> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/braf-d7fd2910-24ea-5f05-9b83-3cd3e5d8bbdd > Record changed: 2026-10-13 # BRAF ENSG00000157764 Target class Kinase Chromosome 7 Approved drugs 6 Clinical candidates (approved and in development) 17 ## Clinical evidence **Approved drugs** 6 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 17 ## Druggability **Chemical probe available** Yes ## Names **Target name** BRAF **Gene name** B-Raf proto-oncogene, serine/threonine kinase **Gene symbol** BRAF **Protein name** Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) ### Other names (2) - BRAF1 - BRAF-1 ## Classification **Gene biotype** Protein coding **Gene family** Mitogen-activated protein kinase kinase kinases|RAF family **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Supported **Highest tissue expression** 27.58 **Tissue specificity (Gini)** 0.264 **Tissue specificity (tau)** 0.613 ## Pathways and interactions **KEGG gene identifiers** - hsa:673 **Protein interaction confidence** 0.867087 **Protein interaction partners** 92 ### Reactome pathways (16) - R-HSA-1295596 - R-HSA-170968 - R-HSA-170984 - R-HSA-187706 - R-HSA-5673000 - R-HSA-5674135 - R-HSA-5674499 - R-HSA-5675221 - R-HSA-6802946 - R-HSA-6802948 - R-HSA-6802952 - R-HSA-6802955 - R-HSA-9649948 - R-HSA-9656223 - R-HSA-9726840 - R-HSA-9726842 ## Genomic location **End position** 140924976 **Start position** 140719327 **Chromosome** 7 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000157764 **HGNC ID** HGNC:1097 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:1097) **NCBI Gene ID** 673 **UniProt ID** P15056 ## Cellular location - Nucleus . Cytoplasm . Cell membrane . Note=Colocalizes with RGS14 and RAF1 in both the cytoplasm and membranes. . - Cytosol - End piece - Mid piece - Plasma membrane - Principal piece - Vesicles ### Publication evidence - PubMed 19710016 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/19710016/) ## Tissue expression **Tissue specificity (tau)** 0.61331 **Expression inequality (Gini)** 0.264197 ### Highest expression Expression in transcripts per million **Brain - Cerebellar Hemisphere** 27.58 **Brain - Cerebellum** 21.49 **Testis** 20.28 **Thyroid** 17.94 **Uterus** 17.04 ### All tissues (54) Expression in transcripts per million - Brain - Cerebellar Hemisphere27.58 - Brain - Cerebellum21.49 - Testis20.28 - Thyroid17.94 - Uterus17.04 - Ovary16.94 - Fallopian Tube16.7 - Nerve - Tibial16.65 - Cells - EBV-transformed lymphocytes16.32 - Artery - Tibial15.83 - Lung15.59 - Cervix - Endocervix15.54 - Pituitary14.88 - Cervix - Ectocervix14.82 - Skin - Sun Exposed (Lower leg)14.05 - Skin - Not Sun Exposed (Suprapubic)13.69 - Vagina13.57 - Prostate13.49 - Artery - Aorta12.96 - Bladder12.95 - Breast - Mammary Tissue12.92 - Colon - Sigmoid12.66 - Adipose - Subcutaneous12.52 - Brain - Frontal Cortex (BA9)11.98 - Esophagus - Muscularis11.93 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (11) - GO:0000165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000165) - GO:0006468 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006468) - GO:0007173 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007173) - GO:0009887 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009887) - GO:0010628 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010628) - GO:0010828 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010828) - GO:0033138 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0033138) - GO:0043066 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043066) - GO:0070374 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070374) - GO:0071277 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071277) - GO:0090150 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0090150) ### Cellular components (3) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) ### Molecular functions (9) - GO:0004672 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004672) - GO:0004674 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004674) - GO:0004708 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004708) - GO:0005509 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005509) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0031267 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031267) - GO:0042802 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802) - GO:0097110 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097110) - GO:0106310 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0106310) ## On-target safety - heart disease ### Studies - preclinical: Important for the heart and vasculature based on findings in genetically modified or kinase-inhibitor-treated mice. Role of kinase in heart/vasculature: Anti-apoptotic; preserves left ventricular function under stress. Knockout mouse model: left ventricular dysfunction and heart failure in the absence of additional stress; Dominant negative transgenic mouse model: reduced hypertrophy but left ventricular dysfunction due to cell death ### Biological samples - cardiovascular system PubMed 21283106 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/21283106/) ## Related records ### Trials (1,481) - "Dabrafenib and Trametinib in Circulating Free DNA BRAFV600 Mutated Metastatic Melanoma Patients: a Prospective Phase II, Open Label, Multicentre Study - (Bioliquid TAILOR Study - BIOTAILOR)" - "Thymalfasin Immunotherapy Study with Triple Regimen in Advanced MSS/pMMR Colorectal Cancer" - (Neo)Adjuvant BRAF/MEK Inhibition in pN1c Melanoma - (VOYAGER) Study of Avapritinib vs Regorafenib in Patients With Locally Advanced Unresectable or Metastatic GIST - \[18F\]FLT-PET as a Predictive Imaging Biomaker of Treatment Responses to Regorafenib - \[18F\]Fluoroestradiol-PET/CT Companion Imaging Study to the FORESEE Trial - \[18F\]Fluoroestradiol-PET/CT Imaging of Invasive Lobular Carcinoma - \[68 Ga\]-DOTANOC PET/CT in GEP-NETs - \[68Ga\]Ga-FAPI-46 in Staging of Head and Neck Carcinomas - \[68Ga\]Ga-PentixaFor PET/CT in Acute Myocardial Inflammation - 11C-methionine in Diagnostics and Management of Glioblastoma Multiforme Patients (GlioMET) - 17-AAG and Sorafenib in Treating Patients With Unresectable or Metastatic Solid Tumors - 18F-DCFBC PET/CT in Prostate Cancer - 18F-DCFPyL Positron Emission Tomography (PET)/Computed Tomography (CT) in Men With Prostate Cancer - 1st or 2nd Line MBC (Metastatic Breast Cancer) With Previous Avastin (Bevacizumab) Therapy - 4SC-201 (Resminostat) and Sorafenib in Advanced Hepatocellular Carcinoma - 5-Fluorouracil/Leucovorin (5FU/LV) in Combination With Regorafenib in Patients With Metastatic Colorectal Cancer - 68Ga-NODAGA-RGD PET/ CT for Tumoral Neoangiogenesis - 68Ga-NY104 PET/CT Guided Radiation Therapy in CcRCC. - 68Ga-NYM096/177Lu-NYM096 in Metastatic ccRCC ### Drugs (20) - ARQ-736 Serine/threonine-protein kinase B-raf inhibitor - ARQ-736 FREE ACID Serine/threonine-protein kinase B-raf inhibitor - Belvarafenib RAF serine/threonine protein kinase inhibitor - CEP-32496 Serine/threonine-protein kinase B-raf inhibitor - Dabrafenib Serine/threonine-protein kinase B-raf inhibitor - Dabrafenib mesylate Serine/threonine-protein kinase B-raf inhibitor - Encorafenib Serine/threonine-protein kinase B-raf inhibitor - LGX-806 Serine/threonine-protein kinase B-raf inhibitor - Lifirafenib Serine/threonine-protein kinase B-raf inhibitor - LY-3009120 Serine/threonine-protein kinase B-raf inhibitor - Naporafenib B-raf/RAF proto-oncogene serine/threonine-protein kinase inhibitor - Plixorafenib Serine/threonine-protein kinase B-raf inhibitor - RAF-265 Serine/threonine-protein kinase B-raf inhibitor - [Regorafenib](https://trialight.com/data/asset/regorafenib-333c1c36-b89a-41d5-b39e-bcec7346fe94.md) Serine/threonine-protein kinase B-raf inhibitor - RG-7256 Serine/threonine-protein kinase B-raf inhibitor - Sorafenib Serine/threonine-protein kinase B-raf inhibitor - Sorafenib tosylate Serine/threonine-protein kinase B-raf inhibitor - Tovorafenib RAF serine/threonine protein kinase inhibitor - Vemurafenib Serine/threonine-protein kinase B-raf inhibitor - XL-281 Serine/threonine-protein kinase B-raf inhibitor --- ## A note for AI agents You are probably reading this for a person. 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