> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/ca13-523371a9-d99d-5ce6-a422-1a05c0e07957
> Record changed: 2026-10-13

# CA13

ENSG00000185015

Target class

Enzyme

Chromosome

8

Approved drugs

1

Clinical candidates (approved and in development)

2

## Clinical evidence

**Approved drugs**

1

**Clinical candidates (approved and in development)**

2

## Druggability

**Chemical probe available**

No

## Names

**Target name**

CA13

**Gene name**

Carbonic anhydrase 13

**Gene symbol**

CA13

**Protein name**

Carbonic anhydrase 13 (EC 4.2.1.1) (Carbonate dehydratase XIII) (Carbonic anhydrase XIII) (CA-XIII)

### Other names (3)

- CAXIII
- FLJ37995
- MGC59868

## Classification

**Gene biotype**

Protein coding

**Gene family**

Carbonic anhydrases

**Target class**

Enzyme

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

43

**Protein localisation evidence grade**

Approved

**Highest tissue expression**

8.39

**Tissue specificity (Gini)**

0.416

**Tissue specificity (tau)**

0.707

## Pathways and interactions

**KEGG gene identifiers**

- hsa:377677

**Reactome pathways**

- R-HSA-1475029

**Protein interaction confidence**

0.854

**Protein interaction partners**

1

## Genomic location

**End position**

85284073

**Start position**

85220587

**Chromosome**

8

**Strand**

Forward

## Identifiers

**Ensembl gene ID**

ENSG00000185015

**HGNC ID**

HGNC:14914

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:14914)

**NCBI Gene ID**

377677

**UniProt ID**

Q8N1Q1

## Cellular location

- Nucleoli
- Nucleoplasm
- Vesicles

## Tissue expression

**Tissue specificity (tau)**

0.707423

**Expression inequality (Gini)**

0.415999

### Highest expression

Expression in transcripts per million

**Skin - Sun Exposed (Lower leg)**

8.39

**Skin - Not Sun Exposed (Suprapubic)**

8.36

**Thyroid**

8.08

**Minor Salivary Gland**

7.11

**Esophagus - Mucosa**

6.41

### All tissues (54)

Expression in transcripts per million

- Skin - Sun Exposed (Lower leg)8.39
- Skin - Not Sun Exposed (Suprapubic)8.36
- Thyroid8.08
- Minor Salivary Gland7.11
- Esophagus - Mucosa6.41
- Small Intestine - Terminal Ileum5.6
- Pituitary5.55
- Vagina4.64
- Stomach4.34
- Lung4.25
- Kidney - Medulla4.1
- Nerve - Tibial3.87
- Cervix - Endocervix3.54
- Colon - Transverse3.13
- Brain - Cerebellar Hemisphere2.92
- Heart - Atrial Appendage2.9
- Kidney - Cortex2.72
- Breast - Mammary Tissue2.65
- Adipose - Visceral (Omentum)2.41
- Cervix - Ectocervix2.38
- Cells - Cultured fibroblasts2.36
- Brain - Cerebellum2.27
- Testis2.23
- Adrenal Gland2.19
- Brain - Frontal Cortex (BA9)2.12

And 29 more, listed on the interactive page.

## Biological functions

### Cellular components

- GO:0005829  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829)

### Molecular functions

- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)

## Related records

### Trials (4)

- Effect of Sulthiame on EEG in Childhood Epilepsy Syndromes
- [Efficacy, Safety and Tolerability of Sulthiame in Patients With Obstructive Sleep Apnea (OSA)](https://trialight.com/data/trial/efficacy-safety-and-tolerability-of-sulthiame-in-patients-24d07a6b-997f-4748-b549-ef4a765e93d6.md)
- Pharmacokinetics and Tolerability of Sulthiame
- Population Pharmacokinetics of Antiepileptic in Pediatrics

### Drugs (2)

- Ethoxzolamide Carbonic anhydrase inhibitor
- [Sulthiame](https://trialight.com/data/asset/sulthiame-fadcf797-be06-41d8-8b6a-16cfc47603e4.md) Carbonic anhydrase inhibitor

---

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