> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/ca6-925b8f32-fa20-56fa-87ff-a19e9c6cffa1
> Record changed: 2026-10-13

# CA6

ENSG00000131686

Target class

Enzyme

Chromosome

1

Approved drugs

1

Clinical candidates (approved and in development)

2

## Clinical evidence

**Approved drugs**

1

**Clinical candidates (approved and in development)**

2

## Druggability

**Chemical probe available**

No

## Names

**Target name**

CA6

**Gene name**

Carbonic anhydrase 6

**Gene symbol**

CA6

**Protein name**

Carbonic anhydrase 6 (EC 4.2.1.1) (Carbonate dehydratase VI) (Carbonic anhydrase VI) (CA-VI) (Salivary carbonic anhydrase) (Secreted carbonic anhydrase)

## Classification

**Gene biotype**

Protein coding

**Gene family**

Carbonic anhydrases

**Target class**

Enzyme

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

2

**Highest tissue expression**

21.36

**Tissue specificity (Gini)**

0.965

**Tissue specificity (tau)**

0.989

## Pathways and interactions

**KEGG gene identifiers**

- hsa:765

**Reactome pathways**

- R-HSA-1475029

**Protein interaction confidence**

0.830167

**Protein interaction partners**

6

## Genomic location

**End position**

8975092

**Start position**

8945867

**Chromosome**

1

**Strand**

Forward

## Identifiers

**Ensembl gene ID**

ENSG00000131686

**HGNC ID**

HGNC:1380

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:1380)

**NCBI Gene ID**

765

**UniProt ID**

P23280

## Cellular location

- Secreted.

## Tissue expression

**Tissue specificity (tau)**

0.989488

**Expression inequality (Gini)**

0.964778

### Highest expression

Expression in transcripts per million

**Skin - Sun Exposed (Lower leg)**

21.36

**Skin - Not Sun Exposed (Suprapubic)**

11.26

**Spleen**

0.18

**Whole Blood**

0.08

**Pituitary**

0.08

### All tissues (54)

Expression in transcripts per million

- Skin - Sun Exposed (Lower leg)21.36
- Skin - Not Sun Exposed (Suprapubic)11.26
- Spleen0.18
- Whole Blood0.08
- Pituitary0.08
- Minor Salivary Gland0.07
- Testis0.06
- Breast - Mammary Tissue0.03
- Brain - Hippocampus0.02
- Thyroid0.01
- Small Intestine - Terminal Ileum0.01
- Brain - Spinal cord (cervical c-1)0.01
- Brain - Substantia nigra0.01
- Lung0.01
- Adipose - Subcutaneous0.01
- Esophagus - Mucosa0.01
- Brain - Amygdala0.01
- Cells - EBV-transformed lymphocytes0.01
- Nerve - Tibial0.01
- Brain - Hypothalamus0.01
- Brain - Caudate (basal ganglia)0.01
- Stomach0
- Prostate0
- Brain - Cerebellar Hemisphere0
- Cervix - Ectocervix0

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes

- GO:0001580  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001580)

### Cellular components (2)

- GO:0005576  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576)
- GO:0070062  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062)

### Molecular functions

- GO:0004089  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004089)

## Related records

### Trials (4)

- Effect of Sulthiame on EEG in Childhood Epilepsy Syndromes
- [Efficacy, Safety and Tolerability of Sulthiame in Patients With Obstructive Sleep Apnea (OSA)](https://trialight.com/data/trial/efficacy-safety-and-tolerability-of-sulthiame-in-patients-24d07a6b-997f-4748-b549-ef4a765e93d6.md)
- Pharmacokinetics and Tolerability of Sulthiame
- Population Pharmacokinetics of Antiepileptic in Pediatrics

### Drugs (2)

- Ethoxzolamide Carbonic anhydrase inhibitor
- [Sulthiame](https://trialight.com/data/asset/sulthiame-fadcf797-be06-41d8-8b6a-16cfc47603e4.md) Carbonic anhydrase inhibitor

---

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