> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/cacna1b-24763181-bb0a-5937-9a02-22235ff3bb78 > Record changed: 2026-10-13 # CACNA1B ENSG00000148408 Target class Ion channel Chromosome 9 Approved drugs 9 Clinical candidates (approved and in development) 16 ## Clinical evidence **Approved drugs** 9 **ClinGen gene-disease validity** Moderate **Clinical candidates (approved and in development)** 16 ## Druggability **Chemical probe available** No ## Names **Target name** CACNA1B **Gene name** Calcium voltage-gated channel subunit alpha1 B **Gene symbol** CACNA1B **Previous gene symbols** - CACNL1A5 **Protein name** Voltage-dependent N-type calcium channel subunit alpha-1B (Brain calcium channel III) (BIII) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Voltage-gated calcium channel subunit alpha Cav2.2) ### Other names (2) - Cav2.2 - CACNN ## Classification **Gene biotype** Protein coding **Gene family** EF-hand domain containing|Calcium voltage-gated channel alpha1 subunits **Target class** Ion channel **Target type** Human gene ## Expression and localisation **Tissues expressed in** 15 **Protein localisation evidence grade** Approved **Highest tissue expression** 51.5 **Tissue specificity (Gini)** 0.822 **Tissue specificity (tau)** 0.932 ## Pathways and interactions **KEGG gene identifiers** - hsa:774 **Reactome pathways** - R-HSA-112308 **Protein interaction confidence** 0.828378 **Protein interaction partners** 45 ## Genomic location **End position** 138124624 **Start position** 137877782 **Chromosome** 9 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000148408 **HGNC ID** HGNC:1389 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:1389) **NCBI Gene ID** 774 **UniProt ID** Q00975 ## Cellular location - Membrane - Multi-pass membrane protein . - Acrosome - Cytosol - Equatorial segment ### Publication evidence - PubMed 34234349 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/34234349/) ## Tissue expression **Tissue specificity (tau)** 0.932021 **Expression inequality (Gini)** 0.821837 ### Highest expression Expression in transcripts per million **Brain - Cerebellum** 51.5 **Brain - Cerebellar Hemisphere** 45.97 **Brain - Cortex** 19.5 **Brain - Frontal Cortex (BA9)** 17.14 **Pituitary** 15.54 ### All tissues (54) Expression in transcripts per million - Brain - Cerebellum51.5 - Brain - Cerebellar Hemisphere45.97 - Brain - Cortex19.5 - Brain - Frontal Cortex (BA9)17.14 - Pituitary15.54 - Brain - Nucleus accumbens (basal ganglia)12.2 - Testis11.99 - Brain - Anterior cingulate cortex (BA24)10.55 - Brain - Hypothalamus9.89 - Brain - Caudate (basal ganglia)9.48 - Brain - Putamen (basal ganglia)7.74 - Brain - Spinal cord (cervical c-1)6.6 - Brain - Amygdala5.33 - Brain - Hippocampus5.08 - Brain - Substantia nigra2.7 - Colon - Sigmoid0.88 - Prostate0.71 - Thyroid0.49 - Fallopian Tube0.44 - Colon - Transverse0.36 - Stomach0.32 - Cervix - Endocervix0.22 - Esophagus - Muscularis0.21 - Vagina0.2 - Esophagus - Gastroesophageal Junction0.17 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (3) - GO:0007268 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007268) - GO:0050804 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050804) - GO:1904645 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1904645) ### Cellular components (3) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0005891 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005891) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) ### Molecular functions (4) - GO:0001540 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001540) - GO:0005245 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005245) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0008331 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008331) ## Related records ### Trials (1,273) - 'Fix the Dysfunction' Concept for Mechanism-based Pharmacological Treatment of Neuropathic Pain by Drug - \[S,S\]-Reboxetine Add-On Trial - 1 Week Versus 6 Weeks of Levetiracetam in Surgical Brain Tumor Patients - 12-Week Efficacy And Safety Of Pregabalin In Treating Restless Legs Syndrome (RLS) Subjects - 6-Month Open-Label Safety Study Of PD 0332334 In Elderly Patients With Generalized Anxiety Disorder (GAD) - 600 mg Amoxicillin/42.9 mg Clavulanate Postassium /5 mL Suspension Under Fasting Conditions - A 10-Week Study Evaluating the Efficacy And Safety of PD 0332334 for the Treatment of Generalized Anxiety Disorder - A 10-week Study Evaluating the Efficacy and Safety of PD 0332334 for the Treatment of Generalized Anxiety Disorder (3) - A 10-week Study Evaluating the Efficacy and Safety of PD 0332334 in Patients With Generalized Anxiety Disorder (1) - A 10-week Study Evaluating the Efficacy and Safety of PD 0332334 in Patients With Generalized Anxiety Disorder (2) - A 12-Month Study To Evaluate The Safety And Tolerability Of Pregabalin As Add-On Therapy In Pediatric Subjects 1 Month To 16 Years Of Age With Partial Onset Seizures And Pediatric And Adult Subjects 5 To 65 Years Of Age With Primary Generalized Tonic-Clonic Seizures - A 13-Week, Randomized, Double-Blind, Multicenter, Placebo-Controlled Study Of Pregabalin For Postherpetic Neuralgia - A 16 Week Study Evaluating Levetiracetam in the Treatment of Post Herpetic Neuralgia (PHN) - A 17-Week Trial To Assess Pregabalin For The Treatment Of Nerve Pain Due To Spinal Cord Injury - A 19-week Cognition Study of Levetiracetam in Children With Partial Onset Seizures - A 2-part Study to Assess Local Tolerability, Safety and Pharmacokinetics of Ceftaroline in Healthy Subjects - A 2-part Trial to Learn More About How BAY1817080 Works, How Safe it is, and What the Right Dose is for Participants With Diabetic Neuropathic Pain - A 28-Day Polysomnographic Study of Gabapentin in Transient Insomnia Induced by a Sleep Phase Advance - A 2x2 Factorial, Randomized, Open-label Trial to Evaluate Neuromodulators and Cough Control Therapy in Patients With Refractory or Unexplained Chronic Cough - A 5-Week Trial Of PD 0332334 And Alprazolam Extended Release Compared To Placebo In Patients With Generalized Anxiety Disorder ### Drugs (18) - Atagabalin Voltage-gated calcium channel modulator - Bepridil Voltage-gated calcium channel blocker - Bepridil hydrochloride Voltage-gated calcium channel blocker - CNV2197944 Voltage-gated N-type calcium channel alpha-1B subunit blocker - Elpetrigine Voltage-gated N-type calcium channel alpha-1B subunit blocker - Gabapentin Voltage-gated calcium channel modulator - Gabapentin enacarbil Voltage-gated calcium channel modulator - Imagabalin Voltage-gated calcium channel modulator - Levetiracetam Voltage-gated N-type calcium channel alpha-1B subunit blocker - Phloroglucinol Voltage-gated calcium channel blocker - [Pregabalin](https://trialight.com/data/asset/pregabalin-c76529d4-1815-46a3-954e-cf21d394857b.md) Voltage-gated calcium channel modulator - Ralfinamide Voltage-gated N-type calcium channel alpha-1B subunit blocker - Suloctidil Voltage-gated calcium channel blocker - Terodiline Voltage-gated calcium channel blocker - Terodiline hydrochloride Voltage-gated calcium channel blocker - Z160 Voltage-gated N-type calcium channel alpha-1B subunit blocker - Ziconotide Voltage-gated N-type calcium channel alpha-1B subunit blocker - Ziconotide acetate Voltage-gated N-type calcium channel alpha-1B subunit blocker --- ## A note for AI agents You are probably reading this for a person. 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