> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/axl-12923c18-1e54-5887-8c3a-dc4c6e51b8db > Record changed: 2026-10-13 # AXL ENSG00000167601 Target class Kinase Chromosome 19 Approved drugs 2 Clinical candidates (approved and in development) 7 ## Clinical evidence **Approved drugs** 2 **Clinical candidates (approved and in development)** 7 ## Druggability **Chemical probe available** No ## Names **Target name** AXL **Gene name** AXL receptor tyrosine kinase **Gene symbol** AXL **Protein name** Tyrosine-protein kinase receptor UFO (EC 2.7.10.1) (AXL oncogene) ### Other names (4) - UFO - JTK11 - Tyro7 - ARK ## Classification **Gene biotype** Protein coding **Gene family** Receptor tyrosine kinases|Fibronectin type III domain containing|V-set domain containing **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 52 **Protein localisation evidence grade** Supported **Highest tissue expression** 218.55 **Tissue specificity (Gini)** 0.506 **Tissue specificity (tau)** 0.836 ## Pathways and interactions **KEGG gene identifiers** - hsa:558 **Protein interaction confidence** 0.845774 **Protein interaction partners** 31 ### Reactome pathways (2) - R-HSA-4420097 - R-HSA-9918485 ## Genomic location **End position** 41261766 **Start position** 41219174 **Chromosome** 19 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000167601 **HGNC ID** HGNC:905 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:905) **NCBI Gene ID** 558 **UniProt ID** P30530 ## Cellular location - Cell membrane - Single-pass type I membrane protein . - Actin filaments - Plasma membrane - Vesicles ### Publication evidence (3) - PubMed 28076778 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28076778/) - PubMed 29379210 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/29379210/) - PubMed 7896447 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/7896447/) ## Tissue expression **Tissue specificity (tau)** 0.836452 **Expression inequality (Gini)** 0.505675 ### Highest expression Expression in transcripts per million **Cells - Cultured fibroblasts** 218.55 **Artery - Tibial** 142.42 **Artery - Coronary** 100 **Artery - Aorta** 92.13 **Cervix - Endocervix** 91.22 ### All tissues (54) Expression in transcripts per million - Cells - Cultured fibroblasts218.55 - Artery - Tibial142.42 - Artery - Coronary100 - Artery - Aorta92.13 - Cervix - Endocervix91.22 - Adipose - Subcutaneous81.9 - Nerve - Tibial80.46 - Colon - Sigmoid79.93 - Cervix - Ectocervix78.73 - Esophagus - Gastroesophageal Junction75.36 - Uterus72.74 - Esophagus - Muscularis69.34 - Fallopian Tube68.06 - Bladder62.22 - Adipose - Visceral (Omentum)53.19 - Breast - Mammary Tissue49.72 - Vagina47.59 - Lung46.46 - Ovary43.72 - Colon - Transverse38.5 - Thyroid36.22 - Prostate36.21 - Testis35.84 - Spleen35.84 - Skin - Sun Exposed (Lower leg)34.02 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (14) - GO:0001961 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001961) - GO:0006909 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006909) - GO:0007165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165) - GO:0032689 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032689) - GO:0032825 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032825) - GO:0035457 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035457) - GO:0046718 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046718) - GO:0048010 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048010) - GO:0048469 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048469) - GO:0048549 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048549) - GO:0071222 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071222) - GO:0097028 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097028) - GO:1903902 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1903902) - GO:2000669 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2000669) ### Cellular components (5) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0009986 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009986) - GO:0010008 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010008) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) ### Molecular functions (5) - GO:0001618 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001618) - GO:0001786 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001786) - GO:0004713 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004713) - GO:0004714 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004714) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (100) - A Clinical Study of Bemcentinib With Standard of Care Chemoimmunotherapy in Untreated Advanced/Metastatic Non-small Cell Lung Cancer Patients With a Mutation in the STK11 Gene - [A Phase 1/2 Study of Enzomenib (DSP-5336) in Patients With Acute Leukemia (Horizen-1)](https://trialight.com/data/trial/a-phase-1-2-study-of-enzomenib-dsp-5336-in-patients-with-0e6145c8-1f49-44ed-a3c6-01e969666e64.md) - A Phase I/II Study of Gilteritinib and Momelotinib for Patients With Relapsed or Refractory FLT3-Mutated Acute Myeloid Leukemia - A Phase Ib/II Multicenter Open-label Study of Bemcentinib (BGB324) in Patients With AML or MDS - A Safety and Efficacy Study of CC-90009 Combinations in Subjects With Acute Myeloid Leukemia - A Study of Anti-Cancer Therapies Targeting the MAPK Pathway in Patients With Hematologic Malignancies - A Study of ASP2215 (Gilteritinib) by Itself, ASP2215 Combined With Azacitidine or Azacitidine by Itself to Treat Adult Patients Who Have Recently Been Diagnosed With Acute Myeloid Leukemia With a FLT3 Gene Mutation and Who Cannot Receive Standard Chemotherapy - A Study of ASP2215 (Gilteritinib) Combined With Atezolizumab in Patients With Relapsed or Treatment Refractory FMS-like Tyrosine Kinase (FLT3) Mutated Acute Myeloid Leukemia (AML) - A Study of ASP2215 (Gilteritinib), Administered as Maintenance Therapy Following Induction/Consolidation Therapy for Subjects With FMS-like Tyrosine Kinase 3 (FLT3/ITD) Acute Myeloid Leukemia (AML) in First Complete Remission - A Study of ASP2215 in Combination With Erlotinib in Subjects With Epidermal Growth Factor Receptor (EGFR) Activating Mutation-Positive (EGFRm+) Advanced Non-Small-Cell Lung Cancer (NSCLC) Who Have Acquired Resistance to an EGFR Tyrosine Kinase Inhibitor (TKI) - A Study of ASP2215 in Combination With Induction and Consolidation Chemotherapy in Patients With Newly Diagnosed Acute Myeloid Leukemia - A Study of ASP2215 in Combination With Induction and Consolidation Chemotherapy in Patients With Newly Diagnosed Acute Myeloid Leukemia. - A Study of ASP2215 Versus Salvage Chemotherapy in Patients With Relapsed or Refractory Acute Myeloid Leukemia (AML) With FMS-like Tyrosine Kinase (FLT3) Mutation - A Study of ASP2215 Versus Salvage Chemotherapy In Patients With Relapsed or Refractory Acute Myeloid Leukemia (AML) With FMS-like Tyrosine Kinase 3 (FLT3) Mutation - A Study of Bemcentinib for the Treatment of COVID-19 in Hospitalised Patients - A Study of BGB324 (Bemcentinib) in Combination With Erlotinib in Patients With Non-Small Cell Lung Cancer - A Study of Gilteritinib (ASP2215) Combined With Chemotherapy in Children, Adolescents and Young Adults With FMS-like Tyrosine Kinase 3 (FLT3)/Internal Tandem Duplication (ITD) Positive Relapsed or Refractory Acute Myeloid Leukemia (AML) - A Study of Gilteritinib in Adults With Advanced ALK-positive Non-small Cell Lung Cancer (NSCLC) - A Study of Gilteritinib in Combination With Ivosidenib or Enasidenib in People With Acute Myeloid Leukemia (AML) - A Study of Gilteritinib Versus Midostaurin in Combination With Induction and Consolidation Therapy Followed by One-year Maintenance in Patients With Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndromes With Excess Blasts-2 With FLT3 Mutations Eligible for Intensive Chemotherapy ### Drugs (7) - Bemcentinib Tyrosine-protein kinase receptor UFO inhibitor - BPI-9016 Tyrosine-protein kinase receptor UFO inhibitor - Enapotamab vedotin Tyrosine-protein kinase receptor UFO binding agent - [Gilteritinib](https://trialight.com/data/asset/gilteritinib-68aa5aec-0e4f-4efa-bdc8-eba76c8a8a3a.md) Tyrosine-protein kinase receptor UFO inhibitor - Gilteritinib fumarate Tyrosine-protein kinase receptor UFO inhibitor - Mecbotamab vedotin Tyrosine-protein kinase receptor UFO binding agent - Ningetinib Tyrosine-protein kinase receptor UFO inhibitor --- ## A note for AI agents You are probably reading this for a person. 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