> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/ca5b-55fba859-c8a2-595c-87a5-60e3f0a84dd3
> Record changed: 2026-10-13

# CA5B

ENSG00000169239

Target class

Enzyme

Chromosome

X

Approved drugs

1

Clinical candidates (approved and in development)

2

## Clinical evidence

**Approved drugs**

1

**Clinical candidates (approved and in development)**

2

## Druggability

**Chemical probe available**

No

## Names

**Target name**

CA5B

**Gene name**

Carbonic anhydrase 5B

**Gene symbol**

CA5B

**Protein name**

Carbonic anhydrase 5B, mitochondrial (EC 4.2.1.1) (Carbonate dehydratase VB) (Carbonic anhydrase VB) (CA-VB)

## Classification

**Gene biotype**

Protein coding

**Gene family**

Carbonic anhydrases

**Target class**

Enzyme

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

51

**Protein localisation evidence grade**

Supported

**Highest tissue expression**

14.52

**Tissue specificity (Gini)**

0.377

**Tissue specificity (tau)**

0.708

## Pathways and interactions

**KEGG gene identifiers**

- hsa:11238

**Reactome pathways**

- R-HSA-1475029

**Protein interaction confidence**

0.8045

**Protein interaction partners**

2

## Genomic location

**End position**

15788411

**Start position**

15688830

**Chromosome**

X

**Strand**

Forward

## Identifiers

**Ensembl gene ID**

ENSG00000169239

**HGNC ID**

HGNC:1378

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:1378)

**NCBI Gene ID**

11238

**UniProt ID**

Q9Y2D0

## Cellular location

- Mitochondrion .
- Mitochondria

### Publication evidence

- PubMed 10409679  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/10409679/)

## Tissue expression

**Tissue specificity (tau)**

0.708223

**Expression inequality (Gini)**

0.377416

### Highest expression

Expression in transcripts per million

**Artery - Aorta**

14.52

**Cervix - Ectocervix**

14.17

**Testis**

11.98

**Artery - Tibial**

11.69

**Artery - Coronary**

10.16

### All tissues (54)

Expression in transcripts per million

- Artery - Aorta14.52
- Cervix - Ectocervix14.17
- Testis11.98
- Artery - Tibial11.69
- Artery - Coronary10.16
- Cervix - Endocervix9.82
- Ovary8.86
- Vagina7.23
- Nerve - Tibial7.2
- Uterus6.96
- Adipose - Subcutaneous6.53
- Breast - Mammary Tissue6.07
- Thyroid5.67
- Fallopian Tube5.58
- Skin - Sun Exposed (Lower leg)5.12
- Lung4.94
- Prostate4.58
- Minor Salivary Gland4.51
- Brain - Substantia nigra4.38
- Skin - Not Sun Exposed (Suprapubic)4.3
- Bladder4.21
- Adipose - Visceral (Omentum)3.77
- Cells - Cultured fibroblasts3.75
- Esophagus - Gastroesophageal Junction3.67
- Brain - Nucleus accumbens (basal ganglia)3.64

And 29 more, listed on the interactive page.

## Biological functions

### Cellular components (2)

- GO:0005739  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005739)
- GO:0005759  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005759)

### Molecular functions (2)

- GO:0004089  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004089)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)

## Related records

### Trials (4)

- Effect of Sulthiame on EEG in Childhood Epilepsy Syndromes
- [Efficacy, Safety and Tolerability of Sulthiame in Patients With Obstructive Sleep Apnea (OSA)](https://trialight.com/data/trial/efficacy-safety-and-tolerability-of-sulthiame-in-patients-24d07a6b-997f-4748-b549-ef4a765e93d6.md)
- Pharmacokinetics and Tolerability of Sulthiame
- Population Pharmacokinetics of Antiepileptic in Pediatrics

### Drugs (2)

- Ethoxzolamide Carbonic anhydrase inhibitor
- [Sulthiame](https://trialight.com/data/asset/sulthiame-fadcf797-be06-41d8-8b6a-16cfc47603e4.md) Carbonic anhydrase inhibitor

---

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