> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/btk-0715d96c-6e26-5c6e-a6e0-2a745512051d > Record changed: 2026-10-13 # BTK ENSG00000010671 Target class Kinase Chromosome X Approved drugs 8 Clinical candidates (approved and in development) 23 ## Clinical evidence **Approved drugs** 8 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 23 ## Druggability **Chemical probe available** Yes ## Names **Target name** BTK **Gene name** Bruton tyrosine kinase **Gene symbol** BTK **Protein name** Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase) ### Other names (3) - ATK - XLA - PSCTK1 ### Previous gene symbols (2) - AGMX1 - IMD1 ## Classification **Gene biotype** Protein coding **Gene family** Pleckstrin homology domain containing|SH2 domain containing|Tec family tyrosine kinases **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 34 **Protein localisation evidence grade** Supported **Highest tissue expression** 114 **Tissue specificity (Gini)** 0.741 **Tissue specificity (tau)** 0.967 ## Pathways and interactions **KEGG gene identifiers** - hsa:695 **Protein interaction confidence** 0.8607 **Protein interaction partners** 70 ### Reactome pathways (14) - R-HSA-1236974 - R-HSA-166058 - R-HSA-2029482 - R-HSA-2424491 - R-HSA-2871809 - R-HSA-416476 - R-HSA-416482 - R-HSA-5602498 - R-HSA-5603041 - R-HSA-5663213 - R-HSA-8964315 - R-HSA-9664422 - R-HSA-9679191 - R-HSA-983695 ## Genomic location **End position** 101390796 **Start position** 101349338 **Chromosome** X **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000010671 **HGNC ID** HGNC:1133 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:1133) **NCBI Gene ID** 695 **UniProt ID** Q06187 ## Cellular location - Cytoplasm . Cell membrane - Peripheral membrane protein . Nucleus . Membrane raft . Note=In steady state, BTK is predominantly cytosolic. Following B-cell receptor (BCR) engagement by antigen, translocates to the plasma membrane through its PH domain. Plasma membrane localization is a critical step in the activation of BTK. A fraction of BTK also shuttles between the nucleus and the cytoplasm, and nuclear export is mediated by the nuclear export receptor CRM1\. . - Cytosol - Plasma membrane ### Publication evidence (5) - PubMed 11016936 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/11016936/) - PubMed 25704810 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/25704810/) - PubMed 10196179 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/10196179/) - PubMed 10602036 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/10602036/) - PubMed 19290921 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/19290921/) ## Tissue expression **Tissue specificity (tau)** 0.966665 **Expression inequality (Gini)** 0.741323 ### Highest expression Expression in transcripts per million **Cells - EBV-transformed lymphocytes** 114 **Spleen** 49.73 **Whole Blood** 28.49 **Lung** 17.43 **Small Intestine - Terminal Ileum** 9.89 ### All tissues (54) Expression in transcripts per million - Cells - EBV-transformed lymphocytes114 - Spleen49.73 - Whole Blood28.49 - Lung17.43 - Small Intestine - Terminal Ileum9.89 - Adipose - Subcutaneous6.07 - Nerve - Tibial4.94 - Brain - Spinal cord (cervical c-1)4.68 - Adipose - Visceral (Omentum)4.67 - Artery - Coronary4.08 - Bladder3.94 - Colon - Transverse3.66 - Esophagus - Muscularis3.19 - Artery - Aorta3.13 - Esophagus - Gastroesophageal Junction3.08 - Breast - Mammary Tissue2.95 - Minor Salivary Gland2.93 - Skin - Sun Exposed (Lower leg)2.85 - Prostate2.56 - Cervix - Endocervix2.55 - Skin - Not Sun Exposed (Suprapubic)2.53 - Colon - Sigmoid2.42 - Uterus2.38 - Vagina2.33 - Stomach2.32 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (17) - GO:0002250 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002250) - GO:0002721 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002721) - GO:0002755 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002755) - GO:0002902 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002902) - GO:0007498 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007498) - GO:0018108 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0018108) - GO:0019722 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019722) - GO:0035556 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035556) - GO:0038095 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038095) - GO:0042113 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042113) - GO:0043123 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043123) - GO:0045087 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045087) - GO:0045579 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045579) - GO:0050853 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050853) - GO:0097190 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097190) - GO:0141111 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0141111) - GO:1900227 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1900227) ### Cellular components (5) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0045121 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045121) ### Molecular functions (8) - GO:0004713 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004713) - GO:0004715 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004715) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0005524 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005524) - GO:0005547 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005547) - GO:0016004 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016004) - GO:0042802 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802) - GO:0043274 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043274) ## Off-target safety - regulation of catalytic activity ### Studies - biochemical: NVS\_ENZ\_hBTK, is one of one assay component(s) measured or calculated from the NVS\_ENZ\_hBTK assay. It is designed to make measurements of enzyme activity, a form of enzyme reporter, as detected with fluorescence intensity signals by Fluorescence and electrophoretic mobility shift technology. ### Biological samples - cell-free Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) ## Related records ### Trials (1,490) - 19(T2)28z1xx Chimeric Antigen Receptor (CAR) T Cells in People With B-Cell Cancers - [A 104-Week Study of Ritlecitinib Oral Capsules in Adults With Nonsegmental Vitiligo (Active and Stable) Tranquillo 2](https://trialight.com/data/trial/a-104-week-study-of-ritlecitinib-oral-capsules-in-adults-ff919ca0-6ace-45c1-b983-750c0c3cc811.md) - A 16-Week Study to Learn About the Study Medicine Called Ritlecitinib in Adults With Long Lasting Painful Red Skin Lumps, Known by the Medical Term, Hidradenitis Suppurativa, or HS. - A 2×2 Factorial Randomized Controlled Trial for ERCP - A 5-treatment, Study in Healthy Volunteers to Assess The Safety, Tolerability, and Pharmacokinetics of Four Controlled Release (CR) Pregabalin Tablet Formulations and the Immediate Release (IR) Formulation Administered Fasted - A 52-week Study of Rilzabrutinib Efficacy and Safety Compared to Placebo in Adults Diagnosed With IgG4-related Disease - A 52-Week Study of Ritlecitinib Oral Capsules in Adults and Adolescents With Nonsegmental Vitiligo (Active and Stable) Tranquillo - A 52-Week Study to Learn About the Safety and Effects of Ritlecitinib in Participants With Nonsegmental Vitiligo - A Bioavailability Study of SHR1459 on Healthy Chinese Volunteers - A Clinical Study Evaluating the Safety and Efficacy of ZRMT Regimen in the Treatment of PCNSL - A Clinical Study of iNSC Intervent Cerebral Hemorrhagic Stroke - A Clinical Study on the Efficacy and Safety of Methotrexate (MTX) or Thiotepa (for MTX Intolerance) or Temozolomide (TMZ) Combined With Orelabrutinib and Selinexor in Relapsed/Refractory Primary or Secondary Central Nervous System Lymphoma（SELINA） - A Clinical Study on the Treatment of LACC With Cadonilimab Combined With Chemotherapy Followed by CCRT - A Clinical Trial of Buparlisib and Ibrutinib in Lymphoma - A Clinical Trial of the Orelabrutinib in the Management of Refractory ITP - A Combination of Acalabrutinib With R-CHOP for Patient Diffuse Large B-cell Lymphoma (DLBCL) - A Combination of Acalabrutinib With R-CHOP in Subjects With Previously Untreated Non-GCB DLBCL (ACE-LY-312) - A Combination Study of CAR-T Therapy in r/r B-NHL - A Comparative Bioavailability and Pharmacokinetic Study of TNX-102 2.4 mg and Cyclobenzaprine 5 mg Tablets in Healthy Adults. - A Comparison Between Propofol and Etomidate in Hysteroscopy on Effect of Postoperative Sedation and Cognitive Function in Elderly Patients ### Drugs (24) - Abivertinib Tyrosine-protein kinase BTK inhibitor - Abivertinib maleate Tyrosine-protein kinase BTK inhibitor - Acalabrutinib Tyrosine-protein kinase BTK inhibitor - [Acalabrutinib maleate](https://trialight.com/data/asset/acalabrutinib-maleate-bfe0df80-e311-4f23-9e92-799d6a8c070f.md) Tyrosine-protein kinase BTK inhibitor - BMS-986142 Tyrosine-protein kinase BTK inhibitor - Branebrutinib Tyrosine-protein kinase BTK inhibitor - Edralbrutinib Tyrosine-protein kinase BTK inhibitor - Elsubrutinib Tyrosine-protein kinase BTK inhibitor - Evobrutinib Tyrosine-protein kinase BTK inhibitor - Fenebrutinib Tyrosine-protein kinase BTK inhibitor - [Ibrutinib](https://trialight.com/data/asset/ibrutinib-0b3ac4fd-6e98-4847-a711-2f599e8bb93d.md) Tyrosine-protein kinase BTK inhibitor - MSC-2364447 Tyrosine-protein kinase BTK inhibitor - [Orelabrutinib](https://trialight.com/data/asset/orelabrutinib-f8934fae-2fe2-4ce8-a944-a872e27bfa47.md) Tyrosine-protein kinase BTK inhibitor - Pirtobrutinib Tyrosine-protein kinase BTK inhibitor - [Poseltinib](https://trialight.com/data/asset/poseltinib-2b61b78e-7758-48f6-8b32-cc7f97dd50ed.md) Tyrosine-protein kinase BTK inhibitor - Rilzabrutinib Tyrosine-protein kinase BTK inhibitor - [Ritlecitinib](https://trialight.com/data/asset/ritlecitinib-4c942dd0-fc10-47f2-85c8-213af4721107.md) TEC family kinase inhibitor - Ritlecitinib tosylate TEC family kinase inhibitor - Spebrutinib Tyrosine-protein kinase BTK inhibitor - Spebrutinib besylate Tyrosine-protein kinase BTK inhibitor --- ## A note for AI agents You are probably reading this for a person. 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