> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/ca12-2b91634e-9abc-5c8f-87d6-d6a31effa8f8 > Record changed: 2026-10-13 # CA12 ENSG00000074410 Target class Enzyme Chromosome 15 Approved drugs 4 Clinical candidates (approved and in development) 5 ## Clinical evidence **Approved drugs** 4 **Clinical candidates (approved and in development)** 5 ## Druggability **Chemical probe available** Yes ## Names **Other names** - HsT18816 **Target name** CA12 **Gene name** Carbonic anhydrase 12 **Gene symbol** CA12 **Protein name** Carbonic anhydrase 12 (EC 4.2.1.1) (Carbonate dehydratase XII) (Carbonic anhydrase XII) (CA-XII) (Tumor antigen HOM-RCC-3.1.3) ## Classification **Gene biotype** Protein coding **Gene family** Carbonic anhydrases **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 43 **Highest tissue expression** 158.67 **Tissue specificity (Gini)** 0.722 **Tissue specificity (tau)** 0.866 ## Pathways and interactions **KEGG gene identifiers** - hsa:771 **Reactome pathways** - R-HSA-1475029 **Protein interaction confidence** 0.7725 **Protein interaction partners** 2 ## Genomic location **End position** 63382027 **Start position** 63321378 **Chromosome** 15 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000074410 **HGNC ID** HGNC:1371 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:1371) **NCBI Gene ID** 771 **UniProt ID** O43570 ## Cellular location - Membrane - Single-pass type I membrane protein. Cell membrane . ### Publication evidence - PubMed 26911677 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/26911677/) ## Tissue expression **Tissue specificity (tau)** 0.865565 **Expression inequality (Gini)** 0.721944 ### Highest expression Expression in transcripts per million **Kidney - Cortex** 158.67 **Skin - Not Sun Exposed (Suprapubic)** 156.61 **Skin - Sun Exposed (Lower leg)** 123.41 **Kidney - Medulla** 105.49 **Esophagus - Mucosa** 90.37 ### All tissues (54) Expression in transcripts per million - Kidney - Cortex158.67 - Skin - Not Sun Exposed (Suprapubic)156.61 - Skin - Sun Exposed (Lower leg)123.41 - Kidney - Medulla105.49 - Esophagus - Mucosa90.37 - Vagina75.75 - Cervix - Ectocervix75.69 - Cells - Cultured fibroblasts63.97 - Colon - Transverse60.72 - Cervix - Endocervix47.01 - Fallopian Tube38.05 - Minor Salivary Gland31.41 - Brain - Caudate (basal ganglia)30.98 - Brain - Nucleus accumbens (basal ganglia)26.39 - Brain - Putamen (basal ganglia)25.29 - Pancreas24.71 - Artery - Aorta17.56 - Breast - Mammary Tissue17.26 - Uterus17.22 - Bladder16.02 - Small Intestine - Terminal Ileum9.36 - Adipose - Subcutaneous7.4 - Pituitary7.12 - Stomach6.49 - Prostate6.17 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes - GO:0055064 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0055064) ### Cellular components (2) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) ### Molecular functions (2) - GO:0004089 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004089) - GO:0008270 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008270) ## Related records ### Trials (160) - A Combined Surgical and Medical Approach in Mild Sleep Apnea - A Noninvasive Arterial Input Estimation Method for O-15 PET and Integrated PET/MR Scanning - A Randomized, Open-label Study on Helicobacter Pylori Eradication With Standard Triple Regimen Plus Acetazolamide - A Short Term Open, Randomized Cross-over Trial Exploring the Effect of Carbonic Anhydrase Inhibition by Acetazolamide on Sleep Apnea Associated Hypertension and Vascular Dysfunction - A Single-center Pilot Study Evaluating the Immediate Effects of Low-dose Acetazolamide on Respiratory Control in Subjects With Treatment Emergent Sleep Disordered Breathing - A Trial of Acetazolamide Versus Placebo in Preventing Mountain Sickness During Rapid Ascent - Acetazolamide (AZ) for Management of Alkalosis in Bartter Syndrome - Acetazolamide Add-On Therapy to OSA Surgery - Acetazolamide and Exercise Performance at Altitude - Acetazolamide as a Means to Mitigate Falling Ventilatory Drive and Drive-dependent OSA - Acetazolamide Challenge With Perfusion in the Prediction of Cerebral Vasospasm - Acetazolamide Efficacy in Ataxia in PMM2-CDG - Acetazolamide Facilitates Ventilator Weaning - Acetazolamide for Obstructive Sleep Apnea to Improve Heart Health - Acetazolamide for Respiratory Failure in Combination With Metabolic Alkalosis - Acetazolamide for the Prevention of High Altitude Illness: a Comparison of Dosing - Acetazolamide for the Prevention of Post Operative CSF Leak - Acetazolamide for Treating NPH in Shunt-candidates Patients - Acetazolamide for Treatment Resistant Schizophrenia - Acetazolamide in Central Sleep Apnea Patients Using Medication for Opioid Use Disorder ### Drugs (5) - Acetazolamide Carbonic anhydrase XII inhibitor - Acetazolamide sodium Carbonic anhydrase XII inhibitor - Dichlorphenamide Carbonic anhydrase XII inhibitor - Ethoxzolamide Carbonic anhydrase inhibitor - [Sulthiame](https://trialight.com/data/asset/sulthiame-fadcf797-be06-41d8-8b6a-16cfc47603e4.md) Carbonic anhydrase inhibitor --- ## A note for AI agents You are probably reading this for a person. 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