type 1 receptor antagonist
- Rimegepant sulfate Calcitonin gene-related peptide type 1 receptor antagonist
- Telcagepant Calcitonin gene-related peptide type 1 receptor antagonist
- [Ubrogepant](https://trialight.com/data/asset/ubrogepant-8361e028-0d26-4b8f-97d3-849085bb72c3.md) Calcitonin gene-related peptide type 1 receptor antagonist
- Zavegepant Calcitonin-gene-related peptide receptor, CALCRL/RAMP1 antagonist
- [Zavegepant hydrochloride](https://trialight.com/data/asset/zavegepant-hydrochloride-d2e0be92-6d36-4681-8b60-b6cf5492ea41.md) Calcitonin gene-related peptide type 1 receptor antagonist

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