> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/c5-8ddb191a-5536-5177-83c7-578f41e4de55 > Record changed: 2026-11-04 # C5 ENSG00000106804 Target class Secreted protein Chromosome 9 Approved drugs 6 Clinical candidates (approved and in development) 12 ## Clinical evidence **Approved drugs** 6 **Clinical candidates (approved and in development)** 12 ## Druggability **Chemical probe available** No ## Names **Target name** C5 **Gene name** Complement C5 **Gene symbol** C5 **Protein name** Complement C5 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4) \[Cleaved into: Complement C5 beta chain; Complement C5 alpha chain; C5a anaphylatoxin; Complement C5b (Complement C5 alpha' chain)\] ### Other names (3) - CPAMD4 - C5a - C5b ## Classification **Gene biotype** Protein coding **Gene family** Receptor ligands|C3 and PZP like, alpha-2-macroglobulin domain containing|Complement system activation components|Membrane Attack complex **Target class** Secreted protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 51 **Highest tissue expression** 121.08 **Tissue specificity (Gini)** 0.554 **Tissue specificity (tau)** 0.966 ## Pathways and interactions **KEGG gene identifiers** - hsa:727 **Protein interaction confidence** 0.830077 **Protein interaction partners** 39 ### Reactome pathways (5) - R-HSA-166665 - R-HSA-174577 - R-HSA-375276 - R-HSA-418594 - R-HSA-977606 ## Genomic location **End position** 121075195 **Start position** 120932987 **Chromosome** 9 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000106804 **HGNC ID** HGNC:1331 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:1331) **NCBI Gene ID** 727 **UniProt ID** P01031 ## Cellular location - Secreted . - SUBCELLULAR LOCATION: \[Complement C5b\]: Secreted . Target cell membrane . Note=Secreted as soluble protein. Inserts into the cell membrane of target cells. . - SUBCELLULAR LOCATION: \[C5a anaphylatoxin\]: Secreted . ### Publication evidence (6) - PubMed 106884 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/106884/) - PubMed 30552328 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/30552328/) - PubMed 30643019 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/30643019/) - PubMed 31061395 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/31061395/) - PubMed 32569291 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/32569291/) - PubMed 690134 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/690134/) ## Tissue expression **Tissue specificity (tau)** 0.96584 **Expression inequality (Gini)** 0.55435 ### Highest expression Expression in transcripts per million **Liver** 121.08 **Nerve - Tibial** 15.4 **Pancreas** 8.39 **Artery - Coronary** 8.34 **Artery - Tibial** 7.71 ### All tissues (54) Expression in transcripts per million - Liver121.08 - Nerve - Tibial15.4 - Pancreas8.39 - Artery - Coronary8.34 - Artery - Tibial7.71 - Artery - Aorta7.47 - Cervix - Endocervix7.38 - Stomach7.06 - Cervix - Ectocervix7.03 - Uterus6.91 - Ovary6.89 - Fallopian Tube6.7 - Pituitary6.54 - Prostate6.41 - Lung6.27 - Esophagus - Gastroesophageal Junction5.37 - Colon - Sigmoid5.22 - Bladder4.97 - Esophagus - Muscularis4.76 - Adipose - Subcutaneous4.75 - Breast - Mammary Tissue4.69 - Cells - Cultured fibroblasts4.58 - Vagina4.4 - Adipose - Visceral (Omentum)4.01 - Skin - Not Sun Exposed (Suprapubic)3.88 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (8) - GO:0006935 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006935) - GO:0006954 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006954) - GO:0007166 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007166) - GO:0007186 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007186) - GO:0010575 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010575) - GO:0010760 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010760) - GO:0032722 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032722) - GO:0160257 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0160257) ### Cellular components (3) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005579 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005579) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) ### Molecular functions (3) - GO:0005102 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005102) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0008009 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008009) ## Related records ### Trials (238) - A Long-Term Safety Study of BCX9930 in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) - A Multicenter, Randomized, Open-Label, Positive Controlled Phase III Study to Evaluate the Efficacy and Safety of VSA012 Injection in Participants With Paroxysmal Nocturnal Hemoglobinuria Who Are Naive to Complement Inhibitor Therapy - [A Multiple Dose Study of AVD-104 for Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration (AMD)](https://trialight.com/data/trial/a-multiple-dose-study-of-avd-104-for-geographic-atrophy-ga-feaa6940-8fb6-45fe-abd6-c16d3d684874.md) - A Phase 2A Study of ALXN1007 in Participants With Newly Diagnosed Acute Lower Gastrointestinal Graft-Versus-Host Disease - A Phase 3 Open-Label Study of Eculizumab in Pediatric Participants With Refractory Generalized Myasthenia Gravis (gMG) - A Phase III Study of NTQ5082 Capsules in the Treatment of Paroxysmal Nocturnal Hemoglobinuria Patients - A Phase III Study to Evaluate the Efficacy and Safety of HSK39297 in Patients With Paroxysmal Nocturnal Hemoglobinuria Who Are Naive to Complement Inhibitor Therapy - A Randomized Controlled Trial of Eculizumab in AQP4 Antibody-positive Participants With NMO (PREVENT Study) - A Safety and Immunogenicity Study in Long-term Treatment of Eculizumab (JSC "GENERIUM", Russian Federation) - A Study Evaluating the Efficacy and Safety of ABP 959 Compared With Eculizumab in Adult Participants With PNH - A Study Evaluating the Efficacy and Safety of Crovalimab Versus Eculizumab in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Not Previously Treated With Complement Inhibitors - A Study Evaluating the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Crovalimab in Adult and Adolescent Participants With Atypical Hemolytic Uremic Syndrome (aHUS) - A Study Evaluating the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Crovalimab in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Not Previously Treated With Complement Inhibition - A Study Evaluating the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Crovalimab in Pediatric Participants With Atypical Hemolytic Uremic Syndrome (aHUS) - A Study Evaluating the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Crovalimab as Adjunct Treatment in Prevention of Vaso-Occlusive Episodes (VOE) in Sickle Cell Disease (SCD) - A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Crovalimab Versus Eculizumab in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Currently Treated With Complement Inhibitors - A Study Evaluating the Safety, Pharmacokinetics, Pharmacodynamics and Efficacy of Crovalimab for the Management of Acute Uncomplicated Vaso-Occlusive Episodes (VOE) in Participants With Sickle Cell Disease (SCD). - A Study in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) to Evaluate How Safe Long-term Treatment With Pozelimab + Cemdisiran Combination Therapy is and How Well it Works - [A Study Investigating Subcutaneously Administered Pozelimab in Combination With Cemdisiran or Cemdisiran Alone in Adult Participants With Geographic Atrophy](https://trialight.com/data/trial/a-study-investigating-subcutaneously-administered-pozelimab-b083d65d-30e8-4381-b771-08f8695e6810.md) - A Study of a Single Dose of ALXN1210 in Healthy Participants ### Drugs (13) - [Avacincaptad pegol sodium](https://trialight.com/data/asset/avacincaptad-pegol-sodium-70032082-2b93-47d0-a0ad-8dc753ae4b2c.md) Complement C5 inhibitor - [Cemdisiran](https://trialight.com/data/asset/cemdisiran-d9f2506d-d99e-4327-8ac8-775201880146.md) Complement C5 mRNA RNAi inhibitor - Crovalimab Complement C5 inhibitor - Eculizumab Complement C5 inhibitor - Nomacopan Complement C5 inhibitor - Olendalizumab Complement C5 inhibitor - Pexelizumab Complement C5 inhibitor - [Pozelimab](https://trialight.com/data/asset/pozelimab-b1dde3e4-bc26-40a5-98bd-c8a34129af59.md) Complement C5 inhibitor - Ravulizumab Complement C5 inhibitor - Tesidolumab Complement C5 binding agent - [Vilobelimab](https://trialight.com/data/asset/vilobelimab-29c7e656-93c5-41f6-9ff0-98e01ff7f32d.md) Complement C5 inhibitor - Zilucoplan Complement C5 inhibitor - Zilucoplan sodium Complement C5 binding agent --- ## A note for AI agents You are probably reading this for a person. 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