> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/cacna1s-323f267a-8656-5845-a35c-8ccdc4d6896d > Record changed: 2026-10-13 # CACNA1S ENSG00000081248 Target class Ion channel Chromosome 1 Approved drugs 21 Clinical candidates (approved and in development) 35 ## Clinical evidence **Approved drugs** 21 **ClinGen gene-disease validity** Moderate **Clinical candidates (approved and in development)** 35 ## Druggability **Chemical probe available** No ## Names **Target name** CACNA1S **Gene name** Calcium voltage-gated channel subunit alpha1 S **Gene symbol** CACNA1S **Protein name** Voltage-dependent L-type calcium channel subunit alpha-1S (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle) (Voltage-gated calcium channel subunit alpha Cav1.1) ### Other names (2) - Cav1.1 - hypoPP ### Previous gene symbols (3) - HOKPP - MHS5 - CACNL1A3 ## Classification **Gene biotype** Protein coding **Gene family** Calcium voltage-gated channel alpha1 subunits **Target class** Ion channel **Target type** Human gene ## Expression and localisation **Tissues expressed in** 1 **Protein localisation evidence grade** Approved **Highest tissue expression** 108.33 **Tissue specificity (Gini)** 0.961 **Tissue specificity (tau)** 0.999 ## Pathways and interactions **KEGG gene identifiers** - hsa:779 **Reactome pathways** - R-HSA-419037 **Protein interaction confidence** 0.857176 **Protein interaction partners** 74 ## Genomic location **End position** 201112451 **Start position** 201039512 **Chromosome** 1 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000081248 **HGNC ID** HGNC:1397 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:1397) **NCBI Gene ID** 779 **UniProt ID** Q13698 ## Cellular location - Cell membrane, sarcolemma, T-tubule - Multi-pass membrane protein . - Acrosome - Equatorial segment ### Publication evidence - PubMed 28012042 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28012042/) ## Tissue expression **Tissue specificity (tau)** 0.999103 **Expression inequality (Gini)** 0.961471 ### Highest expression Expression in transcripts per million **Muscle - Skeletal** 108.33 **Brain - Nucleus accumbens (basal ganglia)** 0.51 **Artery - Tibial** 0.4 **Brain - Caudate (basal ganglia)** 0.37 **Testis** 0.36 ### All tissues (54) Expression in transcripts per million - Muscle - Skeletal108.33 - Brain - Nucleus accumbens (basal ganglia)0.51 - Artery - Tibial0.4 - Brain - Caudate (basal ganglia)0.37 - Testis0.36 - Brain - Cortex0.33 - Brain - Frontal Cortex (BA9)0.28 - Brain - Hypothalamus0.27 - Brain - Putamen (basal ganglia)0.25 - Brain - Substantia nigra0.24 - Lung0.18 - Artery - Coronary0.15 - Brain - Anterior cingulate cortex (BA24)0.14 - Minor Salivary Gland0.14 - Kidney - Cortex0.11 - Brain - Amygdala0.09 - Skin - Sun Exposed (Lower leg)0.07 - Adipose - Visceral (Omentum)0.07 - Brain - Hippocampus0.07 - Heart - Atrial Appendage0.06 - Nerve - Tibial0.06 - Bladder0.05 - Colon - Transverse0.05 - Small Intestine - Terminal Ileum0.05 - Kidney - Medulla0.05 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (3) - GO:0006816 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006816) - GO:0006936 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006936) - GO:0051209 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051209) ### Cellular components (5) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0005891 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005891) - GO:0030315 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030315) - GO:0031674 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031674) ### Molecular functions (5) - GO:0005245 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005245) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0008331 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008331) - GO:0036094 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0036094) - GO:0140677 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140677) ## Related records ### Trials (2,059) - 'Fix the Dysfunction' Concept for Mechanism-based Pharmacological Treatment of Neuropathic Pain by Drug - \[S,S\]-Reboxetine Add-On Trial - 12-Week Efficacy And Safety Of Pregabalin In Treating Restless Legs Syndrome (RLS) Subjects - 18 Week Study Evaluating Safety and Efficacy of Olmesartan, Amlodipine, and Hydrochlorothiazide, in Type 2 Diabetics - 26-week Open Study of telmisartan40mg+amlodipine10mg or telmisartan80mg+amlodipine10 mg in Hypertension - 6-Month Open-Label Safety Study Of PD 0332334 In Elderly Patients With Generalized Anxiety Disorder (GAD) - 600 mg Amoxicillin/42.9 mg Clavulanate Postassium /5 mL Suspension Under Fasting Conditions - 8-week Study to Evaluate Safety and Efficacy of Various Combinations of Valsartan, HCTZ, and Amlodipine in Patients With Moderate to Severe Hypertension - A 10-Week Study Evaluating the Efficacy And Safety of PD 0332334 for the Treatment of Generalized Anxiety Disorder - A 10-week Study Evaluating the Efficacy and Safety of PD 0332334 for the Treatment of Generalized Anxiety Disorder (3) - A 10-week Study Evaluating the Efficacy and Safety of PD 0332334 in Patients With Generalized Anxiety Disorder (1) - A 10-week Study Evaluating the Efficacy and Safety of PD 0332334 in Patients With Generalized Anxiety Disorder (2) - A 12-Month Study To Evaluate The Safety And Tolerability Of Pregabalin As Add-On Therapy In Pediatric Subjects 1 Month To 16 Years Of Age With Partial Onset Seizures And Pediatric And Adult Subjects 5 To 65 Years Of Age With Primary Generalized Tonic-Clonic Seizures - A 13-Week, Randomized, Double-Blind, Multicenter, Placebo-Controlled Study Of Pregabalin For Postherpetic Neuralgia - A 17-Week Trial To Assess Pregabalin For The Treatment Of Nerve Pain Due To Spinal Cord Injury - A 2-part Study to Assess Local Tolerability, Safety and Pharmacokinetics of Ceftaroline in Healthy Subjects - A 2-part Trial to Learn More About How BAY1817080 Works, How Safe it is, and What the Right Dose is for Participants With Diabetic Neuropathic Pain - A 21-Day Topical Safety Study of Diltiazem Hydrochloride Using a Cumulative Irritant Patch Test Design - A 28-Day Polysomnographic Study of Gabapentin in Transient Insomnia Induced by a Sleep Phase Advance - A 2x2 Factorial, Randomized, Open-label Trial to Evaluate Neuromodulators and Cough Control Therapy in Patients With Refractory or Unexplained Chronic Cough ### Drugs (44) - [Amlodipine](https://trialight.com/data/asset/amlodipine-b06f8f1a-f55d-4a6b-b513-c6443387d4ae.md) Voltage-gated L-type calcium channel blocker - Amlodipine benzoate Voltage-gated L-type calcium channel blocker - Amlodipine besylate Voltage-gated L-type calcium channel blocker - Amlodipine maleate Voltage-gated L-type calcium channel blocker - Atagabalin Voltage-gated calcium channel modulator - AZD1305 Voltage-gated L-type calcium channel blocker - Azelnidipine Voltage-gated L-type calcium channel blocker - Barnidipine Voltage-gated L-type calcium channel blocker - Benidipine Voltage-gated L-type calcium channel blocker - Bepridil Voltage-gated calcium channel blocker - Bepridil hydrochloride Voltage-gated calcium channel blocker - Cilnidipine Voltage-gated L-type calcium channel blocker - Cinnarizine Voltage-gated L-type calcium channel blocker - Clevidipine Voltage-gated L-type calcium channel blocker - Diltiazem Voltage-gated L-type calcium channel blocker - Diltiazem hydrochloride Voltage-gated L-type calcium channel blocker - Diltiazem malate Voltage-gated L-type calcium channel blocker - Dronedarone Voltage-gated L-type calcium channel blocker - Dronedarone hydrochloride Voltage-gated L-type calcium channel blocker - Elpetrigine Voltage-gated L-type calcium channel blocker --- ## A note for AI agents You are probably reading this for a person. 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