> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/cacna1c-744d59ab-a8de-5b82-a952-b270470e3b23 > Record changed: 2026-10-13 # CACNA1C ENSG00000151067 Target class Ion channel Chromosome 12 Approved drugs 21 Clinical candidates (approved and in development) 35 ## Clinical evidence **Approved drugs** 21 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 35 ## Druggability **Chemical probe available** No ## Names **Target name** CACNA1C **Gene name** Calcium voltage-gated channel subunit alpha1 C **Gene symbol** CACNA1C **Protein name** Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Voltage-gated calcium channel subunit alpha Cav1.2) ### Other names (5) - Cav1.2 - CACH2 - CACN2 - TS - LQT8 ### Previous gene symbols (3) - CCHL1A1 - CACNL1A1 - CACNA1C-IT2 ## Classification **Gene biotype** Protein coding **Gene family** Calcium voltage-gated channel alpha1 subunits **Target class** Ion channel **Target type** Human gene ## Expression and localisation **Tissues expressed in** 48 **Protein localisation evidence grade** Approved **Highest tissue expression** 44.45 **Tissue specificity (Gini)** 0.575 **Tissue specificity (tau)** 0.852 ## Pathways and interactions **KEGG gene identifiers** - hsa:775 **Protein interaction confidence** 0.850958 **Protein interaction partners** 119 ### Reactome pathways (5) - R-HSA-400042 - R-HSA-419037 - R-HSA-422356 - R-HSA-5576892 - R-HSA-5576893 ## Genomic location **End position** 2697950 **Start position** 1970772 **Chromosome** 12 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000151067 **HGNC ID** HGNC:1390 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:1390) **NCBI Gene ID** 775 **UniProt ID** Q13936 ## Cellular location - Cell membrane - Multi-pass membrane protein . Cell membrane, sarcolemma - Multi-pass membrane protein . Perikaryon . Postsynaptic density membrane . Cell projection, dendrite . Cell membrane, sarcolemma, T-tubule . Note=Colocalizes with ryanodine receptors in distinct clusters at the junctional membrane, where the sarcolemma and the sarcoplasmic reticulum are in close contact. The interaction between RRAD and CACNB2 promotes the expression of CACNA1C at the cell membrane. . - Plasma membrane ### Publication evidence (20) - PubMed 11741969 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/11741969/) - PubMed 12176756 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/12176756/) - PubMed 12181424 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/12181424/) - PubMed 15454078 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/15454078/) - PubMed 15863612 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/15863612/) - PubMed 16299511 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/16299511/) - PubMed 17071743 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/17071743/) - PubMed 17224476 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/17224476/) - PubMed 20953164 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/20953164/) - PubMed 24728418 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/24728418/) - PubMed 26253506 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/26253506/) - PubMed 27218670 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/27218670/) - PubMed 29078335 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/29078335/) - PubMed 29742403 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/29742403/) - PubMed 7737988 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/7737988/) - PubMed 8099908 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/8099908/) - PubMed 8392192 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/8392192/) - PubMed 9013606 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/9013606/) - PubMed 9087614 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/9087614/) - PubMed 9607315 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/9607315/) ## Tissue expression **Tissue specificity (tau)** 0.851667 **Expression inequality (Gini)** 0.575064 ### Highest expression Expression in transcripts per million **Colon - Sigmoid** 44.45 **Uterus** 33.64 **Artery - Coronary** 26.33 **Esophagus - Muscularis** 24.9 **Artery - Tibial** 23.21 ### All tissues (54) Expression in transcripts per million - Colon - Sigmoid44.45 - Uterus33.64 - Artery - Coronary26.33 - Esophagus - Muscularis24.9 - Artery - Tibial23.21 - Artery - Aorta23.03 - Esophagus - Gastroesophageal Junction19.16 - Bladder16.56 - Heart - Atrial Appendage11.04 - Colon - Transverse10.83 - Heart - Left Ventricle10.65 - Cervix - Endocervix10.57 - Prostate9.5 - Cervix - Ectocervix8.32 - Pituitary8.29 - Brain - Cerebellum7.97 - Lung7.06 - Brain - Cerebellar Hemisphere6.98 - Fallopian Tube6.48 - Brain - Cortex6.15 - Cells - Cultured fibroblasts5.71 - Brain - Frontal Cortex (BA9)5.61 - Vagina4.69 - Testis4.62 - Spleen4.35 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (17) - GO:0002520 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002520) - GO:0007204 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007204) - GO:0007507 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007507) - GO:0010881 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010881) - GO:0035115 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035115) - GO:0043010 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043010) - GO:0060402 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060402) - GO:0061337 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0061337) - GO:0061577 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0061577) - GO:0070588 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070588) - GO:0086002 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0086002) - GO:0086012 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0086012) - GO:0086045 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0086045) - GO:0086064 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0086064) - GO:0086091 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0086091) - GO:0098911 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0098911) - GO:0098912 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0098912) ### Cellular components (6) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0005891 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005891) - GO:0014069 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0014069) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) - GO:1990454 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1990454) ### Molecular functions (7) - GO:0005245 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005245) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0005516 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005516) - GO:0008331 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008331) - GO:0051393 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051393) - GO:0086007 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0086007) - GO:0086056 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0086056) ## On-target safety - increased mortality of heart failure patients ### Effects - Activation/Increase/Upregulation: general ### Studies - clinical: increased mortality of heart failure patients ### Biological samples (3) - cardiovascular system - nervous system - gastrointestinal Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - fluid buildup in the legs ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - clinical: fluid buildup in the legs ### Biological samples (3) - cardiovascular system - nervous system - gastrointestinal Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - dizziness ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - clinical: dizziness ### Biological samples (3) - cardiovascular system - nervous system - gastrointestinal Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - increased convulsions ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: increased convulsions ### Biological samples (2) - central nervous system - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - induction of seizures ### Effects - Activation/Increase/Upregulation: general ### Studies - clinical: induction of seizures ### Biological samples (3) - cardiovascular system - nervous system - gastrointestinal Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - decreased/increased convulsions ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: decreased/increased convulsions ### Biological samples (2) - central nervous system - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - increased PR interval ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: increased PR interval ### Biological samples (2) - central nervous system - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - effect on heart rate ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - clinical: effect on heart rate ### Biological samples (3) - cardiovascular system - nervous system - gastrointestinal Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - hypotension ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - clinical: hypotension ### Biological samples (3) - cardiovascular system - nervous system - gastrointestinal Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - reflex tachycardia ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - clinical: reflex tachycardia ### Biological samples (3) - cardiovascular system - nervous system - gastrointestinal Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - decreased cardiac contractility ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: decreased cardiac contractility ### Biological samples (2) - central nervous system - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - decreased locomotor activity ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: decreased locomotor activity ### Biological samples (2) - central nervous system - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - constipation ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - clinical: constipation ### Biological samples (3) - cardiovascular system - nervous system - gastrointestinal Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - decreased blood pressure ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: decreased blood pressure ### Biological samples (2) - central nervous system - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - increased cardiac contractility ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: increased cardiac contractility ### Biological samples (2) - central nervous system - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - increased systolic blood pressure ### Effects - Activation/Increase/Upregulation: general ### Studies - clinical: increased systolic blood pressure ### Biological samples (3) - cardiovascular system - nervous system - gastrointestinal Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - increases in peripheral vascular resistance ### Effects - Activation/Increase/Upregulation: general ### Studies - clinical: increases in peripheral vascular resistance ### Biological samples (3) - cardiovascular system - nervous system - gastrointestinal Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - increased blood pressure ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: increased blood pressure ### Biological samples (2) - central nervous system - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - arrhythmia ### Effects (2) - Inhibition/Decrease/Downregulation: general - Activation/Increase/Upregulation: general ### Studies - clinical: arrhythmia ### Biological samples (3) - cardiovascular system - nervous system - gastrointestinal Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - headache ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - clinical: headache ### Biological samples (3) - cardiovascular system - nervous system - gastrointestinal Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) - redness in the face ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - clinical: redness in the face ### Biological samples (3) - cardiovascular system - nervous system - gastrointestinal Evidence source Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2) ## Off-target safety - decreased blood pressure ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - preclinical: decreased blood pressure ### Biological samples - cardiovascular system PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - decreased PR interval ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - preclinical: decreased PR interval ### Biological samples - cardiovascular system PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - possible shortening of QT interval of ECG ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - preclinical: possible shortening of QT interval of ECG ### Biological samples - cardiovascular system PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - vascular relaxation ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - preclinical: vascular relaxation ### Biological samples - cardiovascular system PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) ## Related records ### Trials (2,059) - 'Fix the Dysfunction' Concept for Mechanism-based Pharmacological Treatment of Neuropathic Pain by Drug - \[S,S\]-Reboxetine Add-On Trial - 12-Week Efficacy And Safety Of Pregabalin In Treating Restless Legs Syndrome (RLS) Subjects - 18 Week Study Evaluating Safety and Efficacy of Olmesartan, Amlodipine, and Hydrochlorothiazide, in Type 2 Diabetics - 26-week Open Study of telmisartan40mg+amlodipine10mg or telmisartan80mg+amlodipine10 mg in Hypertension - 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A 13-Week, Randomized, Double-Blind, Multicenter, Placebo-Controlled Study Of Pregabalin For Postherpetic Neuralgia - A 17-Week Trial To Assess Pregabalin For The Treatment Of Nerve Pain Due To Spinal Cord Injury - A 2-part Study to Assess Local Tolerability, Safety and Pharmacokinetics of Ceftaroline in Healthy Subjects - A 2-part Trial to Learn More About How BAY1817080 Works, How Safe it is, and What the Right Dose is for Participants With Diabetic Neuropathic Pain - A 21-Day Topical Safety Study of Diltiazem Hydrochloride Using a Cumulative Irritant Patch Test Design - A 28-Day Polysomnographic Study of Gabapentin in Transient Insomnia Induced by a Sleep Phase Advance - A 2x2 Factorial, Randomized, Open-label Trial to Evaluate Neuromodulators and Cough Control Therapy in Patients With Refractory or Unexplained Chronic Cough ### Drugs (44) - [Amlodipine](https://trialight.com/data/asset/amlodipine-b06f8f1a-f55d-4a6b-b513-c6443387d4ae.md) Voltage-gated L-type calcium channel blocker - Amlodipine benzoate Voltage-gated L-type calcium channel blocker - Amlodipine besylate Voltage-gated L-type calcium channel blocker - Amlodipine maleate Voltage-gated L-type calcium channel blocker - Atagabalin Voltage-gated calcium channel modulator - AZD1305 Voltage-gated L-type calcium channel blocker - Azelnidipine Voltage-gated L-type calcium channel blocker - Barnidipine Voltage-gated L-type calcium channel blocker - Benidipine Voltage-gated L-type calcium channel blocker - Bepridil Voltage-gated calcium channel blocker - Bepridil hydrochloride Voltage-gated calcium channel blocker - Cilnidipine Voltage-gated L-type calcium channel blocker - Cinnarizine Voltage-gated L-type calcium channel blocker - Clevidipine Voltage-gated L-type calcium channel blocker - Diltiazem Voltage-gated L-type calcium channel blocker - Diltiazem hydrochloride Voltage-gated L-type calcium channel blocker - Diltiazem malate Voltage-gated L-type calcium channel blocker - Dronedarone Voltage-gated L-type calcium channel blocker - Dronedarone hydrochloride Voltage-gated L-type calcium channel blocker - Elpetrigine Voltage-gated L-type calcium channel blocker --- ## A note for AI agents You are probably reading this for a person. 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