> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/avpr1b-23475468-807c-5646-8f15-f2cc20d96829 > Record changed: 2026-10-13 # AVPR1B ENSG00000198049 Target class GPCR Chromosome 1 Approved drugs 5 Clinical candidates (approved and in development) 7 ## Clinical evidence **Approved drugs** 5 **Clinical candidates (approved and in development)** 7 ## Druggability **Chemical probe available** Yes ## Names **Target name** AVPR1B **Gene name** Arginine vasopressin receptor 1B **Gene symbol** AVPR1B **Previous gene symbols** - AVPR3 **Protein name** Vasopressin V1b receptor (V1bR) (AVPR V1b) (AVPR V3) (Antidiuretic hormone receptor 1b) (Vasopressin V3 receptor) ### Other names (2) - V1bR - VPR3 ## Classification **Gene biotype** Protein coding **Gene family** Arginine vasopressin and oxytocin receptors **Target class** GPCR **Target type** Human gene ## Expression and localisation **Tissues expressed in** 1 **Highest tissue expression** 8.24 **Tissue specificity (Gini)** 0.936 **Tissue specificity (tau)** 0.994 ## Pathways and interactions **KEGG gene identifiers** - hsa:553 **Protein interaction confidence** 0.875643 **Protein interaction partners** 14 ### Reactome pathways (3) - R-HSA-388479 - R-HSA-416476 - R-HSA-5619099 ## Genomic location **End position** 206117699 **Start position** 206106936 **Chromosome** 1 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000198049 **HGNC ID** HGNC:896 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:896) **NCBI Gene ID** 553 **UniProt ID** P47901 ## Cellular location - Cell membrane - Multi-pass membrane protein . ### Publication evidence - PubMed 33713620 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/33713620/) ## Tissue expression **Tissue specificity (tau)** 0.993932 **Expression inequality (Gini)** 0.936044 ### Highest expression Expression in transcripts per million **Pituitary** 8.24 **Brain - Cerebellum** 0.7 **Brain - Cerebellar Hemisphere** 0.61 **Stomach** 0.27 **Small Intestine - Terminal Ileum** 0.13 ### All tissues (54) Expression in transcripts per million - Pituitary8.24 - Brain - Cerebellum0.7 - Brain - Cerebellar Hemisphere0.61 - Stomach0.27 - Small Intestine - Terminal Ileum0.13 - Colon - Transverse0.11 - Colon - Sigmoid0.1 - Kidney - Cortex0.1 - Thyroid0.09 - Kidney - Medulla0.09 - Pancreas0.08 - Fallopian Tube0.07 - Uterus0.03 - Brain - Frontal Cortex (BA9)0.03 - Brain - Hypothalamus0.03 - Brain - Anterior cingulate cortex (BA24)0.03 - Brain - Cortex0.03 - Cells - EBV-transformed lymphocytes0.02 - Bladder0.02 - Cervix - Ectocervix0.02 - Cervix - Endocervix0.02 - Spleen0.02 - Minor Salivary Gland0.02 - Testis0.01 - Skin - Not Sun Exposed (Suprapubic)0.01 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (8) - GO:0007186 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007186) - GO:0007200 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007200) - GO:0007204 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007204) - GO:0042127 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042127) - GO:0043410 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043410) - GO:0046718 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046718) - GO:0060732 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060732) - GO:0090238 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0090238) ### Cellular components (3) - GO:0005768 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005768) - GO:0005794 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005794) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) ### Molecular functions (3) - GO:0005000 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005000) - GO:0005080 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005080) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (277) - 1-deamino 8-d-arginine Vasopressin (DDAVP) in Percutaneous Ultrasound-guided Renal Biopsy - 2- Day vs. 5- Day Terlipressin and Ceftriaxone in the Control Acute Gastroesophageal Variceal Hemorrhage - A 6-week Open Label Cross-over Study With 2 Different Daily Doses of Minirin® Oral Lyophilisate in Children and Adolescents With Primary Nocturnal Enuresis (PNE) - A New Check-list Method for Nocturnal Enuresis - A Placebo-Controlled, Double-Blind Study to Confirm the Reversal of Hepatorenal Syndrome Type 1 With Terlipressin - A SAD/MAD Study of Safety, Tolerability and Pharmacologic Activity of BT200 in Normal Volunteers - A Study of Minirin Melt in Japanese Patients With Central Diabetes Insipidus (CDI). - A Study of Terlipressin in Patients With Hepatorenal Syndrome Type 1 - A Trial to Investigate Efficacy, Safety and Tolerability of FE 201836 for Nocturia Due to Nocturnal Polyuria in Adults - ACid Tranexamic or Terlipressin for Initial Emergency Treatment of Mild to seVere hEmoptysis: a Randomized Trial. - Adding Desmopressin to Tamsulosin for Treatment of BPH - An Eight-week Study Evaluating the Efficacy and Tolerability of Two Doses of SSR149415 in Outpatients With Generalized Anxiety Disorder - An Eight-Week Study Evaluating the Efficacy and Tolerability of Two Doses of SSR149415 in Outpatients With Major Depressive Disorder - An Eight-Week Study Evaluating the Efficacy of Two Fixed Doses (250 mg Twice Daily and 100 mg Twice Daily) of SSR149415 in Patients With Major Depressive Disorder - An Exploratory Haemodynamic Study in Patients With Compensated Cirrhosis and Portal Hypertension - An Extension Study Investigating the Efficacy and Safety of a Fast-Dissolving ("Melt") Formulation of Desmopressin for the Treatment of Nocturia in Adults - Analgesic Efficacy of Intranasal Desmopressin in Acute Renal Colic - Analysis of the Clinical Efficacy of Intravenous Application of Hemostatic Drugs in Improving the Clarity of Vision Under Endoscope, Perioperative Bleeding Volume and Anti-inflammatory Effect of Spinal Endoscopic Lumbar Fusion - Angiotensin II vs. Vasopressin in Septic Shock - Argipressin's Influence on Blood Loss During Hepatic Resection ### Drugs (8) - Argipressin tannate Vasopressin receptor agonist - Desmopressin Vasopressin receptor agonist - Desmopressin acetate Vasopressin receptor agonist - Lypressin Vasopressin receptor agonist - Nelivaptan Vasopressin V1b receptor antagonist - Terlipressin Vasopressin V1 receptor binding agent - [Vasopressin](https://trialight.com/data/asset/vasopressin-592303bd-1d7e-43c7-af55-8c1dcb6024f0.md) Vasopressin receptor agonist - Vasopressin tannate Vasopressin V1b receptor agonist --- ## A note for AI agents You are probably reading this for a person. 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