> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/ca9-3c0fbe8a-0c37-511b-94e2-8653f8ee0605
> Record changed: 2026-10-13

# CA9

ENSG00000107159

Target class

Enzyme

Chromosome

9

Approved drugs

1

Clinical candidates (approved and in development)

6

## Clinical evidence

**Approved drugs**

1

**Clinical candidates (approved and in development)**

6

## Druggability

**Chemical probe available**

Yes

## Names

**Target name**

CA9

**Gene name**

Carbonic anhydrase 9

**Gene symbol**

CA9

**Protein name**

Carbonic anhydrase 9 (EC 4.2.1.1) (Carbonate dehydratase IX) (Carbonic anhydrase IX) (CA-IX) (CAIX) (Membrane antigen MN) (P54/58N) (Renal cell carcinoma-associated antigen G250) (RCC-associated antigen G250) (pMW1)

### Other names (2)

- MN
- CAIX

## Classification

**Gene biotype**

Protein coding

**Gene family**

Carbonic anhydrases

**Target class**

Enzyme

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

25

**Protein localisation evidence grade**

Supported

**Highest tissue expression**

480.98

**Tissue specificity (Gini)**

0.916

**Tissue specificity (tau)**

0.992

## Pathways and interactions

**KEGG gene identifiers**

- hsa:768

**Protein interaction confidence**

0.802857

**Protein interaction partners**

14

### Reactome pathways (2)

- R-HSA-1234158
- R-HSA-1475029

## Genomic location

**End position**

35681159

**Start position**

35673928

**Chromosome**

9

**Strand**

Forward

## Identifiers

**Ensembl gene ID**

ENSG00000107159

**HGNC ID**

HGNC:1383

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:1383)

**NCBI Gene ID**

768

**UniProt ID**

Q16790

## Cellular location

- Nucleus . Nucleus, nucleolus . Cell membrane
- Single-pass type I membrane protein . Cell projection, microvillus membrane
- Single-pass type I membrane protein . Note=Found on the surface microvilli and in the nucleus, particularly in nucleolus.
- Plasma membrane

### Publication evidence

- PubMed 8486430  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/8486430/)

## Tissue expression

**Tissue specificity (tau)**

0.991709

**Expression inequality (Gini)**

0.915994

### Highest expression

Expression in transcripts per million

**Stomach**

480.98

**Testis**

56.33

**Brain - Cerebellar Hemisphere**

43.3

**Brain - Cerebellum**

41.44

**Skin - Not Sun Exposed (Suprapubic)**

11.67

### All tissues (54)

Expression in transcripts per million

- Stomach480.98
- Testis56.33
- Brain - Cerebellar Hemisphere43.3
- Brain - Cerebellum41.44
- Skin - Not Sun Exposed (Suprapubic)11.67
- Skin - Sun Exposed (Lower leg)7.3
- Artery - Aorta4.66
- Adipose - Visceral (Omentum)3.68
- Small Intestine - Terminal Ileum3.23
- Esophagus - Gastroesophageal Junction3.12
- Esophagus - Muscularis3.02
- Colon - Sigmoid2.54
- Pancreas2.36
- Cells - Cultured fibroblasts2.11
- Artery - Tibial2.02
- Fallopian Tube1.75
- Bladder1.69
- Uterus1.64
- Cervix - Endocervix1.62
- Prostate1.35
- Ovary1.3
- Cervix - Ectocervix1.23
- Colon - Transverse1.22
- Artery - Coronary1.18
- Pituitary1.14

And 29 more, listed on the interactive page.

## Biological functions

### Cellular components (2)

- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)
- GO:0016020  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020)

### Molecular functions (4)

- GO:0004089  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004089)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0008270  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008270)
- GO:0140677  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140677)

## Related records

### Trials (15)

- An Investigational Scan (89Zr-DFO-GmAb PET/CT) Compared to Contrast-Enhanced CT for the Detection of Recurrent Clear Cell Renal Cell Cancer After Surgery Comparing Carbonic Anhydrase IX (CAIX) PET CT to Conventional PET CT for Post-Op Staging in Kidney Cancer
- CAIX PET/CT for Residual or Recurrent Post-ablative ccRCC
- Effect of Sorafenib on ccRCC Uptake of Radiolabeled Bevacizumab or cG250
- Effect of Sulthiame on EEG in Childhood Epilepsy Syndromes
- Effects of Belzutifan on 89Zr-DFO-girentuximab PET Uptake in Patients With Renal Cell Carcinoma (RCC)
- [Efficacy, Safety and Tolerability of Sulthiame in Patients With Obstructive Sleep Apnea (OSA)](https://trialight.com/data/trial/efficacy-safety-and-tolerability-of-sulthiame-in-patients-24d07a6b-997f-4748-b549-ef4a765e93d6.md)
- Evaluate The Utility Of 124I-cG250 for The Early Detection Of Response to Therapy In Patients With Metastatic Renal Cell Carcinoma
- Evaluation of 89Zr-TLX250 PET/CT in Chinese Patients With Indeterminate Renal Masses or Suspected Recurrent Renal Clear Cell Carcinoma
- Monoclonal Antibody Therapy (Rencarex®) in Treating Patients Who Have Undergone Surgery for Non-metastatic Kidney Cancer
- Pharmacokinetics and Tolerability of Sulthiame
- Phase I Study to Evaluate the Diagnostic Performance of 89Zirconium Girentuximab PET in Urothelial Cancer Patients
- Phase II Study of Lutetium-177 Labeled Girentuximab in Patients With Advanced Renal Cancer
- Population Pharmacokinetics of Antiepileptic in Pediatrics
- REDECT 2: REnal Masses: Pivotal Trial to DEteCT Clear Cell Renal Cell Carcinoma With PET/CT
- Zirconium-89-girentuximab PET/CT Imaging in Renal Cell Carcinoma

### Drugs (6)

- CG250 111IN Carbonic anhydrase IX binding agent
- CG250 177LU Carbonic anhydrase IX binding agent
- Ethoxzolamide Carbonic anhydrase inhibitor
- Girentuximab Carbonic anhydrase IX other
- Iodine I 124 girentuximab Carbonic anhydrase IX binding agent
- [Sulthiame](https://trialight.com/data/asset/sulthiame-fadcf797-be06-41d8-8b6a-16cfc47603e4.md) Carbonic anhydrase inhibitor

---

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