> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/ca7-8b7730a5-839f-5159-be45-c531a2ca465d
> Record changed: 2026-10-13

# CA7

ENSG00000168748

Target class

Enzyme

Chromosome

16

Approved drugs

2

Clinical candidates (approved and in development)

3

## Clinical evidence

**Approved drugs**

2

**Clinical candidates (approved and in development)**

3

## Druggability

**Chemical probe available**

Yes

## Names

**Target name**

CA7

**Gene name**

Carbonic anhydrase 7

**Gene symbol**

CA7

**Protein name**

Carbonic anhydrase 7 (EC 4.2.1.1) (Carbonate dehydratase VII) (Carbonic anhydrase VII) (CA-VII)

## Classification

**Gene biotype**

Protein coding

**Gene family**

Carbonic anhydrases

**Target class**

Enzyme

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

13

**Protein localisation evidence grade**

Approved

**Highest tissue expression**

32.96

**Tissue specificity (Gini)**

0.836

**Tissue specificity (tau)**

0.953

## Pathways and interactions

**KEGG gene identifiers**

- hsa:766

**Reactome pathways**

- R-HSA-1475029

**Protein interaction confidence**

0.7616

**Protein interaction partners**

5

## Genomic location

**End position**

66854153

**Start position**

66844414

**Chromosome**

16

**Strand**

Forward

## Identifiers

**Ensembl gene ID**

ENSG00000168748

**HGNC ID**

HGNC:1381

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:1381)

**NCBI Gene ID**

766

**UniProt ID**

P43166

## Cellular location

- Cytoplasm .
- Cytosol

## Tissue expression

**Tissue specificity (tau)**

0.953191

**Expression inequality (Gini)**

0.836035

### Highest expression

Expression in transcripts per million

**Colon - Transverse**

32.96

**Brain - Frontal Cortex (BA9)**

11.2

**Brain - Cortex**

10.86

**Brain - Caudate (basal ganglia)**

9.08

**Brain - Cerebellum**

7.94

### All tissues (54)

Expression in transcripts per million

- Colon - Transverse32.96
- Brain - Frontal Cortex (BA9)11.2
- Brain - Cortex10.86
- Brain - Caudate (basal ganglia)9.08
- Brain - Cerebellum7.94
- Brain - Putamen (basal ganglia)7.5
- Brain - Nucleus accumbens (basal ganglia)6.67
- Brain - Anterior cingulate cortex (BA24)6.61
- Brain - Hippocampus6.43
- Small Intestine - Terminal Ileum5.14
- Brain - Cerebellar Hemisphere3.2
- Brain - Amygdala3.16
- Testis1.36
- Brain - Hypothalamus0.45
- Brain - Substantia nigra0.33
- Brain - Spinal cord (cervical c-1)0.22
- Colon - Sigmoid0.19
- Thyroid0.15
- Pituitary0.15
- Uterus0.11
- Ovary0.1
- Prostate0.07
- Nerve - Tibial0.07
- Artery - Coronary0.06
- Fallopian Tube0.06

And 29 more, listed on the interactive page.

## Biological functions

### Cellular components

- GO:0005829  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829)

### Molecular functions

- GO:0004089  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004089)

## Related records

### Trials (14)

- Acamprosate and Methazolamide for Essential Tremor
- AZ, MZ, and the Pulmonary System Response to Hypoxia
- Effect of Acetazolamide and Methazolamide on Hypoxic Exercise Performance
- Effect of Sulthiame on EEG in Childhood Epilepsy Syndromes
- [Efficacy, Safety and Tolerability of Sulthiame in Patients With Obstructive Sleep Apnea (OSA)](https://trialight.com/data/trial/efficacy-safety-and-tolerability-of-sulthiame-in-patients-24d07a6b-997f-4748-b549-ef4a765e93d6.md)
- Improving Tumor Oxygenation in Cervical Cancer
- Muscle Fatigue and Carbonic Anhydrase Inhibitors
- Pharmacokinetics and Tolerability of Sulthiame
- Population Pharmacokinetics of Antiepileptic in Pediatrics
- Rapid Acclimatization to Hypoxia at Altitude
- Safety Evaluation of Aminophylline and Methazolamide
- Stop Retinal Ganglion Cell Dysfunction Study
- Three New Ideas to Protect Special Forces From the Stress of High Altitude
- Use of Methazolamide to Lower Intraocular Pressure

### Drugs (3)

- Ethoxzolamide Carbonic anhydrase inhibitor
- Methazolamide Carbonic anhydrase VII inhibitor
- [Sulthiame](https://trialight.com/data/asset/sulthiame-fadcf797-be06-41d8-8b6a-16cfc47603e4.md) Carbonic anhydrase inhibitor

---

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