> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/cacna1h-595ec1a8-0caa-50c4-aeb4-988ee9ca4795 > Record changed: 2026-10-13 # CACNA1H ENSG00000196557 Target class Ion channel Chromosome 16 Approved drugs 12 Clinical candidates (approved and in development) 18 ## Clinical evidence **Approved drugs** 12 **Clinical candidates (approved and in development)** 18 ## Druggability **Chemical probe available** Yes ## Names **Other names** - Cav3.2 **Target name** CACNA1H **Gene name** Calcium voltage-gated channel subunit alpha1 H **Gene symbol** CACNA1H **Protein name** Voltage-dependent T-type calcium channel subunit alpha-1H (Low-voltage-activated calcium channel alpha1 3.2 subunit) (Voltage-gated calcium channel subunit alpha Cav3.2) ## Classification **Gene biotype** Protein coding **Gene family** Calcium voltage-gated channel alpha1 subunits **Target class** Ion channel **Target type** Human gene ## Expression and localisation **Tissues expressed in** 50 **Protein localisation evidence grade** Approved **Highest tissue expression** 212.68 **Tissue specificity (Gini)** 0.641 **Tissue specificity (tau)** 0.832 ## Pathways and interactions **KEGG gene identifiers** - hsa:8912 **Protein interaction confidence** 0.81725 **Protein interaction partners** 68 ### Reactome pathways (3) - R-HSA-419037 - R-HSA-445355 - R-HSA-9856532 ## Genomic location **End position** 1224169 **Start position** 1153103 **Chromosome** 16 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000196557 **HGNC ID** HGNC:1395 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:1395) **NCBI Gene ID** 8912 **UniProt ID** O95180 ## Cellular location - Cell membrane - Multi-pass membrane protein . Note=Interaction with STAC increases expression at the cell membrane. . - Nucleoplasm - Vesicles ### Publication evidence (5) - PubMed 25907736 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/25907736/) - PubMed 27149520 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/27149520/) - PubMed 27729216 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/27729216/) - PubMed 9670923 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/9670923/) - PubMed 9930755 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/9930755/) ## Tissue expression **Tissue specificity (tau)** 0.832165 **Expression inequality (Gini)** 0.641014 ### Highest expression Expression in transcripts per million **Colon - Sigmoid** 212.68 **Esophagus - Muscularis** 190.76 **Ovary** 175.42 **Esophagus - Gastroesophageal Junction** 158.57 **Uterus** 130.32 ### All tissues (54) Expression in transcripts per million - Colon - Sigmoid212.68 - Esophagus - Muscularis190.76 - Ovary175.42 - Esophagus - Gastroesophageal Junction158.57 - Uterus130.32 - Bladder128.92 - Artery - Tibial114.56 - Pituitary107.39 - Fallopian Tube86.6 - Cervix - Endocervix71.11 - Cervix - Ectocervix66.45 - Artery - Coronary65.95 - Prostate60.12 - Colon - Transverse57.58 - Testis48.03 - Adrenal Gland30.4 - Skin - Sun Exposed (Lower leg)29.18 - Vagina27.47 - Thyroid25.02 - Lung24.49 - Adipose - Subcutaneous22.84 - Kidney - Medulla20.41 - Brain - Nucleus accumbens (basal ganglia)18.95 - Brain - Caudate (basal ganglia)18.77 - Brain - Putamen (basal ganglia)16.63 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (11) - GO:0006936 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006936) - GO:0007520 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007520) - GO:0008016 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008016) - GO:0032342 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032342) - GO:0032870 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032870) - GO:0034651 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034651) - GO:0035865 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035865) - GO:0042391 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042391) - GO:0055085 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0055085) - GO:0070509 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070509) - GO:2000344 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2000344) ### Cellular components (3) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0005891 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005891) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) ### Molecular functions (5) - GO:0005244 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005244) - GO:0005245 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005245) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0008332 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008332) - GO:0097110 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097110) ## Related records ### Trials (1,036) - 'Fix the Dysfunction' Concept for Mechanism-based Pharmacological Treatment of Neuropathic Pain by Drug - \[S,S\]-Reboxetine Add-On Trial - 12-Week Efficacy And Safety Of Pregabalin In Treating Restless Legs Syndrome (RLS) Subjects - 6-Month Open-Label Safety Study Of PD 0332334 In Elderly Patients With Generalized Anxiety Disorder (GAD) - 600 mg Amoxicillin/42.9 mg Clavulanate Postassium /5 mL Suspension Under Fasting Conditions - A 10-Week Study Evaluating the Efficacy And Safety of PD 0332334 for the Treatment of Generalized Anxiety Disorder - A 10-week Study Evaluating the Efficacy and Safety of PD 0332334 for the Treatment of Generalized Anxiety Disorder (3) - A 10-week Study Evaluating the Efficacy and Safety of PD 0332334 in Patients With Generalized Anxiety Disorder (1) - A 10-week Study Evaluating the Efficacy and Safety of PD 0332334 in Patients With Generalized Anxiety Disorder (2) - A 12-Month Study To Evaluate The Safety And Tolerability Of Pregabalin As Add-On Therapy In Pediatric Subjects 1 Month To 16 Years Of Age With Partial Onset Seizures And Pediatric And Adult Subjects 5 To 65 Years Of Age With Primary Generalized Tonic-Clonic Seizures - A 13-Week, Randomized, Double-Blind, Multicenter, Placebo-Controlled Study Of Pregabalin For Postherpetic Neuralgia - A 17-Week Trial To Assess Pregabalin For The Treatment Of Nerve Pain Due To Spinal Cord Injury - A 2-part Study to Assess Local Tolerability, Safety and Pharmacokinetics of Ceftaroline in Healthy Subjects - A 2-part Trial to Learn More About How BAY1817080 Works, How Safe it is, and What the Right Dose is for Participants With Diabetic Neuropathic Pain - A 28-Day Polysomnographic Study of Gabapentin in Transient Insomnia Induced by a Sleep Phase Advance - A 2x2 Factorial, Randomized, Open-label Trial to Evaluate Neuromodulators and Cough Control Therapy in Patients With Refractory or Unexplained Chronic Cough - A 5-Week Trial Of PD 0332334 And Alprazolam Extended Release Compared To Placebo In Patients With Generalized Anxiety Disorder - A 52-Week Open-Label Safety Study of PD 0332334 in Subjects With Generalized Anxiety Disorder (GAD) - A Clinical Study in Subjects With Neuropathic Pain From PHN Who Have Had an Inadequate Response to Gabapentin Treatment - A Clinical Trial to Compare The Pharmacokinetics of A Pregabalin GLARS Tablet 150mg With Immediate Release Formulation and to Assess The Effect of High Fat Diet in Healthy Male Subjects ### Drugs (21) - ABT-639 Voltage-gated T-type calcium channel alpha-1H subunit blocker - Apinocaltamide Voltage-gated T-type calcium channel blocker - Atagabalin Voltage-gated calcium channel modulator - Bepridil Voltage-gated calcium channel blocker - Bepridil hydrochloride Voltage-gated calcium channel blocker - Ethosuximide Voltage-gated T-type calcium channel blocker - Gabapentin Voltage-gated calcium channel modulator - Gabapentin enacarbil Voltage-gated calcium channel modulator - Imagabalin Voltage-gated calcium channel modulator - Methsuximide Voltage-gated T-type calcium channel blocker - Mibefradil Voltage-gated T-type calcium channel blocker - Mibefradil dihydrochloride Voltage-gated T-type calcium channel blocker - Paramethadione Voltage-gated T-type calcium channel blocker - Phensuximide Voltage-gated T-type calcium channel blocker - Phloroglucinol Voltage-gated calcium channel blocker - [Pregabalin](https://trialight.com/data/asset/pregabalin-c76529d4-1815-46a3-954e-cf21d394857b.md) Voltage-gated calcium channel modulator - Suloctidil Voltage-gated calcium channel blocker - [Suvecaltamide](https://trialight.com/data/asset/suvecaltamide-1f532561-72d0-4641-a916-d39d5b361df4.md) Voltage-gated T-type calcium channel modulator - Terodiline Voltage-gated calcium channel blocker - Terodiline hydrochloride Voltage-gated calcium channel blocker --- ## A note for AI agents You are probably reading this for a person. 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