> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/atp1b1-cd8feef1-fad0-52f3-96d3-56125fa8266f > Record changed: 2026-10-13 # ATP1B1 ENSG00000143153 Target class Transporter Chromosome 1 Approved drugs 4 Clinical candidates (approved and in development) 6 ## Clinical evidence **Approved drugs** 4 **Clinical candidates (approved and in development)** 6 ## Druggability **Chemical probe available** No ## Names **Target name** ATP1B1 **Gene name** ATPase Na+/K+ transporting subunit beta 1 **Gene symbol** ATP1B1 **Previous gene symbols** - ATP1B **Protein name** Sodium/potassium-transporting ATPase subunit beta-1 (Sodium/potassium-dependent ATPase subunit beta-1) ## Classification **Gene biotype** Protein coding **Gene family** ATPase Na+/K+ transporting subunits **Target class** Transporter **Target type** Human gene ## Expression and localisation **Tissues expressed in** 53 **Highest tissue expression** 566 **Tissue specificity (Gini)** 0.481 **Tissue specificity (tau)** 0.774 ## Pathways and interactions **KEGG gene identifiers** - hsa:481 **Protein interaction confidence** 0.852147 **Protein interaction partners** 34 ### Reactome pathways (4) - R-HSA-210991 - R-HSA-5578775 - R-HSA-936837 - R-HSA-9679191 ## Genomic location **End position** 169310992 **Start position** 169105697 **Chromosome** 1 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000143153 **HGNC ID** HGNC:804 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:804) **NCBI Gene ID** 481 **UniProt ID** P05026 ## Cellular location - Cell membrane - Single-pass type II membrane protein . Apical cell membrane - Single-pass type II membrane protein . Cell membrane, sarcolemma . Note=Colocalizes with OBSCN at the intercalated disk and sarcolemma in cardiomyocytes. Localizes in long striations at the level of Z and M lines. . ### Publication evidence - PubMed 34011520 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/34011520/) ## Tissue expression **Tissue specificity (tau)** 0.774082 **Expression inequality (Gini)** 0.480777 ### Highest expression Expression in transcripts per million **Brain - Frontal Cortex (BA9)** 566 **Kidney - Medulla** 518.72 **Brain - Spinal cord (cervical c-1)** 362.58 **Kidney - Cortex** 349.7 **Brain - Cerebellar Hemisphere** 328.39 ### All tissues (54) Expression in transcripts per million - Brain - Frontal Cortex (BA9)566 - Kidney - Medulla518.72 - Brain - Spinal cord (cervical c-1)362.58 - Kidney - Cortex349.7 - Brain - Cerebellar Hemisphere328.39 - Brain - Hypothalamus311.61 - Thyroid282.47 - Stomach260.25 - Brain - Hippocampus257.24 - Brain - Anterior cingulate cortex (BA24)255.36 - Minor Salivary Gland222.23 - Brain - Substantia nigra217.96 - Brain - Cerebellum211.44 - Brain - Nucleus accumbens (basal ganglia)207.11 - Muscle - Skeletal201.53 - Brain - Cortex192.16 - Uterus189.84 - Brain - Caudate (basal ganglia)163.28 - Esophagus - Mucosa159.06 - Brain - Amygdala155.43 - Pituitary131.89 - Small Intestine - Terminal Ileum128.63 - Brain - Putamen (basal ganglia)122.96 - Colon - Transverse120.31 - Heart - Left Ventricle98.58 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (13) - GO:0006883 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006883) - GO:0010248 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010248) - GO:0030007 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030007) - GO:0035725 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035725) - GO:0044861 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0044861) - GO:0046034 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046034) - GO:0050821 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050821) - GO:0072659 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0072659) - GO:0086009 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0086009) - GO:0086013 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0086013) - GO:0086064 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0086064) - GO:1903278 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1903278) - GO:1903288 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1903288) ### Cellular components (11) - GO:0005765 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005765) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0005890 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005890) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) - GO:0016324 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016324) - GO:0016328 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016328) - GO:0030315 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030315) - GO:0031090 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031090) - GO:0036126 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0036126) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) - GO:1903561 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1903561) ### Molecular functions (7) - GO:0001671 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001671) - GO:0005391 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005391) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0023026 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0023026) - GO:0030674 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030674) - GO:0051117 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051117) - GO:0141109 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0141109) ## On-target safety - decreased heart rate ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: decreased heart rate ### Biological samples (2) - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - increased urine excretion ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: increased urine excretion ### Biological samples (2) - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - atrioventricular block ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: atrioventricular block ### Biological samples (2) - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - vomiting ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: vomiting ### Biological samples (2) - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - increased cardiac contractility ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: increased cardiac contractility ### Biological samples (2) - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - cardiac arrhythmia ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: cardiac arrhythmia ### Biological samples (2) - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - increased urinary sodium excretion ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: increased urinary sodium excretion ### Biological samples (2) - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - ventricular fibrillation ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: ventricular fibrillation ### Biological samples (2) - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) ## Related records ### Trials (335) - 3D1002 in Combination With Oxycodone Hydrochloride Sustained-release Tablets in Patients With Moderate to Severe Cancer Pain - A 3-Part, Open-Label, Drug-Drug Interaction Study of Concomitant Administration of E2609 With Itraconazole, Rifampin, Digoxin, or Donepezil - A Clinical Drug-Drug Interaction (DDI) Study With Omaveloxolone - A Clinical Study Comparing Anti-HER2 Therapy Combined With Chemotherapy to Chemotherapy Alone as Adjuvant Therapy Following Surgery for Stage IB-II Gastric Cancer With High HER2 Expression. - A Clinical Study to Assess the Effect of Enlicitide on How the Body Processes Digoxin in Healthy Adult Participants (MK-0616-031) - A Clinical Trial of Patients With Melanoma - A Clinical Trial to Evaluate JAB-21822 Drug-drug Interactions in Healthy Subjects - A Clinical Trial to Investigate the Clinical Drug-Drug Interaction of Divarasib With Probe Substrates of P-Glycoprotein and Breast Cancer Resistance Protein in Healthy Participants - A Dose Escalation Study Of PF-06939999 In Participants With Advanced Or Metastatic Solid Tumors - A Drug Drug Interaction (DDI) Study of Baricitinib (LY3009104) and Digoxin in Healthy Participants - A Drug Drug Interaction (DDI) Study of Pirtobrutinib (LOXO-305) and Digoxin (P-Glycoprotein Substrate) in Healthy Participants - A Drug Drug Interaction Study to Evaluate the Effect of VCT220 on the Pharmacokinetics of Repaglinide, Rosuvastatin, and Digoxin in Healthy, Overweight, and Obese Subjects - A Drug Interaction Study of ACH-0145228 - A Drug Interaction Study of Albiglutide and Digoxin - A Drug-Drug Interaction (DDI) Study of HDM1002 With Repaglinide, Atorvastatin, Digoxin and Rosuvastatin in Healthy Subjects and Overweight Subjects. - A Drug-drug Interaction (DDI) Study to Assess the Effect of INC280 on the Pharmacokinetics of Digoxin and Rosuvastatin in Patients With cMET-dysregulated Advanced Solid Tumors - A Drug-Drug Interaction Study Between XW003 and Metformin, Warfarin, Rosuvastatin or Digoxin - A Drug-Drug Interaction Study Evaluating the Perpetrator Potential of DC-806 on Cocktails of CYP450 Enzyme and Transporter Substrates in Healthy Participants - A Drug-drug Interaction Study Evaluating the Perpetrator Potential of LY4100511 (DC-853) on Midazolam, Repaglinide, Digoxin, Rosuvastatin in Healthy Participants - A Drug-Drug Interaction Study in Healthy Volunteers of the Effects of Tucatinib ### Drugs (6) - Acetyldigitoxin Sodium/potassium-transporting ATPase inhibitor - Deslanoside Sodium/potassium-transporting ATPase inhibitor - Digitoxin Sodium/potassium-transporting ATPase inhibitor - [Digoxin](https://trialight.com/data/asset/digoxin-9928e38a-813e-4948-9d65-9088ba40a442.md) Sodium/potassium-transporting ATPase inhibitor - Istaroxime Sodium/potassium-transporting ATPase inhibitor - Lanatoside C Sodium/potassium-transporting ATPase inhibitor --- ## A note for AI agents You are probably reading this for a person. 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