> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/ca5a-714d898f-f9c7-5b92-8d05-ce884378802e
> Record changed: 2026-10-13

# CA5A

ENSG00000174990

Target class

Enzyme

Chromosome

16

Approved drugs

1

Clinical candidates (approved and in development)

2

## Clinical evidence

**Approved drugs**

1

**ClinGen gene-disease validity**

Definitive

**Clinical candidates (approved and in development)**

2

## Druggability

**Chemical probe available**

No

## Names

**Target name**

CA5A

**Gene name**

Carbonic anhydrase 5A

**Gene symbol**

CA5A

**Previous gene symbols**

- CA5

**Protein name**

Carbonic anhydrase 5A, mitochondrial (EC 4.2.1.1) (Carbonate dehydratase VA) (Carbonic anhydrase VA) (CA-VA)

### Other names (3)

- CA5
- CAV
- CAVA

## Classification

**Gene biotype**

Protein coding

**Gene family**

Carbonic anhydrases

**Target class**

Enzyme

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

1

**Highest tissue expression**

6.39

**Tissue specificity (Gini)**

0.905

**Tissue specificity (tau)**

0.995

## Pathways and interactions

**KEGG gene identifiers**

- hsa:763

**Reactome pathways**

- R-HSA-1475029

**Protein interaction confidence**

0.7915

**Protein interaction partners**

2

## Genomic location

**End position**

87936580

**Start position**

87881546

**Chromosome**

16

**Strand**

Reverse

## Identifiers

**Ensembl gene ID**

ENSG00000174990

**HGNC ID**

HGNC:1377

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:1377)

**NCBI Gene ID**

763

**UniProt ID**

P35218

## Cellular location

- Mitochondrion .

### Publication evidence

- PubMed 8356065  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/8356065/)

## Tissue expression

**Tissue specificity (tau)**

0.995453

**Expression inequality (Gini)**

0.904605

### Highest expression

Expression in transcripts per million

**Liver**

6.39

**Brain - Substantia nigra**

0.12

**Brain - Spinal cord (cervical c-1)**

0.11

**Brain - Hypothalamus**

0.11

**Brain - Hippocampus**

0.1

### All tissues (54)

Expression in transcripts per million

- Liver6.39
- Brain - Substantia nigra0.12
- Brain - Spinal cord (cervical c-1)0.11
- Brain - Hypothalamus0.11
- Brain - Hippocampus0.1
- Brain - Cortex0.09
- Brain - Frontal Cortex (BA9)0.09
- Brain - Putamen (basal ganglia)0.09
- Brain - Cerebellum0.09
- Brain - Anterior cingulate cortex (BA24)0.08
- Brain - Caudate (basal ganglia)0.08
- Brain - Cerebellar Hemisphere0.08
- Brain - Amygdala0.07
- Testis0.06
- Brain - Nucleus accumbens (basal ganglia)0.06
- Ovary0.03
- Thyroid0.02
- Cervix - Endocervix0.02
- Heart - Left Ventricle0.01
- Lung0.01
- Nerve - Tibial0.01
- Kidney - Medulla0.01
- Pituitary0.01
- Spleen0.01
- Cells - EBV-transformed lymphocytes0.01

And 29 more, listed on the interactive page.

## Biological functions

### Cellular components (2)

- GO:0005739  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005739)
- GO:0005759  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005759)

### Molecular functions

- GO:0004089  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004089)

## Related records

### Trials (4)

- Effect of Sulthiame on EEG in Childhood Epilepsy Syndromes
- [Efficacy, Safety and Tolerability of Sulthiame in Patients With Obstructive Sleep Apnea (OSA)](https://trialight.com/data/trial/efficacy-safety-and-tolerability-of-sulthiame-in-patients-24d07a6b-997f-4748-b549-ef4a765e93d6.md)
- Pharmacokinetics and Tolerability of Sulthiame
- Population Pharmacokinetics of Antiepileptic in Pediatrics

### Drugs (2)

- Ethoxzolamide Carbonic anhydrase inhibitor
- [Sulthiame](https://trialight.com/data/asset/sulthiame-fadcf797-be06-41d8-8b6a-16cfc47603e4.md) Carbonic anhydrase inhibitor

---

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