> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/blk-b1744120-8ac6-54b2-8fb8-287fe1884cc1 > Record changed: 2026-11-04 # BLK ENSG00000136573 Target class Kinase Chromosome 8 Approved drugs 1 Clinical candidates (approved and in development) 5 ## Clinical evidence **Approved drugs** 1 **ClinGen gene-disease validity** Refuted **Clinical candidates (approved and in development)** 5 ## Druggability **Chemical probe available** Yes ## Names **Other names** - MGC10442 **Target name** BLK **Gene name** BLK proto-oncogene, Src family tyrosine kinase **Gene symbol** BLK **Protein name** Tyrosine-protein kinase Blk (EC 2.7.10.2) (B lymphocyte kinase) (p55-Blk) ## Classification **Gene biotype** Protein coding **Gene family** SH2 domain containing|Src family tyrosine kinases **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 6 **Protein localisation evidence grade** Uncertain **Highest tissue expression** 103.76 **Tissue specificity (Gini)** 0.933 **Tissue specificity (tau)** 0.977 ## Pathways and interactions **KEGG gene identifiers** - hsa:640 **Protein interaction confidence** 0.807211 **Protein interaction partners** 19 ### Reactome pathways (2) - R-HSA-8939245 - R-HSA-983695 ## Genomic location **End position** 11564599 **Start position** 11486894 **Chromosome** 8 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000136573 **HGNC ID** HGNC:1057 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:1057) **NCBI Gene ID** 640 **UniProt ID** P51451 ## Cellular location - Cell membrane - Lipid-anchor . Note=Present and active in lipid rafts. Membrane location is required for the phosphorylation of CD79A and CD79B (By similarity). . ## Tissue expression **Tissue specificity (tau)** 0.977215 **Expression inequality (Gini)** 0.933158 ### Highest expression Expression in transcripts per million **Cells - EBV-transformed lymphocytes** 103.76 **Spleen** 82.08 **Small Intestine - Terminal Ileum** 25.48 **Whole Blood** 6.58 **Lung** 1.44 ### All tissues (54) Expression in transcripts per million - Cells - EBV-transformed lymphocytes103.76 - Spleen82.08 - Small Intestine - Terminal Ileum25.48 - Whole Blood6.58 - Lung1.44 - Colon - Transverse1.25 - Stomach0.72 - Esophagus - Mucosa0.72 - Minor Salivary Gland0.63 - Fallopian Tube0.55 - Liver0.54 - Kidney - Cortex0.49 - Thyroid0.45 - Cells - Cultured fibroblasts0.45 - Testis0.4 - Kidney - Medulla0.33 - Adipose - Visceral (Omentum)0.29 - Prostate0.26 - Breast - Mammary Tissue0.22 - Adipose - Subcutaneous0.18 - Bladder0.17 - Vagina0.17 - Cervix - Endocervix0.15 - Artery - Coronary0.15 - Adrenal Gland0.14 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (4) - GO:0018108 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0018108) - GO:0032024 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032024) - GO:0035556 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035556) - GO:0050853 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050853) ### Cellular components - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) ### Molecular functions (3) - GO:0004713 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004713) - GO:0004715 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004715) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (878) - A Bioequivalence Study of Dasatinib Tablet - A Clinical Study of Nemtabrutinib in Japanese Participants With Hematological Malignancies (MK-1026-002) - A Clinical Trial Evaluating the Efficacy and Safety of Dasatinib in Refractory Metastatic GIST - A Clinical Trial of Buparlisib and Ibrutinib in Lymphoma - A Clinical Trial of Nemtabrutinib in Participants With Severe Kidney Disease (MK-1026-027) - A Combination of Acalabrutinib With R-CHOP for Patient Diffuse Large B-cell Lymphoma (DLBCL) - A Combination of Acalabrutinib With R-CHOP in Subjects With Previously Untreated Non-GCB DLBCL (ACE-LY-312) - A Comparison of Three Chemotherapy Regimens for the Treatment of Patients With Newly Diagnosed Mantle Cell Lymphoma - A Crossover Study to Evaluate the Bioavailability of Ibrutinib Suspension and Sprinkle Formulations Compared to Capsules in Healthy Adults - A Dose Escalation and Expansion Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7283420. - A Drug Interaction Study to Assess the Effect of Omeprazole on the Pharmacokinetics of Ibrutinib in Healthy Adults - A Long-term Extension Study of PCI-32765 (Ibrutinib) - A Multi-Center Study of Ibrutinib in Combination With MEDI4736 in Subjects With Relapsed or Refractory Lymphomas - A Multi-Center Study of Ibrutinib in Combination With MEDI4736 in Subjects With Relapsed or Refractory Solid Tumors - A Multi-Center Study of Ibrutinib in Combination With Obinutuzumab Versus Chlorambucil in Combination With Obinutuzumab in Patients With Treatment naïve Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL) - A Multicenter Phase 2 Study of Ibrutinib in Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL) With 17p Deletion - A Pharmacokinetic Study in Healthy Participants to Assess the Pharmacokinetics and Safety of a Supratherapeutic Dose of PCI-32765 (Ibrutinib) Capsule and Solution Formulations Administered With Food - A Phase 1 Safety Study of TG100801 Eye Drops in Healthy Volunteers - A Phase 1 Study of Acalabrutinib in Japanese Adult Patients With Advanced B-cell Malignancies - A Phase 1 Study of MKC-1 in Patients With Refractory Hematologic Malignancies ### Drugs (14) - [Acalabrutinib](https://trialight.com/data/asset/acalabrutinib-17f298f9-e056-45ab-95dc-9a5b0f25c869.md) - CEP-11981 - Dasatinib - Dasatinib anhydrous SRC inhibitor - Dasatinib laurylsulfate SRC inhibitor - ENMD-981693 SRC inhibitor - [Ibrutinib](https://trialight.com/data/asset/ibrutinib-0b3ac4fd-6e98-4847-a711-2f599e8bb93d.md) - Ilorasertib SRC inhibitor - JNJ-64264681 - [Nemtabrutinib](https://trialight.com/data/asset/nemtabrutinib-70bd6eb4-bcf5-4265-a8f7-fbcdab7b9e59.md) - TG100-801 SRC inhibitor - Tirabrutinib - Tirabrutinib hydrochloride - XL-228 SRC inhibitor --- ## A note for AI agents You are probably reading this for a person. 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