> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/bcl2-94d4972e-5aed-5302-9273-508452c6411a > Record changed: 2026-10-13 # BCL2 ENSG00000171791 Target class Ion channel Chromosome 18 Approved drugs 1 Clinical candidates (approved and in development) 4 ## Clinical evidence **Approved drugs** 1 **Clinical candidates (approved and in development)** 4 ## Druggability **Chemical probe available** Yes ## Names **Target name** BCL2 **Gene name** BCL2 apoptosis regulator **Gene symbol** BCL2 **Protein name** Apoptosis regulator Bcl-2 ### Other names (2) - Bcl-2 - PPP1R50 ## Classification **Gene biotype** Protein coding **Gene family** Protein phosphatase 1 regulatory subunits|BCL2 family **Target class** Ion channel **Target type** Human gene ## Expression and localisation **Tissues expressed in** 51 **Protein localisation evidence grade** Enhanced **Highest tissue expression** 49.69 **Tissue specificity (Gini)** 0.469 **Tissue specificity (tau)** 0.869 ## Pathways and interactions **KEGG gene identifiers** - hsa:596 **Protein interaction confidence** 0.839151 **Protein interaction partners** 271 ### Reactome pathways (8) - R-HSA-111447 - R-HSA-111453 - R-HSA-6785807 - R-HSA-844455 - R-HSA-9018519 - R-HSA-9634638 - R-HSA-9818030 - R-HSA-9824594 ## Genomic location **End position** 63320128 **Start position** 63123346 **Chromosome** 18 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000171791 **HGNC ID** HGNC:990 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:990) **NCBI Gene ID** 596 **UniProt ID** P10415 ## Cellular location - Mitochondrion outer membrane - Single-pass membrane protein . Nucleus membrane - Single-pass membrane protein . Endoplasmic reticulum membrane - Single-pass membrane protein . Cytoplasm . - Mitochondria ### Publication evidence (2) - PubMed 21358617 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/21358617/) - PubMed 2250705 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/2250705/) ## Tissue expression **Tissue specificity (tau)** 0.868976 **Expression inequality (Gini)** 0.469246 ### Highest expression Expression in transcripts per million **Cells - EBV-transformed lymphocytes** 49.69 **Nerve - Tibial** 23.76 **Thyroid** 21.33 **Cervix - Ectocervix** 17.92 **Uterus** 17.47 ### All tissues (54) Expression in transcripts per million - Cells - EBV-transformed lymphocytes49.69 - Nerve - Tibial23.76 - Thyroid21.33 - Cervix - Ectocervix17.92 - Uterus17.47 - Ovary15.53 - Cervix - Endocervix15.23 - Fallopian Tube12.88 - Spleen11.31 - Breast - Mammary Tissue11.27 - Adipose - Subcutaneous10.63 - Vagina10.21 - Artery - Coronary8.69 - Artery - Aorta8.19 - Esophagus - Muscularis8.09 - Adipose - Visceral (Omentum)8 - Esophagus - Gastroesophageal Junction7.91 - Prostate7.71 - Small Intestine - Terminal Ileum7.54 - Artery - Tibial7.35 - Colon - Sigmoid6.69 - Bladder6.45 - Pituitary5.81 - Skin - Not Sun Exposed (Suprapubic)5.19 - Skin - Sun Exposed (Lower leg)5.16 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (29) - GO:0000209 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000209) - GO:0006915 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006915) - GO:0006959 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006959) - GO:0006974 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006974) - GO:0008284 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008284) - GO:0008625 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008625) - GO:0009410 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009410) - GO:0009636 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009636) - GO:0010039 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010039) - GO:0010507 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010507) - GO:0030307 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030307) - GO:0030890 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030890) - GO:0032469 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032469) - GO:0034097 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034097) - GO:0035094 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035094) - GO:0042100 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042100) - GO:0043066 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043066) - GO:0043524 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043524) - GO:0050853 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050853) - GO:0051402 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051402) - GO:0051607 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051607) - GO:0051902 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051902) - GO:0051924 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051924) - GO:0070059 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070059) - GO:1902166 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1902166) And 4 more, listed on the interactive page. ### Cellular components (10) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005739 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005739) - GO:0005741 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005741) - GO:0005783 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005783) - GO:0005789 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005789) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) - GO:0031965 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031965) - GO:0032991 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032991) - GO:0046930 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046930) ### Molecular functions (11) - GO:0002020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002020) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0015267 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015267) - GO:0016248 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016248) - GO:0031625 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031625) - GO:0042802 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802) - GO:0043565 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043565) - GO:0046982 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046982) - GO:0051434 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051434) - GO:0060090 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060090) - GO:0140297 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140297) ## Off-target safety - regulation of transcription factor activity ### Studies (2) - cell-based: LTEA\_HepaRG\_BCL2is one of 100 assay component(s) measured in the LTEA HepaRG cell culture assay. It is a marker of Cell proliferation, survival, death. - cell-based: LTEA\_HepaRG\_BCL2is one of 100 assay component(s) measured in the LTEA HepaRG cell culture assay. It is a marker of Cell proliferation, survival, death. ### Biological samples - HepaRG, cell line Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) ## Related records ### Trials (868) - 8-Chloroadenosine in Combination With Venetoclax for the Treatment of Patients With Relapsed/Refractory Acute Myeloid Leukemia - A Clinical Study of VA-CAG as Induction Therapy in Newly Diagnosed AML Patients - A Clinical Trial to Learn About the Study Medicine Called Maplirpacept (PF-07901801), Alone and When Used in Combination With Other Medicines to Treat Participants With Advanced Hematological Malignancies, Including Lymphoma, Leukemia and Multiple Myeloma - A Dose-Finding and Efficacy Study of Venetoclax, CC-486, and Obinutuzumab in Follicular Lymphoma - A Multi-phase Study of ASTX030 (Azacitidine and Cedazuridine) in Myeloid Neoplasm Alone or in Combination With Venetoclax in AML (AZTOUND Study) - A Multi-Site Break Through Cancer Trial: Phase II Study Investigating Dual Inhibition of BCL2 and Menin in AML MRD Using the Combination of Venetoclax and Revumenib - A Multi-Site Break Through Cancer Trial: Targeting Measurable Residual Disease in Patients With Acute Myeloid Leukemia: A Phase 1/2 Study of Tagraxofusp, Azacitidine, and Venetoclax - A Multicenter RCT of "3+7" vs Venetoclax + CACAG in Newly Diagnosed Mid/High-Risk AML Patients - A Multicenter Trial Evaluating Efficacy and Safety of A Reduced Venetoclax Exposure To Seven Days Versus Standard Continuous Venetoclax Exposure Combined With Azacitidine in Treatment Naïve Subjects With Acute Myeloid Leukemia Who Are Ineligible for Intensive Induction - A Pharmacokinetic Study to Access How the Body Absorbs and Removes ABT-199 in Adults With Non-Hodgkin's Lymphoma - A Phase 1 Study Evaluating the Safety and Pharmacokinetics of ABT-199 in Subjects With Relapsed or Refractory Chronic Lymphocytic Leukemia and Non-Hodgkin Lymphoma - A Phase 1 Study of AOH1996 in Patients With Relapsed/Refractory Acute Myeloid Leukemia - A Phase 1 Study Of FLAG Chemotherapy In Combination With Lisaftoclax And Pelcitoclax In Patients With Relapsed/Refractory T-Cell Acute Lymphoblastic Leukemia - A Phase 1 Study With LYT-200 in Patients With Relapsed/Refractory Acute Myeloid Leukemia (AML), or With Relapsed/Refractory, High-risk Myelodysplastic Syndrome (MDS) - [A Phase 1/2 Study of Enzomenib (DSP-5336) in Patients With Acute Leukemia (Horizen-1)](https://trialight.com/data/trial/a-phase-1-2-study-of-enzomenib-dsp-5336-in-patients-with-0e6145c8-1f49-44ed-a3c6-01e969666e64.md) - A Phase 1/2a Study of ABT-263 in Subjects With Small Cell Lung Cancer (SCLC) or Other Non-Hematological Malignancies - A Phase 1B Investigator Initiated Study of Safety and Tolerability of Dexamethasone (D) in Combination With Venetoclax-based Low-Intensity Therapy (LIT) in Treatment-Naïve Acute Myeloid Leukemia (AML): DLIT-AML - A Phase 1b Master Trial to Investigate CPX-351 in Subjects With Previously Untreated Acute Myeloid Leukemia - A Phase 1b Study Evaluating the Safety and Tolerability of ABT-199 in Combination With Rituximab in Subjects With Relapsed Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma - A Phase 1b Study of CLN-049 in Combination With Azacitidine and Venetoclax in AML Patients ### Drugs (7) - APG-2575 Apoptosis regulator Bcl-2 inhibitor - Navitoclax Apoptosis regulator Bcl-2 inhibitor - Obatoclax Apoptosis regulator Bcl-2 inhibitor - Obatoclax mesylate Apoptosis regulator Bcl-2 inhibitor - Oblimersen Bcl-2 mRNA antisense inhibitor - Oblimersen sodium Bcl-2 mRNA antisense inhibitor - [Venetoclax](https://trialight.com/data/asset/venetoclax-8c5219f4-7631-4292-b4f0-2c601d914e9f.md) Apoptosis regulator Bcl-2 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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