> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/ca4-1d821d4b-b693-590c-817c-217c1f430e85 > Record changed: 2026-10-13 # CA4 ENSG00000167434 Target class Enzyme Chromosome 17 Approved drugs 6 Clinical candidates (approved and in development) 7 ## Clinical evidence **Approved drugs** 6 **Clinical candidates (approved and in development)** 7 ## Druggability **Chemical probe available** Yes ## Names **Target name** CA4 **Gene name** Carbonic anhydrase 4 **Gene symbol** CA4 **Previous gene symbols** - RP17 **Protein name** Carbonic anhydrase 4 (EC 4.2.1.1) (Carbonate dehydratase IV) (Carbonic anhydrase IV) (CA-IV) ### Other names (2) - CAIV - Car4 ## Classification **Gene biotype** Protein coding **Gene family** Carbonic anhydrases **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 49 **Protein localisation evidence grade** Uncertain **Highest tissue expression** 110.33 **Tissue specificity (Gini)** 0.676 **Tissue specificity (tau)** 0.886 ## Pathways and interactions **KEGG gene identifiers** - hsa:762 **Protein interaction confidence** 0.758429 **Protein interaction partners** 7 ### Reactome pathways (3) - R-HSA-1237044 - R-HSA-1247673 - R-HSA-1475029 ## Genomic location **End position** 60170899 **Start position** 60147838 **Chromosome** 17 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000167434 **HGNC ID** HGNC:1375 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:1375) **NCBI Gene ID** 762 **UniProt ID** P22748 ## Cellular location - Cell membrane - Lipid-anchor, GPI-anchor . ### Publication evidence (2) - PubMed 15563508 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/15563508/) - PubMed 7625839 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/7625839/) ## Tissue expression **Tissue specificity (tau)** 0.88551 **Expression inequality (Gini)** 0.676074 ### Highest expression Expression in transcripts per million **Brain - Cerebellar Hemisphere** 110.33 **Brain - Cerebellum** 103.16 **Lung** 71 **Thyroid** 68.7 **Adipose - Visceral (Omentum)** 54.13 ### All tissues (54) Expression in transcripts per million - Brain - Cerebellar Hemisphere110.33 - Brain - Cerebellum103.16 - Lung71 - Thyroid68.7 - Adipose - Visceral (Omentum)54.13 - Breast - Mammary Tissue47.5 - Whole Blood36.18 - Adipose - Subcutaneous34 - Colon - Transverse27.74 - Kidney - Cortex18.39 - Kidney - Medulla16.35 - Brain - Cortex14.92 - Brain - Frontal Cortex (BA9)13.07 - Pituitary12.53 - Spleen10.85 - Heart - Left Ventricle9.74 - Pancreas8.43 - Brain - Anterior cingulate cortex (BA24)7.19 - Uterus5.9 - Prostate5.61 - Brain - Hippocampus5.33 - Brain - Putamen (basal ganglia)5.21 - Stomach5.08 - Brain - Substantia nigra4.91 - Vagina4.77 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes - GO:0015701 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015701) ### Cellular components (15) - GO:0005791 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005791) - GO:0005793 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005793) - GO:0005794 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005794) - GO:0005802 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005802) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0009897 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009897) - GO:0009986 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009986) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) - GO:0016323 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016323) - GO:0016324 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016324) - GO:0030658 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030658) - GO:0030667 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030667) - GO:0031526 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031526) - GO:0048471 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048471) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) ### Molecular functions (2) - GO:0004089 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004089) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (426) - A Combined Surgical and Medical Approach in Mild Sleep Apnea - A Comparison of the Effectiveness and Safety of Topiramate and Phenytoin in Patients With New Onset Epilepsy Requiring Rapid Initiation of Antiepileptic Drug Treatment - A Comparison of the Efficacy and Safety of Topiramate Versus Placebo in Preventing Migraine Headaches in Children - A Comparison of the Efficacy and Safety of Topiramate Versus Placebo in Treating Tremor of Unknown Cause. - A Controlled Trial of Topiramate Treatment for Alcohol Dependence in Veterans With PTSD - A Conversion Study of Immediate Release (IR) and Modified Release (MR) Forms of Topiramate (TPM) - A Cross-sectional Study to Investigate the Effect of Topiramate on Bone and Mineral Metabolism in Female Participants With Epilepsy - A Dose-Finding Study of Topiramate (JNS019) in Participants With Migraine - A Double-Blind, Placebo-Controlled Study Examining the Use of Topiramate in the Treatment of Cluster Headache - A Drug Interaction Study of the Pharmacokinetics of Topiramate and FLUNARIZINE When Given Together or Separately - A Multicenter Comparative Trial of Zonisamide and Topiramate as Initial Monotherapy in Untreated Epilepsies - A Noninvasive Arterial Input Estimation Method for O-15 PET and Integrated PET/MR Scanning - A Open-label, Drug Interaction Study Between Eslicarbazepine Acetate and Topiramate - A Pharmacokinetic Study of Lithium Before and During Topiramate Dosing in Bipolar Disorder Patients - A Pharmacokinetic Study of Risperidone and Topiramate Administered Alone and in Combination in Patients With Bipolar Disorder or Schizoaffective Disorders - A Phase 1 Bioavailability Study of Topiramate Oral Liquid Formulation Compared to the Marketed Sprinkle Capsule Formulation in Healthy Adults - A Phase 3, Double-blind/Double-dummy, Safety/Efficacy/Superiority of Sibutramine/Topiramate XR in Adults With Overweight - A Pilot Study of the Neural Correlates of Treatment Effect on Nicotine Craving - A Pilot Study of Topiramate in Childhood Absence Epilepsy - A Placebo-Controlled Study of Mixed Amphetamine Salts and Topiramate for the Treatment of Cocaine Dependence ### Drugs (7) - Acetazolamide Carbonic anhydrase IV inhibitor - Acetazolamide sodium Carbonic anhydrase IV inhibitor - Dichlorphenamide Carbonic anhydrase IV inhibitor - Ethoxzolamide Carbonic anhydrase inhibitor - Methazolamide Carbonic anhydrase IV inhibitor - [Sulthiame](https://trialight.com/data/asset/sulthiame-fadcf797-be06-41d8-8b6a-16cfc47603e4.md) Carbonic anhydrase inhibitor - Topiramate Carbonic anhydrase IV inhibitor --- ## A note for AI agents You are probably reading this for a person. 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