> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/avpr1a-9e0d16e5-7d9c-530e-8937-823c361e897a
> Record changed: 2026-10-13

# AVPR1A

ENSG00000166148

Target class

GPCR

Chromosome

12

Approved drugs

6

Clinical candidates (approved and in development)

13

## Clinical evidence

**Approved drugs**

6

**ClinGen gene-disease validity**

Disputed

**Clinical candidates (approved and in development)**

13

## Druggability

**Chemical probe available**

Yes

## Names

**Target name**

AVPR1A

**Gene name**

Arginine vasopressin receptor 1A

**Gene symbol**

AVPR1A

**Previous gene symbols**

- AVPR1

**Protein name**

Vasopressin V1a receptor (V1aR) (AVPR V1a) (Antidiuretic hormone receptor 1a) (Vascular/hepatic-type arginine vasopressin receptor)

## Classification

**Gene biotype**

Protein coding

**Gene family**

Arginine vasopressin and oxytocin receptors

**Target class**

GPCR

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

30

**Highest tissue expression**

42.79

**Tissue specificity (Gini)**

0.727

**Tissue specificity (tau)**

0.9

## Pathways and interactions

**KEGG gene identifiers**

- hsa:552

**Protein interaction confidence**

0.876813

**Protein interaction partners**

16

### Reactome pathways (3)

- R-HSA-388479
- R-HSA-416476
- R-HSA-5619099

## Genomic location

**End position**

63151201

**Start position**

63142759

**Chromosome**

12

**Strand**

Reverse

## Identifiers

**Ensembl gene ID**

ENSG00000166148

**HGNC ID**

HGNC:895

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:895)

**NCBI Gene ID**

552

**UniProt ID**

P37288

## Cellular location

- Cell membrane
- Multi-pass membrane protein.

## Tissue expression

**Tissue specificity (tau)**

0.90021

**Expression inequality (Gini)**

0.727495

### Highest expression

Expression in transcripts per million

**Artery - Tibial**

42.79

**Adrenal Gland**

35.5

**Adipose - Visceral (Omentum)**

23.24

**Adipose - Subcutaneous**

22.94

**Cervix - Endocervix**

17.65

### All tissues (54)

Expression in transcripts per million

- Artery - Tibial42.79
- Adrenal Gland35.5
- Adipose - Visceral (Omentum)23.24
- Adipose - Subcutaneous22.94
- Cervix - Endocervix17.65
- Breast - Mammary Tissue13.66
- Thyroid13.55
- Cervix - Ectocervix13.13
- Uterus11.37
- Liver9.97
- Fallopian Tube9.02
- Vagina5.15
- Artery - Coronary4.88
- Bladder4.87
- Nerve - Tibial4.06
- Esophagus - Gastroesophageal Junction3.22
- Skin - Sun Exposed (Lower leg)2.96
- Prostate2.95
- Esophagus - Muscularis2.85
- Colon - Sigmoid2.66
- Kidney - Cortex2.34
- Skin - Not Sun Exposed (Suprapubic)1.93
- Minor Salivary Gland1.73
- Colon - Transverse1.58
- Artery - Aorta1.55

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (4)

- GO:0006091  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006091)
- GO:0007186  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007186)
- GO:0007204  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007204)
- GO:0008015  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008015)

### Cellular components (3)

- GO:0005768  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005768)
- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)
- GO:0030139  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030139)

### Molecular functions (3)

- GO:0005000  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005000)
- GO:0005080  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005080)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)

## On-target safety

- myocardial fibrosis  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - clinical: myocardial fibrosis  
### Biological samples

  - cardiovascular system  
Evidence source  
Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2)
- increased urinary sodium excretion  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: increased urinary sodium excretion  
### Biological samples (3)

  - renal
  - central nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- vasoconstriction  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - clinical: vasoconstriction  
### Biological samples

  - cardiovascular system  
Evidence source  
Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2)
- decreased body temperature  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: decreased body temperature  
### Biological samples (3)

  - renal
  - central nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- heart failure  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - clinical: heart failure  
### Biological samples

  - cardiovascular system  
Evidence source  
Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2)
- myocardial hypertrophy  
### Effects

  - Activation/Increase/Upregulation: chronic  
### Studies

  - preclinical: myocardial hypertrophy  
### Biological samples (3)

  - renal
  - central nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased blood pressure  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: increased blood pressure  
### Biological samples (3)

  - renal
  - central nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased memory  
### Effects

  - Activation/Increase/Upregulation: acute  
### Studies

  - preclinical: increased memory  
### Biological samples (3)

  - renal
  - central nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased anxiety  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: decreased anxiety  
### Biological samples (3)

  - renal
  - central nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- hypertrophy  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - clinical: hypertrophy  
### Biological samples

  - cardiovascular system  
Evidence source  
Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2)
- decreased urinary sodium excretion  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: decreased urinary sodium excretion  
### Biological samples (3)

  - renal
  - central nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased aggression  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: decreased aggression  
### Biological samples (3)

  - renal
  - central nervous system
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)

## Off-target safety

- increased blood pressure  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - preclinical: increased blood pressure  
### Biological samples (2)

  - cardiovascular system
  - renal  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- decreased heart rate  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - preclinical: decreased heart rate  
### Biological samples (2)

  - cardiovascular system
  - renal  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- hyponatraemia  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - preclinical: hyponatraemia  
### Biological samples (2)

  - cardiovascular system
  - renal  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- cardiac hypertrophy  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - preclinical: cardiac hypertrophy  
### Biological samples (2)

  - cardiovascular system
  - renal  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- myocardial fibrosis  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - preclinical: myocardial fibrosis  
### Biological samples (2)

  - cardiovascular system
  - renal  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- receptor binding  
### Studies

  - biochemical: NVS\_GPCR\_hV1A, is one of one assay component(s) measured or calculated from the NVS\_GPCR\_hV1A assay. It is designed to make measurements of radioligand binding, a form of binding reporter, as detected with scintillation counting signals by Filter-based radiodetection technology.  
### Biological samples

  - cell-free  
Evidence source  
Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data)
- water retention in body  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - preclinical: water retention in body  
### Biological samples (2)

  - cardiovascular system
  - renal  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)

## Related records

### Trials (325)

- 1-deamino 8-d-arginine Vasopressin (DDAVP) in Percutaneous Ultrasound-guided Renal Biopsy
- 2- Day vs. 5- Day Terlipressin and Ceftriaxone in the Control Acute Gastroesophageal Variceal Hemorrhage
- A 6-week Open Label Cross-over Study With 2 Different Daily Doses of Minirin® Oral Lyophilisate in Children and Adolescents With Primary Nocturnal Enuresis (PNE)
- A New Check-list Method for Nocturnal Enuresis
- A Phase 1, Randomized, Double-blind, Placebo-controlled Crossover Study of RG7314 on the Potential Regulation of Higher Brain Functions in Healthy Male Participants: Proof of Mechanism
- A Placebo-Controlled, Double-Blind Study to Confirm the Reversal of Hepatorenal Syndrome Type 1 With Terlipressin
- A SAD/MAD Study of Safety, Tolerability and Pharmacologic Activity of BT200 in Normal Volunteers
- A Single-center Study to Investigate How Quickly and to What Extent a Radioactive Dose of RO5285119 is Absorbed, Metabolized and Eliminated From the Body of Healthy Male Volunteers
- A Study Investigating the Absolute Oral Bioavailability of Balovaptan After Single and Multiple Daily Oral Doses of Balovaptan in Healthy Volunteers
- A Study of Balovaptan in Adults With Autism Spectrum Disorder With a 2-Year Open-Label Extension
- A Study of Minirin Melt in Japanese Patients With Central Diabetes Insipidus (CDI).
- A Study of Multiple Dosing Regimens of IV Conivaptan in Subjects With Euvolemic or Hypervolemic Hyponatremia
- A Study of RG7314 to Investigate Efficacy and Safety in Individuals With Autism Spectrum Disorders (ASD)
- A Study of RO5285119 in Healthy Volunteers
- A Study of Terlipressin in Patients With Hepatorenal Syndrome Type 1
- A Study of the Combination of Multiple Doses of RO5285119 With a Single Dose of Risperidone in Healthy Volunteers
- A Study of the Effect of Multiple Doses of Itraconazole and Fluoxetine on the Pharmacokinetics of a Single Dose of RO5285119 in Healthy Subjects
- A Study to Assess the Effect of Severe Hepatic Impairment on the Pharmacokinetics of Intravenous Conivaptan
- A Study to Assess the Efficacy, Safety and Pharmacokinetics of Intravenous Conivaptan (Vaprisol®) in Pediatric Subjects With Euvolemic or Hypervolemic Hyponatremia
- A Study to Assess the Safety and Effects of Intravenous (IV) Conivaptan on the Hepatic Hemodynamic Response in Cirrhotic Patients

### Drugs (15)

- Argipressin tannate Vasopressin receptor agonist
- Balovaptan Vasopressin V1a receptor antagonist
- Conivaptan Vasopressin V1a receptor antagonist
- Conivaptan hydrochloride Vasopressin V1a receptor antagonist
- Desmopressin Vasopressin receptor agonist
- Desmopressin acetate Vasopressin receptor agonist
- Lypressin Vasopressin receptor agonist
- Pecavaptan Vasopressin V1a receptor antagonist
- Relcovaptan Vasopressin V1a receptor antagonist
- Selepressin Vasopressin V1a receptor agonist
- SRX246 Vasopressin V1a receptor antagonist
- SRX251 Vasopressin V1a receptor antagonist
- Terlipressin Vasopressin V1 receptor binding agent
- [Vasopressin](https://trialight.com/data/asset/vasopressin-592303bd-1d7e-43c7-af55-8c1dcb6024f0.md) Vasopressin receptor agonist
- Vasopressin tannate Vasopressin V1a receptor agonist

---

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