> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/ca1-1e40cbcb-6e9b-5ec6-bd31-592c0102d78e > Record changed: 2026-10-13 # CA1 ENSG00000133742 Target class Enzyme Chromosome 8 Approved drugs 6 Clinical candidates (approved and in development) 8 ## Clinical evidence **Approved drugs** 6 **Clinical candidates (approved and in development)** 8 ## Druggability **Chemical probe available** No ## Names **Other names** - Car1 **Target name** CA1 **Gene name** Carbonic anhydrase 1 **Gene symbol** CA1 **Protein name** Carbonic anhydrase 1 (EC 4.2.1.1) (Carbonate dehydratase I) (Carbonic anhydrase B) (CAB) (Carbonic anhydrase I) (CA-I) (Cyanamide hydratase CA1) (EC 4.2.1.69) ## Classification **Gene biotype** Protein coding **Gene family** Carbonic anhydrases **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 4 **Highest tissue expression** 87.47 **Tissue specificity (Gini)** 0.937 **Tissue specificity (tau)** 0.989 ## Pathways and interactions **KEGG gene identifiers** - hsa:759 **Protein interaction confidence** 0.797 **Protein interaction partners** 12 ### Reactome pathways (4) - R-HSA-1237044 - R-HSA-1247673 - R-HSA-1475029 - R-HSA-8950505 ## Genomic location **End position** 85379014 **Start position** 85327608 **Chromosome** 8 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000133742 **HGNC ID** HGNC:1368 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:1368) **NCBI Gene ID** 759 **UniProt ID** P00915 ## Cellular location - Cytoplasm . ## Tissue expression **Tissue specificity (tau)** 0.989066 **Expression inequality (Gini)** 0.936644 ### Highest expression Expression in transcripts per million **Colon - Transverse** 87.47 **Whole Blood** 40.01 **Spleen** 3.99 **Lung** 1 **Colon - Sigmoid** 0.48 ### All tissues (54) Expression in transcripts per million - Colon - Transverse87.47 - Whole Blood40.01 - Spleen3.99 - Lung1 - Colon - Sigmoid0.48 - Liver0.3 - Fallopian Tube0.25 - Small Intestine - Terminal Ileum0.25 - Pituitary0.24 - Cervix - Ectocervix0.19 - Thyroid0.19 - Kidney - Cortex0.19 - Adipose - Visceral (Omentum)0.18 - Vagina0.14 - Brain - Substantia nigra0.13 - Brain - Spinal cord (cervical c-1)0.13 - Kidney - Medulla0.12 - Bladder0.12 - Brain - Cerebellum0.12 - Heart - Atrial Appendage0.11 - Brain - Hypothalamus0.11 - Breast - Mammary Tissue0.11 - Minor Salivary Gland0.1 - Artery - Coronary0.1 - Uterus0.1 And 29 more, listed on the interactive page. ## Biological functions ### Cellular components (2) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) ### Molecular functions (5) - GO:0004064 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004064) - GO:0004089 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004089) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0016836 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016836) - GO:0018820 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0018820) ## Related records ### Trials (182) - A Combined Surgical and Medical Approach in Mild Sleep Apnea - A Noninvasive Arterial Input Estimation Method for O-15 PET and Integrated PET/MR Scanning - A Phase 3 Study of F14 for Management of Pain Following Total Knee Replacement - A Randomized, Open-label Study on Helicobacter Pylori Eradication With Standard Triple Regimen Plus Acetazolamide - A Short Term Open, Randomized Cross-over Trial Exploring the Effect of Carbonic Anhydrase Inhibition by Acetazolamide on Sleep Apnea Associated Hypertension and Vascular Dysfunction - A Single-center Pilot Study Evaluating the Immediate Effects of Low-dose Acetazolamide on Respiratory Control in Subjects With Treatment Emergent Sleep Disordered Breathing - A Trial of Acetazolamide Versus Placebo in Preventing Mountain Sickness During Rapid Ascent - Acamprosate and Methazolamide for Essential Tremor - Acetazolamide (AZ) for Management of Alkalosis in Bartter Syndrome - Acetazolamide Add-On Therapy to OSA Surgery - Acetazolamide and Exercise Performance at Altitude - Acetazolamide as a Means to Mitigate Falling Ventilatory Drive and Drive-dependent OSA - Acetazolamide Challenge With Perfusion in the Prediction of Cerebral Vasospasm - Acetazolamide Efficacy in Ataxia in PMM2-CDG - Acetazolamide Facilitates Ventilator Weaning - Acetazolamide for Obstructive Sleep Apnea to Improve Heart Health - Acetazolamide for Respiratory Failure in Combination With Metabolic Alkalosis - Acetazolamide for the Prevention of High Altitude Illness: a Comparison of Dosing - Acetazolamide for the Prevention of Post Operative CSF Leak - Acetazolamide for Treating NPH in Shunt-candidates Patients ### Drugs (8) - Acetazolamide Carbonic anhydrase I inhibitor - Acetazolamide sodium Carbonic anhydrase I inhibitor - Dichlorphenamide Carbonic anhydrase I inhibitor - Ethoxzolamide Carbonic anhydrase inhibitor - Methazolamide Carbonic anhydrase I inhibitor - Methocarbamol Carbonic anhydrase I inhibitor - Polmacoxib Carbonic anhydrase I inhibitor - [Sulthiame](https://trialight.com/data/asset/sulthiame-fadcf797-be06-41d8-8b6a-16cfc47603e4.md) Carbonic anhydrase inhibitor --- ## A note for AI agents You are probably reading this for a person. 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