> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/cacng8-dca6a892-9d28-549d-97bb-5a7e9cb7b6e6 > Record changed: 2026-10-13 # CACNG8 ENSG00000142408 Target class Auxiliary transport protein Chromosome 19 Approved drugs 6 Clinical candidates (approved and in development) 9 ## Clinical evidence **Approved drugs** 6 **Clinical candidates (approved and in development)** 9 ## Druggability **Chemical probe available** No ## Names **Target name** CACNG8 **Gene name** Calcium voltage-gated channel auxiliary subunit gamma 8 **Gene symbol** CACNG8 **Protein name** Voltage-dependent calcium channel gamma-8 subunit (Neuronal voltage-gated calcium channel gamma-8 subunit) (Transmembrane AMPAR regulatory protein gamma-8) (TARP gamma-8) ## Classification **Gene biotype** Protein coding **Gene family** Calcium channel auxiliary gamma subunits|MicroRNA protein coding host genes **Target class** Auxiliary transport protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 16 **Highest tissue expression** 39.37 **Tissue specificity (Gini)** 0.835 **Tissue specificity (tau)** 0.918 ## Pathways and interactions **KEGG gene identifiers** - hsa:59283 **Protein interaction confidence** 0.822429 **Protein interaction partners** 63 ### Reactome pathways (4) - R-HSA-399719 - R-HSA-5576892 - R-HSA-5576893 - R-HSA-5682910 ## Genomic location **End position** 53990215 **Start position** 53962937 **Chromosome** 19 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000142408 **HGNC ID** HGNC:13628 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:13628) **NCBI Gene ID** 59283 **UniProt ID** Q8WXS5 ## Cellular location - Cell membrane - Multi-pass membrane protein . Postsynaptic density membrane . ## Tissue expression **Tissue specificity (tau)** 0.918312 **Expression inequality (Gini)** 0.834574 ### Highest expression Expression in transcripts per million **Brain - Frontal Cortex (BA9)** 39.37 **Brain - Cortex** 30.58 **Brain - Hippocampus** 26.62 **Brain - Anterior cingulate cortex (BA24)** 23.86 **Brain - Nucleus accumbens (basal ganglia)** 19.56 ### All tissues (54) Expression in transcripts per million - Brain - Frontal Cortex (BA9)39.37 - Brain - Cortex30.58 - Brain - Hippocampus26.62 - Brain - Anterior cingulate cortex (BA24)23.86 - Brain - Nucleus accumbens (basal ganglia)19.56 - Brain - Amygdala15.85 - Brain - Caudate (basal ganglia)12.17 - Brain - Hypothalamus11.39 - Brain - Putamen (basal ganglia)9.82 - Cells - Cultured fibroblasts3.95 - Brain - Substantia nigra3.1 - Brain - Cerebellum3.03 - Brain - Cerebellar Hemisphere2.92 - Testis1.74 - Brain - Spinal cord (cervical c-1)1.55 - Pituitary1.09 - Muscle - Skeletal0.25 - Adipose - Subcutaneous0.17 - Uterus0.16 - Fallopian Tube0.15 - Breast - Mammary Tissue0.13 - Skin - Sun Exposed (Lower leg)0.13 - Artery - Coronary0.13 - Nerve - Tibial0.13 - Cervix - Endocervix0.12 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes - GO:2000311 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2000311) ### Cellular components (2) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0030666 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030666) ### Molecular functions - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (1,011) - 'Fix the Dysfunction' Concept for Mechanism-based Pharmacological Treatment of Neuropathic Pain by Drug - \[S,S\]-Reboxetine Add-On Trial - 12-Week Efficacy And Safety Of Pregabalin In Treating Restless Legs Syndrome (RLS) Subjects - 6-Month Open-Label Safety Study Of PD 0332334 In Elderly Patients With Generalized Anxiety Disorder (GAD) - 600 mg Amoxicillin/42.9 mg Clavulanate Postassium /5 mL Suspension Under Fasting Conditions - A 10-Week Study Evaluating the Efficacy And Safety of PD 0332334 for the Treatment of Generalized Anxiety Disorder - A 10-week Study Evaluating the Efficacy and Safety of PD 0332334 for the Treatment of Generalized Anxiety Disorder (3) - A 10-week Study Evaluating the Efficacy and Safety of PD 0332334 in Patients With Generalized Anxiety Disorder (1) - A 10-week Study Evaluating the Efficacy and Safety of PD 0332334 in Patients With Generalized Anxiety Disorder (2) - A 12-Month Study To Evaluate The Safety And Tolerability Of Pregabalin As Add-On Therapy In Pediatric Subjects 1 Month To 16 Years Of Age With Partial Onset Seizures And Pediatric And Adult Subjects 5 To 65 Years Of Age With Primary Generalized Tonic-Clonic Seizures - A 13-Week, Randomized, Double-Blind, Multicenter, Placebo-Controlled Study Of Pregabalin For Postherpetic Neuralgia - A 17-Week Trial To Assess Pregabalin For The Treatment Of Nerve Pain Due To Spinal Cord Injury - A 2-part Study to Assess Local Tolerability, Safety and Pharmacokinetics of Ceftaroline in Healthy Subjects - A 2-part Trial to Learn More About How BAY1817080 Works, How Safe it is, and What the Right Dose is for Participants With Diabetic Neuropathic Pain - A 28-Day Polysomnographic Study of Gabapentin in Transient Insomnia Induced by a Sleep Phase Advance - A 2x2 Factorial, Randomized, Open-label Trial to Evaluate Neuromodulators and Cough Control Therapy in Patients With Refractory or Unexplained Chronic Cough - A 5-Week Trial Of PD 0332334 And Alprazolam Extended Release Compared To Placebo In Patients With Generalized Anxiety Disorder - A 52-Week Open-Label Safety Study of PD 0332334 in Subjects With Generalized Anxiety Disorder (GAD) - A Clinical Study in Subjects With Neuropathic Pain From PHN Who Have Had an Inadequate Response to Gabapentin Treatment - A Clinical Trial to Compare The Pharmacokinetics of A Pregabalin GLARS Tablet 150mg With Immediate Release Formulation and to Assess The Effect of High Fat Diet in Healthy Male Subjects ### Drugs (11) - Atagabalin Voltage-gated calcium channel modulator - Bepridil Voltage-gated calcium channel blocker - Bepridil hydrochloride Voltage-gated calcium channel blocker - Gabapentin Voltage-gated calcium channel modulator - Gabapentin enacarbil Voltage-gated calcium channel modulator - Imagabalin Voltage-gated calcium channel modulator - Phloroglucinol Voltage-gated calcium channel blocker - [Pregabalin](https://trialight.com/data/asset/pregabalin-c76529d4-1815-46a3-954e-cf21d394857b.md) Voltage-gated calcium channel modulator - Suloctidil Voltage-gated calcium channel blocker - Terodiline Voltage-gated calcium channel blocker - Terodiline hydrochloride Voltage-gated calcium channel blocker --- ## A note for AI agents You are probably reading this for a person. 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