> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/atp4a-cb311620-cbd7-5592-86bf-6eff6bf5e70e > Record changed: 2026-10-13 # ATP4A ENSG00000105675 Target class Transporter Chromosome 19 Approved drugs 10 Clinical candidates (approved and in development) 13 ## Clinical evidence **Approved drugs** 10 **Clinical candidates (approved and in development)** 13 ## Druggability **Chemical probe available** No ## Names **Other names** - ATP6A **Target name** ATP4A **Gene name** ATPase H+/K+ transporting subunit alpha **Gene symbol** ATP4A **Protein name** Potassium-transporting ATPase alpha chain 1 (EC 7.2.2.19) (Gastric H(+)/K(+) ATPase subunit alpha) (Proton pump) ## Classification **Gene biotype** Protein coding **Gene family** ATPase H+/K+ transporting **Target class** Transporter **Target type** Human gene ## Expression and localisation **Tissues expressed in** 7 **Highest tissue expression** 1,206.25 **Tissue specificity (Gini)** 0.976 **Tissue specificity (tau)** 0.999 ## Pathways and interactions **KEGG gene identifiers** - hsa:495 **Reactome pathways** - R-HSA-936837 **Protein interaction confidence** 0.83575 **Protein interaction partners** 28 ## Genomic location **End position** 35563658 **Start position** 35550031 **Chromosome** 19 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000105675 **HGNC ID** HGNC:819 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:819) **NCBI Gene ID** 495 **UniProt ID** P20648 ## Cellular location - Apical cell membrane - Multi-pass membrane protein . Note=Localized in the apical canalicular membrane of parietal cells (PubMed:24188822). . ### Publication evidence - PubMed 24188822 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/24188822/) ## Tissue expression **Tissue specificity (tau)** 0.999353 **Expression inequality (Gini)** 0.975935 ### Highest expression Expression in transcripts per million **Stomach** 1,206.25 **Adrenal Gland** 9.83 **Brain - Cerebellar Hemisphere** 8.63 **Brain - Cerebellum** 8.23 **Pancreas** 5.4 ### All tissues (54) Expression in transcripts per million - Stomach1,206.25 - Adrenal Gland9.83 - Brain - Cerebellar Hemisphere8.63 - Brain - Cerebellum8.23 - Pancreas5.4 - Testis2.02 - Brain - Cortex1.54 - Brain - Frontal Cortex (BA9)0.86 - Thyroid0.85 - Cells - EBV-transformed lymphocytes0.74 - Pituitary0.29 - Brain - Anterior cingulate cortex (BA24)0.26 - Bladder0.17 - Cervix - Ectocervix0.16 - Ovary0.15 - Esophagus - Mucosa0.15 - Small Intestine - Terminal Ileum0.13 - Spleen0.11 - Uterus0.09 - Brain - Spinal cord (cervical c-1)0.09 - Vagina0.09 - Fallopian Tube0.09 - Breast - Mammary Tissue0.08 - Colon - Transverse0.08 - Prostate0.08 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes - GO:0034220 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034220) ### Cellular components (3) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0016324 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016324) ### Molecular functions - GO:0008900 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008900) ## Related records ### Trials (1,435) - "Pharmacodynamic Comparison of Omeprazole Versus Pantoprazole on Platelet Reactivity in Patients With Acute Coronary Syndromes on Dual Antiplatelet Therapy With New P2Y12 Inhibitors" -Trial dOPPLER- - +AGIL Barcelona: Integrated Care for Community-Dwelling Frail Older Adults - 10 vs 14 Days Triple Therapy : H.Pylori Infection Eradication - 10-day Versus 14-day Concomitant PAMC as First-line Treatment Strategy for the Eradication of H. Pylori Infection - 13-C Urea Breath Test Using BreathID System and PPIs (Proton Pump Inhibitors) - 14-day PCAB-based High-dose Dual Therapy and14-day PCAB-based Triple Therapy vs 14-day PPI-based Reverse Hybrid Therapy - 14-day Quadruple Hybrid vs. Concomitant Therapies for Helicobacter Pylori Eradication - 15-day Sequential Therapy for Helicobacter Pylori Infection in Korea - 24-h Energy Expenditure and Anti-obesity Medication - 3D Tissue Engineered Bone Equivalent for Treatment of Traumatic Bone Defects - 5 Day Concomitant Versus 10 Day Sequential Therapy for Eradication of H. Pylori Infection - 7 Days vs. 14 Days of Vonoprazan-based Triple Therapy for H. Pylori Eradication - 7-day High-Dose Vonoprazan-amoxicillin Dual Therapy Versus 14-day Vonoprazan-amoxicillin Dual Therapy for H. Pylori - A "Screen and Treat" Helicobacter Pylori Eradication Trial in Adolescents in Three Regions of Chile - A 14 Week, Randomized, Placebo-Controlled Cross-Over Study of Methylphenidate Hydrochloride Controlled Release Capsules in Adult ADHD With and Without Anxiety Disorder Comorbidity - A 3-Part Study to Determine the Relative Bioavailability of Capsule and Tablet Formulations of GDC-0980, the Effect of Food, and the Effect of Rabeprazole on the Pharmacokinetics of the Tablet - A Bioequivalence (BE) Study of TAK-438 Orally Disintegrating (OD) Tablet - A Bioequivalence Study of 2 Formulations of Rabeprazole Sodium and Evaluation of the Effect of Food on Rabeprazole Sodium in Healthy Adult Volunteers - A Bioequivalence Study of Dexlansoprazole From Doxirazole 60 mg Capsules (Hikma Pharma,Egypt)and Dexilant 60 mg Delayed Release (DR) Capsules (Takeda Pharmaceuticals America Inc., USA) - A Bioequivalence Study of Idiazole 20mg DR Tabs and PARIET® 20 mg DR Tabs After a Single Oral Dose Administration Under Fasting Conditions in Healthy Adults ### Drugs (17) - Abeprazan Potassium-transporting ATPase inhibitor - Dexlansoprazole Potassium-transporting ATPase inhibitor - Esomeprazole Potassium-transporting ATPase inhibitor - Esomeprazole magnesium Potassium-transporting ATPase inhibitor - [Esomeprazole sodium](https://trialight.com/data/asset/esomeprazole-sodium-443a1b83-63ad-4041-bb0b-41c60091bcb8.md) Potassium-transporting ATPase inhibitor - Esomeprazole strontium Potassium-transporting ATPase inhibitor - Ilaprazole Potassium-transporting ATPase inhibitor - [Lansoprazole](https://trialight.com/data/asset/lansoprazole-1f580c6f-7852-4af6-bdcc-8a5822477b51.md) Potassium-transporting ATPase inhibitor - Omeprazole Potassium-transporting ATPase inhibitor - Omeprazole magnesium Potassium-transporting ATPase inhibitor - Pantoprazole Potassium-transporting ATPase inhibitor - Pantoprazole sodium Potassium-transporting ATPase inhibitor - Rabeprazole Potassium-transporting ATPase inhibitor - Rabeprazole sodium Potassium-transporting ATPase inhibitor - [Tegoprazan](https://trialight.com/data/asset/tegoprazan-f2335eec-d19e-4178-aa1b-90007a8fc240.md) Potassium-transporting ATPase blocker - Vonoprazan Potassium-transporting ATPase inhibitor - Vonoprazan fumarate Potassium-transporting ATPase inhibitor --- ## A note for AI agents You are probably reading this for a person. 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