CA5A
ENSG00000174990
Target class
Enzyme
Chromosome
16
Approved drugs
1
Clinical candidates (approved and in development)
2
- Approved drugs
- 1
- ClinGen gene-disease validity
- Definitive
- Clinical candidates (approved and in development)
- 2
- Chemical probe available
- No
- Target name
- CA5A
- Gene name
- Carbonic anhydrase 5A
- Gene symbol
- CA5A
- Previous gene symbols
- CA5
- Protein name
- Carbonic anhydrase 5A, mitochondrial (EC 4.2.1.1) (Carbonate dehydratase VA) (Carbonic anhydrase VA) (CA-VA)
- CA5
- CAV
- CAVA
- Gene biotype
- Protein coding
- Gene family
- Carbonic anhydrases
- Target class
- Enzyme
- Target type
- Human gene
- Tissues expressed in
- 1
- Highest tissue expression
- 6.39
- Tissue specificity (Gini)
- 0.905
- Tissue specificity (tau)
- 0.995
- KEGG gene identifiers
- hsa:763
- Reactome pathways
- R-HSA-1475029
- Protein interaction confidence
- 0.7915
- Protein interaction partners
- 2
- End position
- 87936580
- Start position
- 87881546
- Chromosome
- 16
- Strand
- Reverse
- Mitochondrion .
Publication evidence
- PubMed 8356065
- Tissue specificity (tau)
- 0.995453
- Expression inequality (Gini)
- 0.904605
Expression in transcripts per million
- Liver
- 6.39
- Brain - Substantia nigra
- 0.12
- Brain - Spinal cord (cervical c-1)
- 0.11
- Brain - Hypothalamus
- 0.11
- Brain - Hippocampus
- 0.1
Expression in transcripts per million
- Liver6.39
- Brain - Substantia nigra0.12
- Brain - Spinal cord (cervical c-1)0.11
- Brain - Hypothalamus0.11
- Brain - Hippocampus0.1
- Brain - Cortex0.09
- Brain - Frontal Cortex (BA9)0.09
- Brain - Putamen (basal ganglia)0.09
- Brain - Cerebellum0.09
- Brain - Anterior cingulate cortex (BA24)0.08
- Brain - Caudate (basal ganglia)0.08
- Brain - Cerebellar Hemisphere0.08
- Brain - Amygdala0.07
- Testis0.06
- Brain - Nucleus accumbens (basal ganglia)0.06
- Ovary0.03
- Thyroid0.02
- Cervix - Endocervix0.02
- Heart - Left Ventricle0.01
- Lung0.01
- Nerve - Tibial0.01
- Kidney - Medulla0.01
- Pituitary0.01
- Spleen0.01
- Cells - EBV-transformed lymphocytes0.01
And 29 more, listed on the interactive page.
- GO:0005739
- GO:0005759
Molecular functions
- GO:0004089
Related records
Trials (4)
- Effect of Sulthiame on EEG in Childhood Epilepsy Syndromes
- Efficacy, Safety and Tolerability of Sulthiame in Patients With Obstructive Sleep Apnea (OSA)
- Pharmacokinetics and Tolerability of Sulthiame
- Population Pharmacokinetics of Antiepileptic in Pediatrics
Drugs (2)
- Ethoxzolamide Carbonic anhydrase inhibitor
- Sulthiame Carbonic anhydrase inhibitor