> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/avpr2-9e511853-9fb7-5fbc-83e8-ec6d25930de7 > Record changed: 2026-10-13 # AVPR2 ENSG00000126895 Target class GPCR Chromosome X Approved drugs 8 Clinical candidates (approved and in development) 12 ## Clinical evidence **Approved drugs** 8 **Clinical candidates (approved and in development)** 12 ## Druggability **Chemical probe available** Yes ## Names **Other names** - V2R **Target name** AVPR2 **Gene name** Arginine vasopressin receptor 2 **Gene symbol** AVPR2 **Protein name** Vasopressin V2 receptor (V2R) (AVPR V2) (Antidiuretic hormone receptor) (Renal-type arginine vasopressin receptor) ### Previous gene symbols (2) - DIR3 - DIR ## Classification **Gene biotype** Protein coding **Gene family** Arginine vasopressin and oxytocin receptors **Target class** GPCR **Target type** Human gene ## Expression and localisation **Tissues expressed in** 32 **Highest tissue expression** 14.32 **Tissue specificity (Gini)** 0.584 **Tissue specificity (tau)** 0.832 ## Pathways and interactions **KEGG gene identifiers** - hsa:554 **Protein interaction confidence** 0.85144 **Protein interaction partners** 25 ### Reactome pathways (6) - R-HSA-388479 - R-HSA-418555 - R-HSA-432040 - R-HSA-8856825 - R-HSA-8856828 - R-HSA-9036092 ## Genomic location **End position** 153907166 **Start position** 153902531 **Chromosome** X **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000126895 **HGNC ID** HGNC:897 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:897) **NCBI Gene ID** 554 **UniProt ID** P30518 ## Cellular location - Cell membrane - Multi-pass membrane protein . ### Publication evidence (3) - PubMed 23236378 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23236378/) - PubMed 33742150 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/33742150/) - PubMed 33664408 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/33664408/) ## Tissue expression **Tissue specificity (tau)** 0.831704 **Expression inequality (Gini)** 0.583844 ### Highest expression Expression in transcripts per million **Adipose - Subcutaneous** 14.32 **Kidney - Medulla** 10.84 **Adipose - Visceral (Omentum)** 10.36 **Breast - Mammary Tissue** 10.25 **Fallopian Tube** 6.52 ### All tissues (54) Expression in transcripts per million - Adipose - Subcutaneous14.32 - Kidney - Medulla10.84 - Adipose - Visceral (Omentum)10.36 - Breast - Mammary Tissue10.25 - Fallopian Tube6.52 - Nerve - Tibial6.4 - Uterus5.96 - Cervix - Ectocervix5.09 - Esophagus - Muscularis4.88 - Esophagus - Gastroesophageal Junction4.67 - Cervix - Endocervix4.3 - Thyroid3.93 - Bladder3.92 - Vagina3.62 - Kidney - Cortex3.31 - Artery - Coronary3.29 - Brain - Cerebellar Hemisphere3.23 - Heart - Left Ventricle3.14 - Brain - Cerebellum2.95 - Skin - Sun Exposed (Lower leg)2.89 - Colon - Sigmoid2.72 - Skin - Not Sun Exposed (Suprapubic)2.53 - Small Intestine - Terminal Ileum2.23 - Prostate2.12 - Heart - Atrial Appendage2.1 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (7) - GO:0003092 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003092) - GO:0007188 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007188) - GO:0007189 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007189) - GO:0007190 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007190) - GO:0007599 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007599) - GO:0008285 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008285) - GO:0070295 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070295) ### Cellular components (7) - GO:0005768 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005768) - GO:0005783 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005783) - GO:0005794 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005794) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0030139 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030139) - GO:0030669 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030669) - GO:0048471 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048471) ### Molecular functions (2) - GO:0005000 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005000) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (423) - "SALT Trial" Study of Ascending Levels of Tolvaptan in Hyponatremia - 1-deamino 8-d-arginine Vasopressin (DDAVP) in Percutaneous Ultrasound-guided Renal Biopsy - 2- Day vs. 5- Day Terlipressin and Ceftriaxone in the Control Acute Gastroesophageal Variceal Hemorrhage - 8-Week Study of Tolvaptan Dose Forms in Autosomal Dominant Polycystic Kidney Disease (ADPKD) - A 6-week Open Label Cross-over Study With 2 Different Daily Doses of Minirin® Oral Lyophilisate in Children and Adolescents With Primary Nocturnal Enuresis (PNE) - A Clinical Pharmacological Study of OPC-41061 in the Treatment of Cardiac Edema (Congestive Heart Failure) - A Dose-defining Study of OPC-41061 in Treatment of Hepatic Edema - A Dose-finding Study of OPC-41061 in Treatment of Cardiac Edema (Congestive Heart Failure) - A Double-blind, Placebo-controlled Study of OPC-41061 in the Treatment of Cardiac Edema (Congestive Heart Failure) - A Long-term Administration Study of OPC-41061 in Patients With Autosomal Dominant Polycystic Kidney Disease (ADPKD) (2) \[Extension of Study 156-05-002\] - A Long-term Administration Study of OPC-41061 in Patients With Autosomal Dominant Polycystic Kidney Disease (ADPKD) \[Extension of Study 156-04-001\] - A Multicenter Trial to Investigate the Efficacy and Safety of Tolvaptan in Patients With Hyponatremia in SIADH - A Multicenter, Open-label, Dose-finding Trial of OPC-41061 to Investigate Efficacy, Pharmacokinetics, Pharmacodynamics, and Safety in Patients With Carcinomatous Edema (Phase 2) - A Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Tolerability of Oral Lixivaptan Capsules in Subjects With Euvolemic Hyponatremia - A New Check-list Method for Nocturnal Enuresis - A Phase 2 Efficacy and Safety Study of the Tolvaptan Tablets in Patients With Non-hypovolemic Non-acute Hyponatremia - A Phase 2, Multi-center, Open-label, Dose-finding Trial to Investigate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of OPC-41061 in Patients With Chronic Renal Failure Undergoing Hemodialysis or Hemodiafiltration - A Phase III Study Evaluating the Efficacy and Safety of Satavaptan Versus Placebo in Patients With Dilutional Hyponatremia - A PK Study of 3 Dosages of Tolvaptan in Patients With Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) - A Placebo-Controlled, Double-Blind Study to Confirm the Reversal of Hepatorenal Syndrome Type 1 With Terlipressin ### Drugs (14) - Argipressin tannate Vasopressin receptor agonist - Conivaptan Vasopressin V2 receptor antagonist - Conivaptan hydrochloride Vasopressin V2 receptor antagonist - Desmopressin Vasopressin receptor agonist - Desmopressin acetate Vasopressin receptor agonist - Lixivaptan Vasopressin V2 receptor antagonist - Lypressin Vasopressin receptor agonist - Mozavaptan Vasopressin V2 receptor antagonist - Pecavaptan Vasopressin V2 receptor antagonist - Satavaptan Vasopressin V2 receptor antagonist - Terlipressin Vasopressin V2 receptor binding agent - Tolvaptan Vasopressin V2 receptor antagonist - [Vasopressin](https://trialight.com/data/asset/vasopressin-592303bd-1d7e-43c7-af55-8c1dcb6024f0.md) Vasopressin receptor agonist - Vasopressin tannate Vasopressin V2 receptor agonist --- ## A note for AI agents You are probably reading this for a person. 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