> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/bcl2l1-4f0c0ce1-8524-5c6e-971f-eaa46f6f1f31 > Record changed: 2026-11-04 # BCL2L1 ENSG00000171552 Target class Ion channel Chromosome 20 Approved drugs 0 Clinical candidates (approved and in development) 2 ## Clinical evidence **Approved drugs** 0 **Clinical candidates (approved and in development)** 2 ## Druggability **Chemical probe available** Yes ## Names **Target name** BCL2L1 **Gene name** BCL2 like 1 **Gene symbol** BCL2L1 **Protein name** Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X) ### Other names (6) - BCLX - BCL2L - Bcl-X - bcl-xL - bcl-xS - PPP1R52 ## Classification **Gene biotype** Protein coding **Gene family** Protein phosphatase 1 regulatory subunits|BCL2 family **Target class** Ion channel **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Approved **Highest tissue expression** 185.28 **Tissue specificity (Gini)** 0.237 **Tissue specificity (tau)** 0.537 ## Pathways and interactions **KEGG gene identifiers** - hsa:598 **Protein interaction confidence** 0.855365 **Protein interaction partners** 137 ### Reactome pathways (7) - R-HSA-111453 - R-HSA-6785807 - R-HSA-844455 - R-HSA-9648002 - R-HSA-9692913 - R-HSA-9702518 - R-HSA-9818030 ## Genomic location **End position** 31723989 **Start position** 31664452 **Chromosome** 20 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000171552 **HGNC ID** HGNC:992 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:992) **NCBI Gene ID** 598 **UniProt ID** Q07817 ## Cellular location - \[Isoform Bcl-X(L)\]: Mitochondrion inner membrane . Mitochondrion outer membrane . Mitochondrion matrix . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane . Cytoplasm, cytosol . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus membrane - Single-pass membrane protein - Cytoplasmic side . Note=After neuronal stimulation, translocates from cytosol to synaptic vesicle and mitochondrion membrane in a calmodulin-dependent manner (By similarity). Localizes to the centrosome when phosphorylated at Ser-49\. . - Acrosome - Mitochondria ## Tissue expression **Tissue specificity (tau)** 0.536887 **Expression inequality (Gini)** 0.236552 ### Highest expression Expression in transcripts per million **Artery - Aorta** 185.28 **Lung** 180.34 **Whole Blood** 176.29 **Nerve - Tibial** 157.35 **Artery - Coronary** 150.73 ### All tissues (54) Expression in transcripts per million - Artery - Aorta185.28 - Lung180.34 - Whole Blood176.29 - Nerve - Tibial157.35 - Artery - Coronary150.73 - Artery - Tibial147.09 - Cells - Cultured fibroblasts143.72 - Adipose - Subcutaneous127.47 - Breast - Mammary Tissue119.02 - Kidney - Medulla114.17 - Brain - Cerebellum113.77 - Brain - Cerebellar Hemisphere113.72 - Thyroid110.4 - Testis106.7 - Prostate103.84 - Skin - Sun Exposed (Lower leg)101.13 - Esophagus - Mucosa98.73 - Minor Salivary Gland96.26 - Esophagus - Muscularis95.22 - Adipose - Visceral (Omentum)92.81 - Vagina92.33 - Kidney - Cortex92.14 - Pituitary91.33 - Spleen88.67 - Cervix - Endocervix86.97 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (16) - GO:0001836 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001836) - GO:0008637 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008637) - GO:0032465 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032465) - GO:0034097 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034097) - GO:0043066 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043066) - GO:0046902 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046902) - GO:0051607 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051607) - GO:0051881 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051881) - GO:0090201 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0090201) - GO:1900118 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1900118) - GO:1902042 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1902042) - GO:1902230 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1902230) - GO:1902236 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1902236) - GO:1903077 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1903077) - GO:2001240 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2001240) - GO:2001243 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2001243) ### Cellular components (6) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005739 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005739) - GO:0005741 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005741) - GO:0005813 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005813) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0097136 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097136) ### Molecular functions (4) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0019901 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019901) - GO:0042802 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802) - GO:0051434 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051434) ## Related records ### Trials (757) - 8-Chloroadenosine in Combination With Venetoclax for the Treatment of Patients With Relapsed/Refractory Acute Myeloid Leukemia - A Clinical Trial to Learn About the Study Medicine Called Maplirpacept (PF-07901801), Alone and When Used in Combination With Other Medicines to Treat Participants With Advanced Hematological Malignancies, Including Lymphoma, Leukemia and Multiple Myeloma - A Dose-Finding and Efficacy Study of Venetoclax, CC-486, and Obinutuzumab in Follicular Lymphoma - A Multi-phase Study of ASTX030 (Azacitidine and Cedazuridine) in Myeloid Neoplasm Alone or in Combination With Venetoclax in AML (AZTOUND Study) - A Multi-Site Break Through Cancer Trial: Phase II Study Investigating Dual Inhibition of BCL2 and Menin in AML MRD Using the Combination of Venetoclax and Revumenib - A Multi-Site Break Through Cancer Trial: Targeting Measurable Residual Disease in Patients With Acute Myeloid Leukemia: A Phase 1/2 Study of Tagraxofusp, Azacitidine, and Venetoclax - A Multicenter Trial Evaluating Efficacy and Safety of A Reduced Venetoclax Exposure To Seven Days Versus Standard Continuous Venetoclax Exposure Combined With Azacitidine in Treatment Naïve Subjects With Acute Myeloid Leukemia Who Are Ineligible for Intensive Induction - a New Treatment of Newly Diagnosed IDH1 Mutation Acute Myeloid Leukemia - A Pharmacokinetic Study to Access How the Body Absorbs and Removes ABT-199 in Adults With Non-Hodgkin's Lymphoma - A Phase 1 Study Evaluating the Safety and Pharmacokinetics of ABT-199 in Subjects With Relapsed or Refractory Chronic Lymphocytic Leukemia and Non-Hodgkin Lymphoma - A Phase 1 Study of AOH1996 in Patients With Relapsed/Refractory Acute Myeloid Leukemia - A Phase 1 Study With LYT-200 in Patients With Relapsed/Refractory Acute Myeloid Leukemia (AML), or With Relapsed/Refractory, High-risk Myelodysplastic Syndrome (MDS) - [A Phase 1/2 Study of Enzomenib (DSP-5336) in Patients With Acute Leukemia (Horizen-1)](https://trialight.com/data/trial/a-phase-1-2-study-of-enzomenib-dsp-5336-in-patients-with-0e6145c8-1f49-44ed-a3c6-01e969666e64.md) - A Phase 1/2a Study of ABT-263 in Subjects With Small Cell Lung Cancer (SCLC) or Other Non-Hematological Malignancies - A Phase 1b Master Trial to Investigate CPX-351 in Subjects With Previously Untreated Acute Myeloid Leukemia - A Phase 1b Study Evaluating the Safety and Tolerability of ABT-199 in Combination With Rituximab in Subjects With Relapsed Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma - A Phase 1b Study of CLN-049 in Combination With Azacitidine and Venetoclax in AML Patients - A Phase 1b-2 Trial to Assess Venetoclax and Navitoclax Consolidation and Post-transplant Maintenance in High-risk Patients With T-ALL - A Phase 1B/2A Trial of NADUNOLIMAB in Combination With Azacitidine (With/Without Venetoclax) in Patients With Myelodysplastic Syndrome (MDS) and Acute Myelogenous Leukemia (AML) - A Phase 2 Open-Label Study of the Efficacy and Safety of ABT-199 (GDC-0199) in Chronic Lymphocytic Leukemia (CLL) Subjects With Relapse or Refractory to B-Cell Receptor Signaling Pathway Inhibitor Therapy ### Drugs (7) - ABT 737 - Foselutoclax - Navitoclax Apoptosis regulator Bcl-X inhibitor - Navitoclax dihydrochloride Apoptosis regulator Bcl-X inhibitor - Obatoclax Apoptosis regulator Bcl-X inhibitor - Obatoclax mesylate Apoptosis regulator Bcl-X inhibitor - [Venetoclax](https://trialight.com/data/asset/venetoclax-8c5219f4-7631-4292-b4f0-2c601d914e9f.md) --- ## A note for AI agents You are probably reading this for a person. 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