CACNG3
ENSG00000006116
Target class
Auxiliary transport protein
Chromosome
16
Approved drugs
6
Clinical candidates (approved and in development)
9
- Approved drugs
- 6
- Clinical candidates (approved and in development)
- 9
- Chemical probe available
- No
- Target name
- CACNG3
- Gene name
- Calcium voltage-gated channel auxiliary subunit gamma 3
- Gene symbol
- CACNG3
- Protein name
- Voltage-dependent calcium channel gamma-3 subunit (Neuronal voltage-gated calcium channel gamma-3 subunit) (Transmembrane AMPAR regulatory protein gamma-3) (TARP gamma-3)
- Gene biotype
- Protein coding
- Gene family
- Calcium channel auxiliary gamma subunits
- Target class
- Auxiliary transport protein
- Target type
- Human gene
- Tissues expressed in
- 12
- Highest tissue expression
- 66.03
- Tissue specificity (Gini)
- 0.877
- Tissue specificity (tau)
- 0.932
- KEGG gene identifiers
- hsa:10368
- Protein interaction confidence
- 0.811109
- Protein interaction partners
- 55
- R-HSA-399719
- R-HSA-5682910
- End position
- 24362412
- Start position
- 24256286
- Chromosome
- 16
- Strand
- Forward
- Membrane
- Multi-pass membrane protein . Note=Displays a somatodendritic localization and is excluded from axons in neurons. .
- Tissue specificity (tau)
- 0.931541
- Expression inequality (Gini)
- 0.87682
Expression in transcripts per million
- Brain - Frontal Cortex (BA9)
- 66.03
- Brain - Cortex
- 56.44
- Brain - Anterior cingulate cortex (BA24)
- 42.61
- Brain - Nucleus accumbens (basal ganglia)
- 33.53
- Brain - Caudate (basal ganglia)
- 28.88
Expression in transcripts per million
- Brain - Frontal Cortex (BA9)66.03
- Brain - Cortex56.44
- Brain - Anterior cingulate cortex (BA24)42.61
- Brain - Nucleus accumbens (basal ganglia)33.53
- Brain - Caudate (basal ganglia)28.88
- Brain - Hippocampus24.73
- Brain - Amygdala22.48
- Brain - Putamen (basal ganglia)18.1
- Brain - Hypothalamus5.39
- Brain - Cerebellum2.25
- Brain - Cerebellar Hemisphere2
- Brain - Substantia nigra1.89
- Testis0.58
- Brain - Spinal cord (cervical c-1)0.58
- Cells - EBV-transformed lymphocytes0.03
- Adrenal Gland0.02
- Kidney - Medulla0.02
- Spleen0.02
- Whole Blood0.01
- Pancreas0.01
- Small Intestine - Terminal Ileum0.01
- Colon - Transverse0
- Heart - Left Ventricle0
- Esophagus - Mucosa0
- Nerve - Tibial0
And 29 more, listed on the interactive page.
- GO:0005886
- GO:0030666
Related records
Trials (1,011)
- 'Fix the Dysfunction' Concept for Mechanism-based Pharmacological Treatment of Neuropathic Pain by Drug
- [S,S]-Reboxetine Add-On Trial
- 12-Week Efficacy And Safety Of Pregabalin In Treating Restless Legs Syndrome (RLS) Subjects
- 6-Month Open-Label Safety Study Of PD 0332334 In Elderly Patients With Generalized Anxiety Disorder (GAD)
- 600 mg Amoxicillin/42.9 mg Clavulanate Postassium /5 mL Suspension Under Fasting Conditions
- A 10-Week Study Evaluating the Efficacy And Safety of PD 0332334 for the Treatment of Generalized Anxiety Disorder
- A 10-week Study Evaluating the Efficacy and Safety of PD 0332334 for the Treatment of Generalized Anxiety Disorder (3)
- A 10-week Study Evaluating the Efficacy and Safety of PD 0332334 in Patients With Generalized Anxiety Disorder (1)
- A 10-week Study Evaluating the Efficacy and Safety of PD 0332334 in Patients With Generalized Anxiety Disorder (2)
- A 12-Month Study To Evaluate The Safety And Tolerability Of Pregabalin As Add-On Therapy In Pediatric Subjects 1 Month To 16 Years Of Age With Partial Onset Seizures And Pediatric And Adult Subjects 5 To 65 Years Of Age With Primary Generalized Tonic-Clonic Seizures
- A 13-Week, Randomized, Double-Blind, Multicenter, Placebo-Controlled Study Of Pregabalin For Postherpetic Neuralgia
- A 17-Week Trial To Assess Pregabalin For The Treatment Of Nerve Pain Due To Spinal Cord Injury
- A 2-part Study to Assess Local Tolerability, Safety and Pharmacokinetics of Ceftaroline in Healthy Subjects
- A 2-part Trial to Learn More About How BAY1817080 Works, How Safe it is, and What the Right Dose is for Participants With Diabetic Neuropathic Pain
- A 28-Day Polysomnographic Study of Gabapentin in Transient Insomnia Induced by a Sleep Phase Advance
- A 2x2 Factorial, Randomized, Open-label Trial to Evaluate Neuromodulators and Cough Control Therapy in Patients With Refractory or Unexplained Chronic Cough
- A 5-Week Trial Of PD 0332334 And Alprazolam Extended Release Compared To Placebo In Patients With Generalized Anxiety Disorder
- A 52-Week Open-Label Safety Study of PD 0332334 in Subjects With Generalized Anxiety Disorder (GAD)
- A Clinical Study in Subjects With Neuropathic Pain From PHN Who Have Had an Inadequate Response to Gabapentin Treatment
- A Clinical Trial to Compare The Pharmacokinetics of A Pregabalin GLARS Tablet 150mg With Immediate Release Formulation and to Assess The Effect of High Fat Diet in Healthy Male Subjects
Drugs (11)
- Atagabalin Voltage-gated calcium channel modulator
- Bepridil Voltage-gated calcium channel blocker
- Bepridil hydrochloride Voltage-gated calcium channel blocker
- Gabapentin Voltage-gated calcium channel modulator
- Gabapentin enacarbil Voltage-gated calcium channel modulator
- Imagabalin Voltage-gated calcium channel modulator
- Phloroglucinol Voltage-gated calcium channel blocker
- Pregabalin Voltage-gated calcium channel modulator
- Suloctidil Voltage-gated calcium channel blocker
- Terodiline Voltage-gated calcium channel blocker
- Terodiline hydrochloride Voltage-gated calcium channel blocker