BRAF

ENSG00000157764
Target class
Kinase
Chromosome
7
Approved drugs
6
Clinical candidates (approved and in development)
17

Approved drugs
6
ClinGen gene-disease validity
Definitive
Clinical candidates (approved and in development)
17

Chemical probe available
Yes

Target name
BRAF
Gene name
B-Raf proto-oncogene, serine/threonine kinase
Gene symbol
BRAF
Protein name
Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1)

  • BRAF1
  • BRAF-1

Gene biotype
Protein coding
Gene family
Mitogen-activated protein kinase kinase kinases|RAF family
Target class
Kinase
Target type
Human gene

Tissues expressed in
54
Protein localisation evidence grade
Supported
Highest tissue expression
27.58
Tissue specificity (Gini)
0.264
Tissue specificity (tau)
0.613

KEGG gene identifiers
  • hsa:673
Protein interaction confidence
0.867087
Protein interaction partners
92

  • R-HSA-1295596
  • R-HSA-170968
  • R-HSA-170984
  • R-HSA-187706
  • R-HSA-5673000
  • R-HSA-5674135
  • R-HSA-5674499
  • R-HSA-5675221
  • R-HSA-6802946
  • R-HSA-6802948
  • R-HSA-6802952
  • R-HSA-6802955
  • R-HSA-9649948
  • R-HSA-9656223
  • R-HSA-9726840
  • R-HSA-9726842

End position
140924976
Start position
140719327
Chromosome
7
Strand
Reverse

Ensembl gene ID
ENSG00000157764
HGNC ID
HGNC:1097
www.genenames.org
NCBI Gene ID
673
UniProt ID
P15056

  • Nucleus . Cytoplasm . Cell membrane . Note=Colocalizes with RGS14 and RAF1 in both the cytoplasm and membranes. .
  • Cytosol
  • End piece
  • Mid piece
  • Plasma membrane
  • Principal piece
  • Vesicles

Publication evidence

Tissue specificity (tau)
0.61331
Expression inequality (Gini)
0.264197

Expression in transcripts per million

Brain - Cerebellar Hemisphere
27.58
Brain - Cerebellum
21.49
Testis
20.28
Thyroid
17.94
Uterus
17.04

Expression in transcripts per million

  • Brain - Cerebellar Hemisphere27.58
  • Brain - Cerebellum21.49
  • Testis20.28
  • Thyroid17.94
  • Uterus17.04
  • Ovary16.94
  • Fallopian Tube16.7
  • Nerve - Tibial16.65
  • Cells - EBV-transformed lymphocytes16.32
  • Artery - Tibial15.83
  • Lung15.59
  • Cervix - Endocervix15.54
  • Pituitary14.88
  • Cervix - Ectocervix14.82
  • Skin - Sun Exposed (Lower leg)14.05
  • Skin - Not Sun Exposed (Suprapubic)13.69
  • Vagina13.57
  • Prostate13.49
  • Artery - Aorta12.96
  • Bladder12.95
  • Breast - Mammary Tissue12.92
  • Colon - Sigmoid12.66
  • Adipose - Subcutaneous12.52
  • Brain - Frontal Cortex (BA9)11.98
  • Esophagus - Muscularis11.93

And 29 more, listed on the interactive page.

  • heart disease

    Studies

    • preclinical: Important for the heart and vasculature based on findings in genetically modified or kinase-inhibitor-treated mice. Role of kinase in heart/vasculature: Anti-apoptotic; preserves left ventricular function under stress. Knockout mouse model: left ventricular dysfunction and heart failure in the absence of additional stress; Dominant negative transgenic mouse model: reduced hypertrophy but left ventricular dysfunction due to cell death

    Biological samples

    • cardiovascular system
    PubMed 21283106
    pubmed.ncbi.nlm.nih.gov

Related records

Trials (1,481)

Drugs (20)