CA14
ENSG00000118298
Target class
Enzyme
Chromosome
1
Approved drugs
1
Clinical candidates (approved and in development)
2
- Approved drugs
- 1
- Clinical candidates (approved and in development)
- 2
- Chemical probe available
- No
- Target name
- CA14
- Gene name
- Carbonic anhydrase 14
- Gene symbol
- CA14
- Protein name
- Carbonic anhydrase 14 (EC 4.2.1.1) (Carbonate dehydratase XIV) (Carbonic anhydrase XIV) (CA-XIV)
- Gene biotype
- Protein coding
- Gene family
- Carbonic anhydrases
- Target class
- Enzyme
- Target type
- Human gene
- Tissues expressed in
- 26
- Protein localisation evidence grade
- Approved
- Highest tissue expression
- 37.24
- Tissue specificity (Gini)
- 0.702
- Tissue specificity (tau)
- 0.955
- KEGG gene identifiers
- hsa:23632
- Reactome pathways
- R-HSA-1475029
- Protein interaction confidence
- 0.85
- Protein interaction partners
- 1
- End position
- 150265078
- Start position
- 150257251
- Chromosome
- 1
- Strand
- Forward
- Membrane
- Single-pass type I membrane protein .
- Plasma membrane
- Tissue specificity (tau)
- 0.955287
- Expression inequality (Gini)
- 0.701527
Expression in transcripts per million
- Brain - Spinal cord (cervical c-1)
- 37.24
- Brain - Substantia nigra
- 11.41
- Brain - Hippocampus
- 6.33
- Brain - Putamen (basal ganglia)
- 5.68
- Brain - Caudate (basal ganglia)
- 4.57
Expression in transcripts per million
- Brain - Spinal cord (cervical c-1)37.24
- Brain - Substantia nigra11.41
- Brain - Hippocampus6.33
- Brain - Putamen (basal ganglia)5.68
- Brain - Caudate (basal ganglia)4.57
- Brain - Amygdala4.55
- Colon - Sigmoid4.48
- Brain - Hypothalamus4.38
- Heart - Atrial Appendage3.93
- Brain - Cerebellum3.83
- Brain - Cerebellar Hemisphere3.43
- Brain - Nucleus accumbens (basal ganglia)3.22
- Brain - Cortex3.21
- Brain - Frontal Cortex (BA9)2.97
- Heart - Left Ventricle2.52
- Brain - Anterior cingulate cortex (BA24)2.23
- Skin - Sun Exposed (Lower leg)1.9
- Skin - Not Sun Exposed (Suprapubic)1.65
- Nerve - Tibial1.64
- Prostate1.63
- Ovary1.5
- Fallopian Tube1.35
- Colon - Transverse1.33
- Esophagus - Muscularis1.24
- Esophagus - Gastroesophageal Junction1.1
And 29 more, listed on the interactive page.
- GO:0005886
- GO:0016020
Molecular functions
- GO:0004089
Related records
Trials (4)
- Effect of Sulthiame on EEG in Childhood Epilepsy Syndromes
- Efficacy, Safety and Tolerability of Sulthiame in Patients With Obstructive Sleep Apnea (OSA)
- Pharmacokinetics and Tolerability of Sulthiame
- Population Pharmacokinetics of Antiepileptic in Pediatrics
Drugs (2)
- Ethoxzolamide Carbonic anhydrase inhibitor
- Sulthiame Carbonic anhydrase inhibitor