> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/cacnb2-0b297a77-ce96-5d3b-a11b-cbf3d5a7090d > Record changed: 2026-10-13 # CACNB2 ENSG00000165995 Target class Auxiliary transport protein Chromosome 10 Approved drugs 6 Clinical candidates (approved and in development) 9 ## Clinical evidence **Approved drugs** 6 **ClinGen gene-disease validity** Disputed **Clinical candidates (approved and in development)** 9 ## Druggability **Chemical probe available** No ## Names **Target name** CACNB2 **Gene name** Calcium voltage-gated channel auxiliary subunit beta 2 **Gene symbol** CACNB2 **Protein name** Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2) (Lambert-Eaton myasthenic syndrome antigen B) (MYSB) ### Previous gene symbols (2) - MYSB - CACNLB2 ## Classification **Gene biotype** Protein coding **Gene family** Membrane associated guanylate kinases|Calcium voltage-gated channel auxiliary beta subunits **Target class** Auxiliary transport protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 52 **Highest tissue expression** 40.3 **Tissue specificity (Gini)** 0.496 **Tissue specificity (tau)** 0.796 ## Pathways and interactions **KEGG gene identifiers** - hsa:783 **Protein interaction confidence** 0.822566 **Protein interaction partners** 53 ### Reactome pathways (8) - R-HSA-112308 - R-HSA-400042 - R-HSA-419037 - R-HSA-422356 - R-HSA-5576892 - R-HSA-5576893 - R-HSA-9662360 - R-HSA-9856532 ## Genomic location **End position** 18543557 **Start position** 18140424 **Chromosome** 10 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000165995 **HGNC ID** HGNC:1402 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:1402) **NCBI Gene ID** 783 **UniProt ID** Q08289 ## Cellular location - Cell membrane, sarcolemma - Peripheral membrane protein - Cytoplasmic side . ## Tissue expression **Tissue specificity (tau)** 0.795501 **Expression inequality (Gini)** 0.495645 ### Highest expression Expression in transcripts per million **Esophagus - Muscularis** 40.3 **Esophagus - Gastroesophageal Junction** 35.89 **Brain - Cerebellar Hemisphere** 27.65 **Pituitary** 23.96 **Brain - Cerebellum** 23.26 ### All tissues (54) Expression in transcripts per million - Esophagus - Muscularis40.3 - Esophagus - Gastroesophageal Junction35.89 - Brain - Cerebellar Hemisphere27.65 - Pituitary23.96 - Brain - Cerebellum23.26 - Bladder21.17 - Colon - Sigmoid20.19 - Brain - Frontal Cortex (BA9)17.7 - Ovary17.35 - Fallopian Tube13.98 - Brain - Cortex13.64 - Uterus13.53 - Cervix - Ectocervix13.4 - Artery - Tibial12.06 - Cervix - Endocervix11.39 - Brain - Anterior cingulate cortex (BA24)11.05 - Small Intestine - Terminal Ileum9.68 - Brain - Nucleus accumbens (basal ganglia)9.36 - Colon - Transverse9.26 - Prostate9.22 - Heart - Atrial Appendage8.75 - Brain - Hypothalamus7.8 - Heart - Left Ventricle7.72 - Artery - Coronary7.7 - Artery - Aorta6.98 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (6) - GO:0007528 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007528) - GO:0051928 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051928) - GO:0070509 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070509) - GO:0086045 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0086045) - GO:0086091 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0086091) - GO:0098912 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0098912) ### Cellular components (3) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0005891 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005891) - GO:1990454 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1990454) ### Molecular functions (5) - GO:0005245 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005245) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0008331 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008331) - GO:0086007 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0086007) - GO:0086056 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0086056) ## Related records ### Trials (1,011) - 'Fix the Dysfunction' Concept for Mechanism-based Pharmacological Treatment of Neuropathic Pain by Drug - \[S,S\]-Reboxetine Add-On Trial - 12-Week Efficacy And Safety Of Pregabalin In Treating Restless Legs Syndrome (RLS) Subjects - 6-Month Open-Label Safety Study Of PD 0332334 In Elderly Patients With Generalized Anxiety Disorder (GAD) - 600 mg Amoxicillin/42.9 mg Clavulanate Postassium /5 mL Suspension Under Fasting Conditions - A 10-Week Study Evaluating the Efficacy And Safety of PD 0332334 for the Treatment of Generalized Anxiety Disorder - A 10-week Study Evaluating the Efficacy and Safety of PD 0332334 for the Treatment of Generalized Anxiety Disorder (3) - A 10-week Study Evaluating the Efficacy and Safety of PD 0332334 in Patients With Generalized Anxiety Disorder (1) - A 10-week Study Evaluating the Efficacy and Safety of PD 0332334 in Patients With Generalized Anxiety Disorder (2) - A 12-Month Study To Evaluate The Safety And Tolerability Of Pregabalin As Add-On Therapy In Pediatric Subjects 1 Month To 16 Years Of Age With Partial Onset Seizures And Pediatric And Adult Subjects 5 To 65 Years Of Age With Primary Generalized Tonic-Clonic Seizures - A 13-Week, Randomized, Double-Blind, Multicenter, Placebo-Controlled Study Of Pregabalin For Postherpetic Neuralgia - A 17-Week Trial To Assess Pregabalin For The Treatment Of Nerve Pain Due To Spinal Cord Injury - A 2-part Study to Assess Local Tolerability, Safety and Pharmacokinetics of Ceftaroline in Healthy Subjects - A 2-part Trial to Learn More About How BAY1817080 Works, How Safe it is, and What the Right Dose is for Participants With Diabetic Neuropathic Pain - A 28-Day Polysomnographic Study of Gabapentin in Transient Insomnia Induced by a Sleep Phase Advance - A 2x2 Factorial, Randomized, Open-label Trial to Evaluate Neuromodulators and Cough Control Therapy in Patients With Refractory or Unexplained Chronic Cough - A 5-Week Trial Of PD 0332334 And Alprazolam Extended Release Compared To Placebo In Patients With Generalized Anxiety Disorder - A 52-Week Open-Label Safety Study of PD 0332334 in Subjects With Generalized Anxiety Disorder (GAD) - A Clinical Study in Subjects With Neuropathic Pain From PHN Who Have Had an Inadequate Response to Gabapentin Treatment - A Clinical Trial to Compare The Pharmacokinetics of A Pregabalin GLARS Tablet 150mg With Immediate Release Formulation and to Assess The Effect of High Fat Diet in Healthy Male Subjects ### Drugs (11) - Atagabalin Voltage-gated calcium channel modulator - Bepridil Voltage-gated calcium channel blocker - Bepridil hydrochloride Voltage-gated calcium channel blocker - Gabapentin Voltage-gated calcium channel modulator - Gabapentin enacarbil Voltage-gated calcium channel modulator - Imagabalin Voltage-gated calcium channel modulator - Phloroglucinol Voltage-gated calcium channel blocker - [Pregabalin](https://trialight.com/data/asset/pregabalin-c76529d4-1815-46a3-954e-cf21d394857b.md) Voltage-gated calcium channel modulator - Suloctidil Voltage-gated calcium channel blocker - Terodiline Voltage-gated calcium channel blocker - Terodiline hydrochloride Voltage-gated calcium channel blocker --- ## A note for AI agents You are probably reading this for a person. 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