> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/bcr-00dc8fce-d299-5199-bf1d-6a96be43275d > Record changed: 2026-10-13 # BCR ENSG00000186716 Target class Other cytosolic protein Chromosome 22 Approved drugs 7 Clinical candidates (approved and in development) 10 ## Clinical evidence **Approved drugs** 7 **Clinical candidates (approved and in development)** 10 ## Druggability **Chemical probe available** Yes ## Names **Target name** BCR **Gene name** BCR activator of RhoGEF and GTPase **Gene symbol** BCR **Protein name** Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-26) ### Other names (4) - D22S662 - CML - PHL - ALL ### Previous gene symbols (2) - D22S11 - BCR1 ## Classification **Gene biotype** Protein coding **Gene family** Pleckstrin homology domain containing|Dbl family Rho GEFs|C2 domain containing|My-T-BRC complex **Target class** Other cytosolic protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Approved **Highest tissue expression** 46.94 **Tissue specificity (Gini)** 0.253 **Tissue specificity (tau)** 0.589 ## Pathways and interactions **KEGG gene identifiers** - hsa:613 **Protein interaction confidence** 0.846455 **Protein interaction partners** 22 ### Reactome pathways (9) - R-HSA-1839117 - R-HSA-5655302 - R-HSA-8980692 - R-HSA-9013026 - R-HSA-9013106 - R-HSA-9013148 - R-HSA-9013149 - R-HSA-9013404 - R-HSA-9013423 ## Genomic location **End position** 23318037 **Start position** 23179704 **Chromosome** 22 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000186716 **HGNC ID** HGNC:1014 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:1014) **NCBI Gene ID** 613 **UniProt ID** P11274 ## Cellular location - Postsynaptic density . Cell projection, dendritic spine . Cell projection, axon . Synapse . - Cytosol - Nucleoplasm - Plasma membrane ## Tissue expression **Tissue specificity (tau)** 0.58874 **Expression inequality (Gini)** 0.253316 ### Highest expression Expression in transcripts per million **Brain - Nucleus accumbens (basal ganglia)** 46.94 **Brain - Caudate (basal ganglia)** 42.9 **Nerve - Tibial** 35.06 **Brain - Putamen (basal ganglia)** 33.78 **Pituitary** 31.78 ### All tissues (54) Expression in transcripts per million - Brain - Nucleus accumbens (basal ganglia)46.94 - Brain - Caudate (basal ganglia)42.9 - Nerve - Tibial35.06 - Brain - Putamen (basal ganglia)33.78 - Pituitary31.78 - Thyroid31.52 - Brain - Cortex29.27 - Artery - Tibial28.94 - Artery - Aorta27.65 - Brain - Frontal Cortex (BA9)27.35 - Lung26.97 - Brain - Anterior cingulate cortex (BA24)26.9 - Skin - Sun Exposed (Lower leg)26.58 - Brain - Cerebellum24.74 - Adipose - Subcutaneous23.88 - Esophagus - Mucosa23.6 - Artery - Coronary23.39 - Skin - Not Sun Exposed (Suprapubic)22.84 - Brain - Amygdala22.55 - Breast - Mammary Tissue22.03 - Adipose - Visceral (Omentum)21.71 - Brain - Cerebellar Hemisphere21.4 - Fallopian Tube21.34 - Kidney - Medulla20.72 - Brain - Hippocampus20.53 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (8) - GO:0006468 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006468) - GO:0007165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165) - GO:0007264 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007264) - GO:0030216 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030216) - GO:0035023 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035023) - GO:0048041 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048041) - GO:0051056 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051056) - GO:0090630 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0090630) ### Cellular components (4) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) - GO:0032991 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032991) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) ### Molecular functions (6) - GO:0004674 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004674) - GO:0004713 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004713) - GO:0005085 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005085) - GO:0005096 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005096) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0106310 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0106310) ## Related records ### Trials (1,122) - 2nd or 3rd TKI-stop After 2 Years Nilotinib Pre-treatment in CML-patients - 5 Years of Adjuvant Imatinib in Patients With Gastrointestinal Stromal Tumor With a High Risk - A 3-cohort Randomized Study Evaluating the Role of New Immunotherapeutic Agents and of Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) in Frontline Therapy of Adults With Acute Lymphoblastic Leukemia - A Bioavailability Study of Nilotinib in Healthy, Adult, Human Subjects Under Fasted Conditions. - A Bioequivalence Study of Dasatinib Tablet - A Clinical Trial Evaluating the Efficacy and Safety of Dasatinib in Refractory Metastatic GIST - A Clinical Trial of the Safety, Pharmacokinetics and Hematologic Effects of Imatinib on Myelopoiesis in Adults When Given With and Without Isoniazid and Rifabutin - A Clinical Trial to Compare the Pharmacokinetics of Imatinib Mesylate Tablet 400mg (1 Tablet) and Glivec Film-coated Tablet 100mg (4 Tablets)(Phase I) - A Clinical Trial to Evaluate the Effect of Nilotinib on the PK/PD of Meformin - A Dose Calibration Study Comparing IkT-001Pro to Imatinib Mesylate 400mg - A Dose Escalation and Expansion Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7283420. - A Dose-finding Study of a Combination of Imatinib and BKM120 in the Treatment of 3rd Line GIST Patients - A Drug Interaction Study Between Bosutinib And Aprepitant In Healthy Volunteers - A Global Imatinib and Nilotinib Pregnancy Exposure Registry - A Multicenter Phase 3, Open-Label Study of Bosutinib Versus Imatinib in Adult Patients With Newly Diagnosed Chronic Phase Chronic Myelogenous Leukemia - A Pharmacokinetic (PK) Study of Nilotinib in Pediatric Patients With Philadelphia Chromosome-positive (Ph+) Chronic Myelogenous Leukemia (CML) or Acute Lymphoblastic Leukemia (ALL) - A Phase 1B Study to Investigate the Safety and Preliminary Efficacy for the Combination of Dasatinib Plus Nivolumab in Patients With Chronic Myeloid Leukemia - A Phase 2 Trial of Ponatinib in Participants With Metastatic and/or Unresectable Gastrointestinal Stromal Tumor - A Phase 3 Study for the Efficacy and Safety of Radotinib in CP-CML Patients With Failure or Intolerance to Previous TKIs - A Phase I Dose Escalation Combination Study in Patients With Chronic Myelogenous Leukemia (CML) and Philadelphia Chromosome-Positive (Ph+) Acute Lymphoblastic Leukemia (ALL)(0457-009)(TERMINATED) ### Drugs (15) - Asciminib Bcr/Abl fusion protein inhibitor - Asciminib hydrochloride Bcr/Abl fusion protein inhibitor - Bosutinib Bcr/Abl fusion protein inhibitor - Bosutinib monohydrate Bcr/Abl fusion protein inhibitor - Dasatinib Bcr/Abl fusion protein inhibitor - Dasatinib anhydrous Bcr/Abl fusion protein inhibitor - Imatinib Bcr/Abl fusion protein inhibitor - [Imatinib mesylate](https://trialight.com/data/asset/imatinib-mesylate-228c51e4-aef9-4351-8581-568722f6cb78.md) Bcr/Abl fusion protein inhibitor - [Nilotinib](https://trialight.com/data/asset/nilotinib-d65cd4c2-39a0-42fd-a05f-8b1e12926bb2.md) Bcr/Abl fusion protein inhibitor - Nilotinib hydrochloride monohydrate Bcr/Abl fusion protein inhibitor - Olverembatinib Bcr/Abl fusion protein inhibitor - Ponatinib Bcr/Abl fusion protein inhibitor - Ponatinib hydrochloride Bcr/Abl fusion protein inhibitor - Radotinib Bcr/Abl fusion protein inhibitor - Vodobatinib Bcr/Abl fusion protein inhibitor --- ## A note for AI agents You are probably reading this for a person. 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