> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/ca2-55428057-ad67-536c-a052-6c9af9d2b876 > Record changed: 2026-10-13 # CA2 ENSG00000104267 Target class Enzyme Chromosome 8 Approved drugs 8 Clinical candidates (approved and in development) 10 ## Clinical evidence **Approved drugs** 8 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 10 ## Druggability **Chemical probe available** Yes ## Names **Target name** CA2 **Gene name** Carbonic anhydrase 2 **Gene symbol** CA2 **Protein name** Carbonic anhydrase 2 (EC 4.2.1.1) (Carbonate dehydratase II) (Carbonic anhydrase C) (CAC) (Carbonic anhydrase II) (CA-II) (Cyanamide hydratase CA2) (EC 4.2.1.69) ### Other names (3) - Car2 - CA-II - CAII ## Classification **Gene biotype** Protein coding **Gene family** Carbonic anhydrases **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 52 **Highest tissue expression** 273.65 **Tissue specificity (Gini)** 0.645 **Tissue specificity (tau)** 0.872 ## Pathways and interactions **KEGG gene identifiers** - hsa:760 **Protein interaction confidence** 0.8174 **Protein interaction partners** 20 ### Reactome pathways (4) - R-HSA-1237044 - R-HSA-1247673 - R-HSA-1475029 - R-HSA-9925563 ## Genomic location **End position** 85481493 **Start position** 85463968 **Chromosome** 8 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000104267 **HGNC ID** HGNC:1373 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:1373) **NCBI Gene ID** 760 **UniProt ID** P00918 ## Cellular location - Cytoplasm . Cell membrane . Note=Colocalized with SLC26A6 at the surface of the cell membrane in order to form a bicarbonate transport metabolon. Displaced from the cytosolic surface of the cell membrane by PKC in phorbol myristate acetate (PMA)-induced cells. . ### Publication evidence - PubMed 15990874 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/15990874/) ## Tissue expression **Tissue specificity (tau)** 0.872463 **Expression inequality (Gini)** 0.645326 ### Highest expression Expression in transcripts per million **Stomach** 273.65 **Colon - Transverse** 253.34 **Kidney - Cortex** 138.41 **Kidney - Medulla** 134.87 **Brain - Spinal cord (cervical c-1)** 116.81 ### All tissues (54) Expression in transcripts per million - Stomach273.65 - Colon - Transverse253.34 - Kidney - Cortex138.41 - Kidney - Medulla134.87 - Brain - Spinal cord (cervical c-1)116.81 - Brain - Putamen (basal ganglia)99.47 - Brain - Caudate (basal ganglia)81.63 - Testis80.85 - Brain - Substantia nigra76.48 - Brain - Hippocampus73.95 - Brain - Amygdala73.08 - Liver64.17 - Minor Salivary Gland56.68 - Skin - Not Sun Exposed (Suprapubic)52.93 - Brain - Nucleus accumbens (basal ganglia)52.49 - Brain - Hypothalamus50.3 - Brain - Frontal Cortex (BA9)47.77 - Brain - Cortex45.57 - Brain - Anterior cingulate cortex (BA24)39.94 - Lung31.64 - Skin - Sun Exposed (Lower leg)27.11 - Muscle - Skeletal26.65 - Esophagus - Mucosa22.79 - Thyroid21.28 - Brain - Cerebellum18.2 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (2) - GO:0038166 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038166) - GO:0044070 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0044070) ### Cellular components (5) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0045177 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045177) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) ### Molecular functions (5) - GO:0004064 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004064) - GO:0004089 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004089) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0008270 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008270) - GO:0018820 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0018820) ## Related records ### Trials (539) - 1 Year Study Trav/Brinz QD Fixed Combination Versus COSOPT - 24-hour Efficacy and Ocular Surface With Talfuprost and Triple Combined Therapy - 24-Hour Intraocular Pressure With Brinzolamide/Timolol Versus Brimonidine/Timolol - 24-hour Study of Dorzolamide/Timolol and Latanoprost/Timolol Fixed Combinations - 24-hr Intraocular Pressure Control With SIMBRINZA ® - 6-Week Proof-of-Concept Study of Travoprost/Brinzolamide Ophthalmic Suspension in Subjects With Open-Angle Glaucoma or Ocular Hypertension - A Combined Surgical and Medical Approach in Mild Sleep Apnea - A Comfort Study of Brinzolamide 1% / Brimonidine 0.2% Fixed Combination, Brinzolamide 1% and Brimonidine 0.2% - A Comparison of Azopt Versus Placebo Added to Xalatan in Patients With Elevated Intraocular Pressure (IOP) on a Prostaglandin - A Comparison of the Effect of Dorzolamide and Timolol on Optic Disk Blood Flow in Patients With Open Angle Glaucoma - A Comparison of the Effectiveness and Safety of Topiramate and Phenytoin in Patients With New Onset Epilepsy Requiring Rapid Initiation of Antiepileptic Drug Treatment - A Comparison of the Efficacy and Safety of Topiramate Versus Placebo in Preventing Migraine Headaches in Children - A Comparison of the Efficacy and Safety of Topiramate Versus Placebo in Treating Tremor of Unknown Cause. - A Controlled Trial of Topiramate Treatment for Alcohol Dependence in Veterans With PTSD - A Conversion Study of Immediate Release (IR) and Modified Release (MR) Forms of Topiramate (TPM) - A Cross-sectional Study to Investigate the Effect of Topiramate on Bone and Mineral Metabolism in Female Participants With Epilepsy - A Dose-Finding Study of Topiramate (JNS019) in Participants With Migraine - A Double-Blind, Placebo-Controlled Study Examining the Use of Topiramate in the Treatment of Cluster Headache - A Drug Interaction Study of the Pharmacokinetics of Topiramate and FLUNARIZINE When Given Together or Separately - A Multicenter Comparative Trial of Zonisamide and Topiramate as Initial Monotherapy in Untreated Epilepsies ### Drugs (11) - Acetazolamide Carbonic anhydrase II inhibitor - Acetazolamide sodium Carbonic anhydrase II inhibitor - Brinzolamide Carbonic anhydrase II inhibitor - Dichlorphenamide Carbonic anhydrase II inhibitor - Dorzolamide Carbonic anhydrase II inhibitor - Dorzolamide hydrochloride Carbonic anhydrase II inhibitor - Ethoxzolamide Carbonic anhydrase inhibitor - Methazolamide Carbonic anhydrase II inhibitor - Polmacoxib Carbonic anhydrase II inhibitor - [Sulthiame](https://trialight.com/data/asset/sulthiame-fadcf797-be06-41d8-8b6a-16cfc47603e4.md) Carbonic anhydrase inhibitor - Topiramate Carbonic anhydrase II inhibitor --- ## A note for AI agents You are probably reading this for a person. 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