> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/bcl2l2-pabpn1-2150cdc8-8330-5cb0-b740-f5b648a1b94d > Record changed: 2026-11-04 # BCL2L2-PABPN1 ENSG00000258643 Target class Other cytosolic protein Chromosome 14 Approved drugs 0 Clinical candidates (approved and in development) 2 ## Clinical evidence **Approved drugs** 0 **Clinical candidates (approved and in development)** 2 ## Druggability **Chemical probe available** No ## Names **Target name** BCL2L2-PABPN1 **Gene name** BCL2L2-PABPN1 readthrough **Gene symbol** BCL2L2-PABPN1 **Protein name** Bcl-2-like protein 2 (Bcl2-L-2) (Apoptosis regulator Bcl-W) ## Classification **Gene biotype** Protein coding **Target class** Other cytosolic protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 47 **Protein localisation evidence grade** Uncertain **Highest tissue expression** 27.04 **Tissue specificity (Gini)** 0.425 **Tissue specificity (tau)** 0.857 ## Pathways and interactions **KEGG gene identifiers** - hsa:599 **Protein interaction confidence** 0.9535 **Protein interaction partners** 2 ## Genomic location **End position** 23326175 **Start position** 23306833 **Chromosome** 14 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000258643 **HGNC ID** HGNC:42959 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:42959) **NCBI Gene ID** 100529063 **UniProt ID** Q92843 ## Cellular location - Mitochondrion membrane - Peripheral membrane protein . Note=Loosely associated with the mitochondrial membrane in healthy cells. During apoptosis, tightly bound to the membrane. ### Publication evidence (2) - PubMed 11423909 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/11423909/) - PubMed 12952938 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/12952938/) ## Tissue expression **Tissue specificity (tau)** 0.856725 **Expression inequality (Gini)** 0.425064 ### Highest expression Expression in transcripts per million **Testis** 27.04 **Cells - Cultured fibroblasts** 14.96 **Skin - Not Sun Exposed (Suprapubic)** 9.18 **Skin - Sun Exposed (Lower leg)** 9.06 **Adrenal Gland** 8.59 ### All tissues (54) Expression in transcripts per million - Testis27.04 - Cells - Cultured fibroblasts14.96 - Skin - Not Sun Exposed (Suprapubic)9.18 - Skin - Sun Exposed (Lower leg)9.06 - Adrenal Gland8.59 - Stomach7.35 - Esophagus - Mucosa7.26 - Fallopian Tube7.05 - Small Intestine - Terminal Ileum6.64 - Prostate6.07 - Minor Salivary Gland5.96 - Pituitary5.85 - Thyroid5.71 - Colon - Transverse5.33 - Vagina5.13 - Adipose - Subcutaneous5.13 - Nerve - Tibial4.77 - Adipose - Visceral (Omentum)4.65 - Lung4.64 - Cervix - Ectocervix4.64 - Breast - Mammary Tissue4.51 - Bladder4.48 - Ovary4.23 - Esophagus - Gastroesophageal Junction3.79 - Esophagus - Muscularis3.59 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (3) - GO:0007283 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007283) - GO:0042981 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042981) - GO:0043066 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043066) ### Cellular components (2) - GO:0005739 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005739) - GO:0097136 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097136) ### Molecular functions (3) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0042802 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802) - GO:0097718 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097718) ## Related records ### Trials (756) - 8-Chloroadenosine in Combination With Venetoclax for the Treatment of Patients With Relapsed/Refractory Acute Myeloid Leukemia - A Clinical Trial to Learn About the Study Medicine Called Maplirpacept (PF-07901801), Alone and When Used in Combination With Other Medicines to Treat Participants With Advanced Hematological Malignancies, Including Lymphoma, Leukemia and Multiple Myeloma - A Dose-Finding and Efficacy Study of Venetoclax, CC-486, and Obinutuzumab in Follicular Lymphoma - A Multi-phase Study of ASTX030 (Azacitidine and Cedazuridine) in Myeloid Neoplasm Alone or in Combination With Venetoclax in AML (AZTOUND Study) - A Multi-Site Break Through Cancer Trial: Phase II Study Investigating Dual Inhibition of BCL2 and Menin in AML MRD Using the Combination of Venetoclax and Revumenib - A Multi-Site Break Through Cancer Trial: Targeting Measurable Residual Disease in Patients With Acute Myeloid Leukemia: A Phase 1/2 Study of Tagraxofusp, Azacitidine, and Venetoclax - A Multicenter Trial Evaluating Efficacy and Safety of A Reduced Venetoclax Exposure To Seven Days Versus Standard Continuous Venetoclax Exposure Combined With Azacitidine in Treatment Naïve Subjects With Acute Myeloid Leukemia Who Are Ineligible for Intensive Induction - a New Treatment of Newly Diagnosed IDH1 Mutation Acute Myeloid Leukemia - A Pharmacokinetic Study to Access How the Body Absorbs and Removes ABT-199 in Adults With Non-Hodgkin's Lymphoma - A Phase 1 Study Evaluating the Safety and Pharmacokinetics of ABT-199 in Subjects With Relapsed or Refractory Chronic Lymphocytic Leukemia and Non-Hodgkin Lymphoma - A Phase 1 Study of AOH1996 in Patients With Relapsed/Refractory Acute Myeloid Leukemia - A Phase 1 Study With LYT-200 in Patients With Relapsed/Refractory Acute Myeloid Leukemia (AML), or With Relapsed/Refractory, High-risk Myelodysplastic Syndrome (MDS) - [A Phase 1/2 Study of Enzomenib (DSP-5336) in Patients With Acute Leukemia (Horizen-1)](https://trialight.com/data/trial/a-phase-1-2-study-of-enzomenib-dsp-5336-in-patients-with-0e6145c8-1f49-44ed-a3c6-01e969666e64.md) - A Phase 1/2a Study of ABT-263 in Subjects With Small Cell Lung Cancer (SCLC) or Other Non-Hematological Malignancies - A Phase 1b Master Trial to Investigate CPX-351 in Subjects With Previously Untreated Acute Myeloid Leukemia - A Phase 1b Study Evaluating the Safety and Tolerability of ABT-199 in Combination With Rituximab in Subjects With Relapsed Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma - A Phase 1b Study of CLN-049 in Combination With Azacitidine and Venetoclax in AML Patients - A Phase 1b-2 Trial to Assess Venetoclax and Navitoclax Consolidation and Post-transplant Maintenance in High-risk Patients With T-ALL - A Phase 1B/2A Trial of NADUNOLIMAB in Combination With Azacitidine (With/Without Venetoclax) in Patients With Myelodysplastic Syndrome (MDS) and Acute Myelogenous Leukemia (AML) - A Phase 2 Open-Label Study of the Efficacy and Safety of ABT-199 (GDC-0199) in Chronic Lymphocytic Leukemia (CLL) Subjects With Relapse or Refractory to B-Cell Receptor Signaling Pathway Inhibitor Therapy ### Drugs (5) - Navitoclax Apoptosis regulator Bcl-W inhibitor - Navitoclax dihydrochloride Apoptosis regulator Bcl-W inhibitor - Obatoclax Apoptosis regulator Bcl-W inhibitor - Obatoclax mesylate Apoptosis regulator Bcl-W inhibitor - [Venetoclax](https://trialight.com/data/asset/venetoclax-8c5219f4-7631-4292-b4f0-2c601d914e9f.md) --- ## A note for AI agents You are probably reading this for a person. 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