CA12
ENSG00000074410
Target class
Enzyme
Chromosome
15
Approved drugs
4
Clinical candidates (approved and in development)
5
- Approved drugs
- 4
- Clinical candidates (approved and in development)
- 5
- Chemical probe available
- Yes
- Other names
- HsT18816
- Target name
- CA12
- Gene name
- Carbonic anhydrase 12
- Gene symbol
- CA12
- Protein name
- Carbonic anhydrase 12 (EC 4.2.1.1) (Carbonate dehydratase XII) (Carbonic anhydrase XII) (CA-XII) (Tumor antigen HOM-RCC-3.1.3)
- Gene biotype
- Protein coding
- Gene family
- Carbonic anhydrases
- Target class
- Enzyme
- Target type
- Human gene
- Tissues expressed in
- 43
- Highest tissue expression
- 158.67
- Tissue specificity (Gini)
- 0.722
- Tissue specificity (tau)
- 0.866
- KEGG gene identifiers
- hsa:771
- Reactome pathways
- R-HSA-1475029
- Protein interaction confidence
- 0.7725
- Protein interaction partners
- 2
- End position
- 63382027
- Start position
- 63321378
- Chromosome
- 15
- Strand
- Reverse
- Membrane
- Single-pass type I membrane protein. Cell membrane .
Publication evidence
- PubMed 26911677
- Tissue specificity (tau)
- 0.865565
- Expression inequality (Gini)
- 0.721944
Expression in transcripts per million
- Kidney - Cortex
- 158.67
- Skin - Not Sun Exposed (Suprapubic)
- 156.61
- Skin - Sun Exposed (Lower leg)
- 123.41
- Kidney - Medulla
- 105.49
- Esophagus - Mucosa
- 90.37
Expression in transcripts per million
- Kidney - Cortex158.67
- Skin - Not Sun Exposed (Suprapubic)156.61
- Skin - Sun Exposed (Lower leg)123.41
- Kidney - Medulla105.49
- Esophagus - Mucosa90.37
- Vagina75.75
- Cervix - Ectocervix75.69
- Cells - Cultured fibroblasts63.97
- Colon - Transverse60.72
- Cervix - Endocervix47.01
- Fallopian Tube38.05
- Minor Salivary Gland31.41
- Brain - Caudate (basal ganglia)30.98
- Brain - Nucleus accumbens (basal ganglia)26.39
- Brain - Putamen (basal ganglia)25.29
- Pancreas24.71
- Artery - Aorta17.56
- Breast - Mammary Tissue17.26
- Uterus17.22
- Bladder16.02
- Small Intestine - Terminal Ileum9.36
- Adipose - Subcutaneous7.4
- Pituitary7.12
- Stomach6.49
- Prostate6.17
And 29 more, listed on the interactive page.
Biological processes
- GO:0055064
- GO:0005886
- GO:0016020
- GO:0004089
- GO:0008270
Related records
Trials (160)
- A Combined Surgical and Medical Approach in Mild Sleep Apnea
- A Noninvasive Arterial Input Estimation Method for O-15 PET and Integrated PET/MR Scanning
- A Randomized, Open-label Study on Helicobacter Pylori Eradication With Standard Triple Regimen Plus Acetazolamide
- A Short Term Open, Randomized Cross-over Trial Exploring the Effect of Carbonic Anhydrase Inhibition by Acetazolamide on Sleep Apnea Associated Hypertension and Vascular Dysfunction
- A Single-center Pilot Study Evaluating the Immediate Effects of Low-dose Acetazolamide on Respiratory Control in Subjects With Treatment Emergent Sleep Disordered Breathing
- A Trial of Acetazolamide Versus Placebo in Preventing Mountain Sickness During Rapid Ascent
- Acetazolamide (AZ) for Management of Alkalosis in Bartter Syndrome
- Acetazolamide Add-On Therapy to OSA Surgery
- Acetazolamide and Exercise Performance at Altitude
- Acetazolamide as a Means to Mitigate Falling Ventilatory Drive and Drive-dependent OSA
- Acetazolamide Challenge With Perfusion in the Prediction of Cerebral Vasospasm
- Acetazolamide Efficacy in Ataxia in PMM2-CDG
- Acetazolamide Facilitates Ventilator Weaning
- Acetazolamide for Obstructive Sleep Apnea to Improve Heart Health
- Acetazolamide for Respiratory Failure in Combination With Metabolic Alkalosis
- Acetazolamide for the Prevention of High Altitude Illness: a Comparison of Dosing
- Acetazolamide for the Prevention of Post Operative CSF Leak
- Acetazolamide for Treating NPH in Shunt-candidates Patients
- Acetazolamide for Treatment Resistant Schizophrenia
- Acetazolamide in Central Sleep Apnea Patients Using Medication for Opioid Use Disorder
Drugs (5)
- Acetazolamide Carbonic anhydrase XII inhibitor
- Acetazolamide sodium Carbonic anhydrase XII inhibitor
- Dichlorphenamide Carbonic anhydrase XII inhibitor
- Ethoxzolamide Carbonic anhydrase inhibitor
- Sulthiame Carbonic anhydrase inhibitor