> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/brd4-aa5cfcf2-fbc8-55ee-925d-a761ffb4edeb > Record changed: 2026-11-04 # BRD4 ENSG00000141867 Target class Epigenetic regulator Chromosome 19 Approved drugs 0 Clinical candidates (approved and in development) 6 ## Clinical evidence **Approved drugs** 0 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 6 ## Druggability **Chemical probe available** Yes ## Names **Target name** BRD4 **Gene name** Bromodomain containing 4 **Gene symbol** BRD4 **Protein name** Bromodomain-containing protein 4 (Protein HUNK1) ### Other names (5) - HUNKI - MCAP - CAP - HUNK1 - FSHRG4 ## Classification **Gene biotype** Protein coding **Gene family** Bromodomain and extra-terminal domain family|Bromodomain containing **Target class** Epigenetic regulator **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Enhanced **Highest tissue expression** 39.4 **Tissue specificity (Gini)** 0.248 **Tissue specificity (tau)** 0.414 ## Pathways and interactions **KEGG gene identifiers** - hsa:23476 **Protein interaction confidence** 0.835946 **Protein interaction partners** 129 ### Reactome pathways (2) - R-HSA-9679191 - R-HSA-9909649 ## Genomic location **End position** 15332545 **Start position** 15235519 **Chromosome** 19 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000141867 **HGNC ID** HGNC:13575 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:13575) **NCBI Gene ID** 23476 **UniProt ID** O60885 ## Cellular location - Nucleus . Chromosome . Note=Associates with acetylated chromatin (PubMed:16109376, PubMed:21890894). Released from chromatin upon deacetylation of histones that can be triggered by different signals such as activation of the JNK pathway or nocodazole treatment (PubMed:16109376, PubMed:21890894). Preferentially localizes to mitotic chromosomes, while it does not localize to meiotic chromosomes (PubMed:16109376, PubMed:21890894). . - SUBCELLULAR LOCATION: \[Isoform B\]: Chromosome . - Mitotic chromosome - Nucleoplasm ### Publication evidence (4) - PubMed 16109376 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/16109376/) - PubMed 25593309 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/25593309/) - PubMed 21890894 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/21890894/) - PubMed 23728299 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23728299/) ## Tissue expression **Tissue specificity (tau)** 0.414362 **Expression inequality (Gini)** 0.247809 ### Highest expression Expression in transcripts per million **Uterus** 39.4 **Artery - Tibial** 38.87 **Cervix - Endocervix** 38.51 **Ovary** 38.44 **Cervix - Ectocervix** 37.5 ### All tissues (54) Expression in transcripts per million - Uterus39.4 - Artery - Tibial38.87 - Cervix - Endocervix38.51 - Ovary38.44 - Cervix - Ectocervix37.5 - Skin - Sun Exposed (Lower leg)36.09 - Skin - Not Sun Exposed (Suprapubic)34.98 - Testis34.69 - Artery - Aorta34.51 - Nerve - Tibial34.48 - Lung34.43 - Vagina32.98 - Fallopian Tube32.77 - Thyroid32.69 - Artery - Coronary31.26 - Spleen30.85 - Prostate29.83 - Brain - Cerebellum29.66 - Bladder28.62 - Cells - EBV-transformed lymphocytes28.21 - Colon - Sigmoid28.19 - Breast - Mammary Tissue28.1 - Adipose - Subcutaneous27.58 - Brain - Cerebellar Hemisphere26.61 - Esophagus - Gastroesophageal Junction25.4 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (7) - GO:0006357 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006357) - GO:0010971 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010971) - GO:0032968 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032968) - GO:0043123 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043123) - GO:0045893 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045893) - GO:0045944 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045944) - GO:0050727 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050727) ### Cellular components (4) - GO:0000794 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000794) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005654 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654) - GO:0005694 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005694) ### Molecular functions (17) - GO:0000976 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000976) - GO:0002039 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002039) - GO:0003682 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003682) - GO:0003712 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003712) - GO:0003713 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003713) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0008353 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008353) - GO:0019899 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019899) - GO:0099122 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0099122) - GO:0106140 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0106140) - GO:0140008 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140008) - GO:0140011 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140011) - GO:0140012 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140012) - GO:0140046 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140046) - GO:0140055 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140055) - GO:0140072 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140072) - GO:0140119 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140119) ## On-target safety - Gastrointestinal toxicity observed in rats ### Effects - Inhibition/Decrease/Downregulation ### Studies - preclinical ### Biological samples - GI PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) ## Related records ### Trials (375) - A Cross-over Study to Evaluate the Effect of Itraconazole and Rifampicin on the Pharmacokinetics (PK) of GSK525762 in Healthy Female Subjects of Non Child Bearing Potential - A Dose Escalation Study to Investigate the Safety, Pharmacokinetics (PK), Pharmacodynamics (PD) and Clinical Activity of GSK525762 in Subjects With Relapsed, Refractory Hematologic Malignancies - A Dose Escalation Study to Investigate the Safety, Pharmacokinetics (PK), Pharmacodynamics (PD), and Clinical Activity of GSK525762 Plus Trametinib in Subjects With Solid Tumors - A Dose Exploration Study With Birabresib (MK-8628) in Participants With Selected Advanced Solid Tumors (MK-8628-006) - A Dose Exploration Study With Birabresib (MK-8628) in Participants With Selected Hematologic Malignancies (MK-8628-005) - A Dose-escalation Study of the Safety and Tolerability of Orally Administered TG101348 in Patients With Myelofibrosis - A Dose-finding Study of Birabresib (MK-8628) in Participants With Recurrent Glioblastoma Multiforme (MK-8628-002) - A Dose-Finding Study of Birabresib (MK-8628), a Small Molecule Inhibitor of the Bromodomain and Extra-Terminal (BET) Proteins, in Adults With Selected Advanced Solid Tumors (MK-8628-003) - A Dose-finding Study of the Bromodomain (Brd) Inhibitor OTX015/ Birabresib (MK-8628) in Hematologic Malignancies (MK-8628-001) - A Drug-drug Interaction Study to Assess the Effect of Phenytoin and Itraconazole on the Pharmacokinetics of Pelabresib in Healthy Participants - A Drug-drug Interaction Study to Evaluate the Effects of Pelabresib on the Pharmacokinetics of Repaglinide, Midazolam, and Combined Oral Contraceptive in Patients With Advanced Malignancies - A Drug-Food Interaction Study Between Colchicine and Grapefruit Juice - A Long-Term Study of the Effects of Orally Administered SAR302503 in Patients With Myelofibrosis - A Ph2, Colchicine For Inflammatory Carotid Injury And Disease Evolution After Radiotherapy - A Pharmacokinetic Study of Colchicine With an Oral Contraceptive - A Pharmacokinetics and Tolerability Study of Fedratinib in Subjects With Moderate and Severe Hepatic Impairment - A Phase 1 Study Evaluating CPI-0610 in Patients With Previously Treated Multiple Myeloma - A Phase 1 Study Evaluating CPI-0610 in Patients With Progressive Lymphoma - A Phase 1/2 Study of CPI-0610 With and Without Ruxolitinib in Patients With Hematologic and Myeloproliferative Malignancies - A Phase 3 Study of Pelabresib (DAK539) and Ruxolitinib in Myelofibrosis (MF) ### Drugs (16) - Amredobresib - Apabetalone Bromodomain and extra-terminal motif (BET) inhibitor - BI-2536 - Birabresib Bromodomain and extra-terminal motif (BET) inhibitor - [Colchicine](https://trialight.com/data/asset/colchicine-ae804b3e-3263-453f-abb3-ae1e813f2ccf.md) - Ezobresib Bromodomain and extra-terminal motif (BET) inhibitor - Fedratinib - GSK1210151A - GW841819X - LY-294002 - Methylpyrrolidone - Mivebresib - Molibresib Bromodomain and extra-terminal motif (BET) inhibitor - Molibresib besylate Bromodomain and extra-terminal motif (BET) inhibitor - Pelabresib Bromodomain and extra-terminal motif (BET) inhibitor - RO-6870810 Bromodomain and extra-terminal motif (BET) inhibitor --- ## A note for AI agents You are probably reading this for a person. 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