> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/bmx-49d2436f-1bdb-58dd-9637-05eafb2c144e > Record changed: 2026-10-13 # BMX ENSG00000102010 Target class Kinase Chromosome X Approved drugs 2 Clinical candidates (approved and in development) 2 ## Clinical evidence **Approved drugs** 2 **Clinical candidates (approved and in development)** 2 ## Druggability **Chemical probe available** Yes ## Names **Target name** BMX **Gene name** BMX non-receptor tyrosine kinase **Gene symbol** BMX **Protein name** Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38) ### Other names (2) - ETK - PSCTK3 ## Classification **Gene biotype** Protein coding **Gene family** Pleckstrin homology domain containing|SH2 domain containing|Tec family tyrosine kinases **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 31 **Protein localisation evidence grade** Supported **Highest tissue expression** 15.51 **Tissue specificity (Gini)** 0.595 **Tissue specificity (tau)** 0.835 ## Pathways and interactions **KEGG gene identifiers** - hsa:660 **Protein interaction confidence** 0.813833 **Protein interaction partners** 6 ### Reactome pathways (2) - R-HSA-111465 - R-HSA-1660499 ## Genomic location **End position** 15556529 **Start position** 15464246 **Chromosome** X **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000102010 **HGNC ID** HGNC:1079 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:1079) **NCBI Gene ID** 660 **UniProt ID** P51813 ## Cellular location - Cytoplasm . Note=Localizes to the edges of spreading cells when complexed with BCAR1. - Nucleoplasm - Plasma membrane ### Publication evidence - PubMed 12832404 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/12832404/) ## Tissue expression **Tissue specificity (tau)** 0.835128 **Expression inequality (Gini)** 0.594719 ### Highest expression Expression in transcripts per million **Whole Blood** 15.51 **Adipose - Subcutaneous** 12.82 **Breast - Mammary Tissue** 8.24 **Artery - Tibial** 7.94 **Heart - Atrial Appendage** 7.15 ### All tissues (54) Expression in transcripts per million - Whole Blood15.51 - Adipose - Subcutaneous12.82 - Breast - Mammary Tissue8.24 - Artery - Tibial7.94 - Heart - Atrial Appendage7.15 - Fallopian Tube6.72 - Artery - Coronary6.17 - Adipose - Visceral (Omentum)6.16 - Nerve - Tibial6.07 - Uterus5.61 - Artery - Aorta5.58 - Lung5.5 - Small Intestine - Terminal Ileum5.44 - Colon - Transverse4.12 - Cervix - Ectocervix3.89 - Thyroid3.87 - Bladder3.76 - Esophagus - Gastroesophageal Junction3.56 - Spleen3.48 - Colon - Sigmoid3.22 - Esophagus - Muscularis3.15 - Cervix - Endocervix3.15 - Vagina3.02 - Skin - Sun Exposed (Lower leg)2.41 - Skin - Not Sun Exposed (Suprapubic)1.66 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (4) - GO:0006468 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006468) - GO:0006661 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006661) - GO:0007165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165) - GO:0007498 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007498) ### Cellular components (3) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0032587 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032587) ### Molecular functions (3) - GO:0004713 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004713) - GO:0004715 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004715) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (56) - [A 104-Week Study of Ritlecitinib Oral Capsules in Adults With Nonsegmental Vitiligo (Active and Stable) Tranquillo 2](https://trialight.com/data/trial/a-104-week-study-of-ritlecitinib-oral-capsules-in-adults-ff919ca0-6ace-45c1-b983-750c0c3cc811.md) - A 16-Week Study to Learn About the Study Medicine Called Ritlecitinib in Adults With Long Lasting Painful Red Skin Lumps, Known by the Medical Term, Hidradenitis Suppurativa, or HS. - A 52-Week Study of Ritlecitinib Oral Capsules in Adults and Adolescents With Nonsegmental Vitiligo (Active and Stable) Tranquillo - A 52-Week Study to Learn About the Safety and Effects of Ritlecitinib in Participants With Nonsegmental Vitiligo - A DRUG-DRUG INTERACTION STUDY BETWEEN PF-06650833 AND PF-06651600 FOLLOWING MULTIPLE DOSES IN HEALTHY PARTICIPANTS - A Long-Term Study to Learn About The Study Medicine Called Ritlecitinib in Children With Severe Alopecia Areata. - A Phase 2b Study To Evaluate The Efficacy And Safety Profile Of PF-06651600 And PF-06700841 In Active Non-segmental Vitiligo Subjects - A Renal Impairment Study for PF-06651600 - A Single Dose Study To Test Two Pediatric Forms Of Ritlecitinib Compared With Adult Ritlecitinib In Healthy Adults - A Study in Young People and Adults to Learn About the Medicine Ritlecitinib for Treatment of Patchy Hair Loss, Known by the Medical Term as Moderate Alopecia Areata - [A Study of 2 Doses of Ritlecitinib in People 12 Years of Age and Older With Alopecia Areata](https://trialight.com/data/trial/a-study-of-2-doses-of-ritlecitinib-in-people-12-years-of-age-d5004d40-93b5-4a61-97a0-68091c6fb464.md) - A Study of PF-06651600 Effect on Rosuvastatin Pharmacokinetics in Healthy Participants - A Study to Assess Two Forms of The Study Medicine (Ritlecitinib) in Healthy Adult Participants - A STUDY TO ESTIMATE THE EFFECT OF PF-06651600 ON THE PHARMACOKINETICS (PK) OF ORAL CONTRACEPTIVE (OC) - A STUDY TO EVALUATE THE EFFECT OF PF-06651600 ON PHARMACOKINETICS OF SINGLE DOSE SUMATRIPTAN IN HEALTHY PARTICIPANTS. - A Study to Evaluate the Pharmacokinetics, Safety and Tolerability of PF-06651600 in Subjects With Hepatic Impairment and Healthy Volunteers - A Study to Learn About How Different Forms of the Study Medicine Called Ritlecitinib Pass the Intestines of Healthy Male Adults When Taken With or Without Food - A Study to Learn About Litfulo Capsule in People With Severe Alopecia Areata in Routine Clinical Practice. - A Study to Learn About Medicine Called Ritlecitinib in Children Aged Between 6 to 12 Years With Severe Alopecia Areata - A Study to Learn About Ritlecitinib for the Potential Treatment of Chronic Spontaneous Urticaria in Adults. ### Drugs (2) - [Ritlecitinib](https://trialight.com/data/asset/ritlecitinib-4c942dd0-fc10-47f2-85c8-213af4721107.md) TEC family kinase inhibitor - Ritlecitinib tosylate TEC family kinase inhibitor --- ## A note for AI agents You are probably reading this for a person. 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