> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/bmpr2-d56dfb46-af8b-5869-a4df-596a45425581 > Record changed: 2026-11-04 # BMPR2 ENSG00000204217 Target class Kinase Chromosome 2 Approved drugs 2 Clinical candidates (approved and in development) 2 ## Clinical evidence **Approved drugs** 2 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 2 ## Druggability **Chemical probe available** Yes ## Names **Target name** BMPR2 **Gene name** Bone morphogenetic protein receptor type 2 **Gene symbol** BMPR2 **Previous gene symbols** - PPH1 **Protein name** Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) ### Other names (4) - BRK-3 - T-ALK - BMPR3 - BMPR-II ## Classification **Gene biotype** Protein coding **Gene family** Type 2 receptor serine/threonine kinases **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Supported **Highest tissue expression** 45.11 **Tissue specificity (Gini)** 0.284 **Tissue specificity (tau)** 0.646 ## Pathways and interactions **KEGG gene identifiers** - hsa:659 **Reactome pathways** - R-HSA-201451 **Protein interaction confidence** 0.905887 **Protein interaction partners** 53 ## Genomic location **End position** 202567751 **Start position** 202376327 **Chromosome** 2 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000204217 **HGNC ID** HGNC:1078 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:1078) **NCBI Gene ID** 659 **UniProt ID** Q13873 ## Cellular location - Cell membrane - Single-pass type I membrane protein. - Nucleoplasm - Plasma membrane ### Publication evidence - PubMed 25187962 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/25187962/) ## Tissue expression **Tissue specificity (tau)** 0.645897 **Expression inequality (Gini)** 0.283905 ### Highest expression Expression in transcripts per million **Lung** 45.11 **Artery - Aorta** 35.28 **Artery - Coronary** 33.87 **Artery - Tibial** 33.03 **Uterus** 29.4 ### All tissues (54) Expression in transcripts per million - Lung45.11 - Artery - Aorta35.28 - Artery - Coronary33.87 - Artery - Tibial33.03 - Uterus29.4 - Cervix - Endocervix28.74 - Cervix - Ectocervix26.66 - Adipose - Subcutaneous25.68 - Adipose - Visceral (Omentum)23.01 - Nerve - Tibial22.63 - Fallopian Tube22.47 - Bladder22.01 - Adrenal Gland21.88 - Cells - Cultured fibroblasts21.8 - Thyroid21.5 - Breast - Mammary Tissue21.19 - Colon - Sigmoid20.34 - Esophagus - Muscularis19.54 - Vagina19.04 - Ovary19.02 - Esophagus - Gastroesophageal Junction18.9 - Brain - Frontal Cortex (BA9)18.48 - Prostate17.52 - Brain - Cerebellar Hemisphere16.54 - Skin - Sun Exposed (Lower leg)14.78 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (22) - GO:0001649 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001649) - GO:0001935 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001935) - GO:0002063 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002063) - GO:0003085 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003085) - GO:0007178 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007178) - GO:0009267 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009267) - GO:0010628 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010628) - GO:0010634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010634) - GO:0014916 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0014916) - GO:0030154 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030154) - GO:0030308 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030308) - GO:0030501 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030501) - GO:0030509 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030509) - GO:0042127 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042127) - GO:0045669 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045669) - GO:0045944 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045944) - GO:0048662 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048662) - GO:0060391 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060391) - GO:0060426 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060426) - GO:0071773 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071773) - GO:0072577 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0072577) - GO:1902731 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1902731) ### Cellular components (4) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0005901 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005901) - GO:0005912 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005912) ### Molecular functions (5) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0016362 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016362) - GO:0036122 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0036122) - GO:0045296 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045296) - GO:1990782 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1990782) ## Related records ### Trials (116) - A 44-week Monocentric Open Study Assessing the Efficacy and Safety of Deucravacitinib in Adults With Inflammatory Genodermatoses - A Clinical Study to Evaluate the Efficacy and Safety of D-2570 in the Treatment of Moderate to Severe Plaque Psoriasis - A Clinical Trial of TQH3906 Capsules in Adult Patients With Moderate to Severe Plaque Psoriasis - A Observational Study to Evaluate Deucravacitinib in Patients With Moderate Plaque Psoriasis in China - A Phase 2/3 Multicenter, Controlled Trial Of rhBMP-2/CPM In Tibial Fractures - A Real-world Observational Study to Compare Effectiveness of Deucravacitinib Vs Apremilast in Adults With Plaque Psoriasis - A Real-world Study of Deucravacitinib in the Treatment of Moderate to Severe Plaque Psoriasis With Eczematous Features - A Real-world Study to Evaluate the Effectiveness of Deucravacitinib in Adults With Plaque Psoriasis in France (RePhlect) - A Study Comparing the Effects of Famotidine Pretreatment and of Food on the Relative Bioavailability of BMS-986165 in Healthy Volunteers - A Study Comparing the Risk of Serious Infections and Malignancies With Deucravacitinib or Biologics in Japanese Patients With Psoriasis - A Study Comparing Zasocitinib (TAK-279) With Deucravacitinib in Adults With Plaque Psoriasis - A Study Evaluating Deucravacitinib Concentrations in the Breast Milk and Plasma of Healthy Lactating Female Participants - A Study of BMS986365 in Combination With Degarelix in People With Prostate Cancer - A Study of Deucravacitinib to Treat LPP and FFA - A Study of JNJ-77242113 for the Treatment of Participants With Moderate to Severe Plaque Psoriasis - A Study of JNJ-77242113 for the Treatment of Participants With Moderate to Severe Plaque Psoriasis (ICONIC-ADVANCE 2) - A Study of rhBMP-2/CPM in Closed Fractures of the Humerus - A Study of the Comparative Effectiveness of Deucravacitinib in Adults With Plaque Psoriasis in Japan (RePhlect) - A Study of the Safety, Efficacy, and Biomarker Response of BMS-986165 in Participants With Moderate to Severe Ulcerative Colitis - A Study on the Safety of Deucravacitinib Exposure in Pregnant Women and Their Offspring ### Drugs (3) - [Deucravacitinib](https://trialight.com/data/asset/deucravacitinib-3033fa9d-d652-4397-81c1-5e76480167af.md) - Dibotermin alfa Bone morphogenetic protein receptor type-2 agonist - Eptotermin alfa Bone morphogenetic protein receptor type-2 agonist --- ## A note for AI agents You are probably reading this for a person. 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