CA7
ENSG00000168748
Target class
Enzyme
Chromosome
16
Approved drugs
2
Clinical candidates (approved and in development)
3
- Approved drugs
- 2
- Clinical candidates (approved and in development)
- 3
- Chemical probe available
- Yes
- Target name
- CA7
- Gene name
- Carbonic anhydrase 7
- Gene symbol
- CA7
- Protein name
- Carbonic anhydrase 7 (EC 4.2.1.1) (Carbonate dehydratase VII) (Carbonic anhydrase VII) (CA-VII)
- Gene biotype
- Protein coding
- Gene family
- Carbonic anhydrases
- Target class
- Enzyme
- Target type
- Human gene
- Tissues expressed in
- 13
- Protein localisation evidence grade
- Approved
- Highest tissue expression
- 32.96
- Tissue specificity (Gini)
- 0.836
- Tissue specificity (tau)
- 0.953
- KEGG gene identifiers
- hsa:766
- Reactome pathways
- R-HSA-1475029
- Protein interaction confidence
- 0.7616
- Protein interaction partners
- 5
- End position
- 66854153
- Start position
- 66844414
- Chromosome
- 16
- Strand
- Forward
- Cytoplasm .
- Cytosol
- Tissue specificity (tau)
- 0.953191
- Expression inequality (Gini)
- 0.836035
Expression in transcripts per million
- Colon - Transverse
- 32.96
- Brain - Frontal Cortex (BA9)
- 11.2
- Brain - Cortex
- 10.86
- Brain - Caudate (basal ganglia)
- 9.08
- Brain - Cerebellum
- 7.94
Expression in transcripts per million
- Colon - Transverse32.96
- Brain - Frontal Cortex (BA9)11.2
- Brain - Cortex10.86
- Brain - Caudate (basal ganglia)9.08
- Brain - Cerebellum7.94
- Brain - Putamen (basal ganglia)7.5
- Brain - Nucleus accumbens (basal ganglia)6.67
- Brain - Anterior cingulate cortex (BA24)6.61
- Brain - Hippocampus6.43
- Small Intestine - Terminal Ileum5.14
- Brain - Cerebellar Hemisphere3.2
- Brain - Amygdala3.16
- Testis1.36
- Brain - Hypothalamus0.45
- Brain - Substantia nigra0.33
- Brain - Spinal cord (cervical c-1)0.22
- Colon - Sigmoid0.19
- Thyroid0.15
- Pituitary0.15
- Uterus0.11
- Ovary0.1
- Prostate0.07
- Nerve - Tibial0.07
- Artery - Coronary0.06
- Fallopian Tube0.06
And 29 more, listed on the interactive page.
Cellular components
- GO:0005829
Molecular functions
- GO:0004089
Related records
Trials (14)
- Acamprosate and Methazolamide for Essential Tremor
- AZ, MZ, and the Pulmonary System Response to Hypoxia
- Effect of Acetazolamide and Methazolamide on Hypoxic Exercise Performance
- Effect of Sulthiame on EEG in Childhood Epilepsy Syndromes
- Efficacy, Safety and Tolerability of Sulthiame in Patients With Obstructive Sleep Apnea (OSA)
- Improving Tumor Oxygenation in Cervical Cancer
- Muscle Fatigue and Carbonic Anhydrase Inhibitors
- Pharmacokinetics and Tolerability of Sulthiame
- Population Pharmacokinetics of Antiepileptic in Pediatrics
- Rapid Acclimatization to Hypoxia at Altitude
- Safety Evaluation of Aminophylline and Methazolamide
- Stop Retinal Ganglion Cell Dysfunction Study
- Three New Ideas to Protect Special Forces From the Stress of High Altitude
- Use of Methazolamide to Lower Intraocular Pressure
Drugs (3)
- Ethoxzolamide Carbonic anhydrase inhibitor
- Methazolamide Carbonic anhydrase VII inhibitor
- Sulthiame Carbonic anhydrase inhibitor