CA4
ENSG00000167434
Target class
Enzyme
Chromosome
17
Approved drugs
6
Clinical candidates (approved and in development)
7
- Approved drugs
- 6
- Clinical candidates (approved and in development)
- 7
- Chemical probe available
- Yes
- Target name
- CA4
- Gene name
- Carbonic anhydrase 4
- Gene symbol
- CA4
- Previous gene symbols
- RP17
- Protein name
- Carbonic anhydrase 4 (EC 4.2.1.1) (Carbonate dehydratase IV) (Carbonic anhydrase IV) (CA-IV)
- CAIV
- Car4
- Gene biotype
- Protein coding
- Gene family
- Carbonic anhydrases
- Target class
- Enzyme
- Target type
- Human gene
- Tissues expressed in
- 49
- Protein localisation evidence grade
- Uncertain
- Highest tissue expression
- 110.33
- Tissue specificity (Gini)
- 0.676
- Tissue specificity (tau)
- 0.886
- KEGG gene identifiers
- hsa:762
- Protein interaction confidence
- 0.758429
- Protein interaction partners
- 7
- R-HSA-1237044
- R-HSA-1247673
- R-HSA-1475029
- End position
- 60170899
- Start position
- 60147838
- Chromosome
- 17
- Strand
- Forward
- Cell membrane
- Lipid-anchor, GPI-anchor .
- PubMed 15563508
- PubMed 7625839
- Tissue specificity (tau)
- 0.88551
- Expression inequality (Gini)
- 0.676074
Expression in transcripts per million
- Brain - Cerebellar Hemisphere
- 110.33
- Brain - Cerebellum
- 103.16
- Lung
- 71
- Thyroid
- 68.7
- Adipose - Visceral (Omentum)
- 54.13
Expression in transcripts per million
- Brain - Cerebellar Hemisphere110.33
- Brain - Cerebellum103.16
- Lung71
- Thyroid68.7
- Adipose - Visceral (Omentum)54.13
- Breast - Mammary Tissue47.5
- Whole Blood36.18
- Adipose - Subcutaneous34
- Colon - Transverse27.74
- Kidney - Cortex18.39
- Kidney - Medulla16.35
- Brain - Cortex14.92
- Brain - Frontal Cortex (BA9)13.07
- Pituitary12.53
- Spleen10.85
- Heart - Left Ventricle9.74
- Pancreas8.43
- Brain - Anterior cingulate cortex (BA24)7.19
- Uterus5.9
- Prostate5.61
- Brain - Hippocampus5.33
- Brain - Putamen (basal ganglia)5.21
- Stomach5.08
- Brain - Substantia nigra4.91
- Vagina4.77
And 29 more, listed on the interactive page.
Biological processes
- GO:0015701
- GO:0005791
- GO:0005793
- GO:0005794
- GO:0005802
- GO:0005886
- GO:0009897
- GO:0009986
- GO:0016020
- GO:0016323
- GO:0016324
- GO:0030658
- GO:0030667
- GO:0031526
- GO:0048471
- GO:0070062
- GO:0004089
- GO:0005515
Related records
Trials (426)
- A Combined Surgical and Medical Approach in Mild Sleep Apnea
- A Comparison of the Effectiveness and Safety of Topiramate and Phenytoin in Patients With New Onset Epilepsy Requiring Rapid Initiation of Antiepileptic Drug Treatment
- A Comparison of the Efficacy and Safety of Topiramate Versus Placebo in Preventing Migraine Headaches in Children
- A Comparison of the Efficacy and Safety of Topiramate Versus Placebo in Treating Tremor of Unknown Cause.
- A Controlled Trial of Topiramate Treatment for Alcohol Dependence in Veterans With PTSD
- A Conversion Study of Immediate Release (IR) and Modified Release (MR) Forms of Topiramate (TPM)
- A Cross-sectional Study to Investigate the Effect of Topiramate on Bone and Mineral Metabolism in Female Participants With Epilepsy
- A Dose-Finding Study of Topiramate (JNS019) in Participants With Migraine
- A Double-Blind, Placebo-Controlled Study Examining the Use of Topiramate in the Treatment of Cluster Headache
- A Drug Interaction Study of the Pharmacokinetics of Topiramate and FLUNARIZINE When Given Together or Separately
- A Multicenter Comparative Trial of Zonisamide and Topiramate as Initial Monotherapy in Untreated Epilepsies
- A Noninvasive Arterial Input Estimation Method for O-15 PET and Integrated PET/MR Scanning
- A Open-label, Drug Interaction Study Between Eslicarbazepine Acetate and Topiramate
- A Pharmacokinetic Study of Lithium Before and During Topiramate Dosing in Bipolar Disorder Patients
- A Pharmacokinetic Study of Risperidone and Topiramate Administered Alone and in Combination in Patients With Bipolar Disorder or Schizoaffective Disorders
- A Phase 1 Bioavailability Study of Topiramate Oral Liquid Formulation Compared to the Marketed Sprinkle Capsule Formulation in Healthy Adults
- A Phase 3, Double-blind/Double-dummy, Safety/Efficacy/Superiority of Sibutramine/Topiramate XR in Adults With Overweight
- A Pilot Study of the Neural Correlates of Treatment Effect on Nicotine Craving
- A Pilot Study of Topiramate in Childhood Absence Epilepsy
- A Placebo-Controlled Study of Mixed Amphetamine Salts and Topiramate for the Treatment of Cocaine Dependence
Drugs (7)
- Acetazolamide Carbonic anhydrase IV inhibitor
- Acetazolamide sodium Carbonic anhydrase IV inhibitor
- Dichlorphenamide Carbonic anhydrase IV inhibitor
- Ethoxzolamide Carbonic anhydrase inhibitor
- Methazolamide Carbonic anhydrase IV inhibitor
- Sulthiame Carbonic anhydrase inhibitor
- Topiramate Carbonic anhydrase IV inhibitor