> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/atp1a4-d5da371a-13f7-50be-babb-04e116f82c3c
> Record changed: 2026-10-13

# ATP1A4

ENSG00000132681

Target class

Transporter

Chromosome

1

Approved drugs

4

Clinical candidates (approved and in development)

6

## Clinical evidence

**Approved drugs**

4

**Clinical candidates (approved and in development)**

6

## Druggability

**Chemical probe available**

No

## Names

**Target name**

ATP1A4

**Gene name**

ATPase Na+/K+ transporting subunit alpha 4

**Gene symbol**

ATP1A4

**Previous gene symbols**

- ATP1AL2

**Protein name**

Sodium/potassium-transporting ATPase subunit alpha-4 (Na(+)/K(+) ATPase alpha-4 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-4)

## Classification

**Gene biotype**

Protein coding

**Gene family**

ATPase Na+/K+ transporting subunits

**Target class**

Transporter

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

2

**Highest tissue expression**

27.9

**Tissue specificity (Gini)**

0.85

**Tissue specificity (tau)**

0.993

## Pathways and interactions

**KEGG gene identifiers**

- hsa:480

**Protein interaction confidence**

0.862591

**Protein interaction partners**

22

### Reactome pathways (3)

- R-HSA-5578775
- R-HSA-936837
- R-HSA-9679191

## Genomic location

**End position**

160186980

**Start position**

160151586

**Chromosome**

1

**Strand**

Forward

## Identifiers

**Ensembl gene ID**

ENSG00000132681

**HGNC ID**

HGNC:14073

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:14073)

**NCBI Gene ID**

480

**UniProt ID**

Q13733

## Cellular location

- Cell membrane
- Multi-pass membrane protein . Note=In mature sperm, located in the principle piece of the sperm flagellum.

### Publication evidence

- PubMed 16175638  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/16175638/)

## Tissue expression

**Tissue specificity (tau)**

0.993021

**Expression inequality (Gini)**

0.850272

### Highest expression

Expression in transcripts per million

**Testis**

27.9

**Nerve - Tibial**

1.54

**Muscle - Skeletal**

0.85

**Bladder**

0.85

**Brain - Cerebellum**

0.39

### All tissues (54)

Expression in transcripts per million

- Testis27.9
- Nerve - Tibial1.54
- Muscle - Skeletal0.85
- Bladder0.85
- Brain - Cerebellum0.39
- Brain - Cortex0.37
- Esophagus - Gastroesophageal Junction0.35
- Esophagus - Muscularis0.32
- Brain - Frontal Cortex (BA9)0.31
- Prostate0.3
- Brain - Nucleus accumbens (basal ganglia)0.28
- Colon - Sigmoid0.27
- Brain - Anterior cingulate cortex (BA24)0.27
- Artery - Tibial0.25
- Artery - Aorta0.24
- Spleen0.22
- Brain - Cerebellar Hemisphere0.22
- Brain - Caudate (basal ganglia)0.21
- Brain - Amygdala0.21
- Artery - Coronary0.19
- Breast - Mammary Tissue0.19
- Small Intestine - Terminal Ileum0.14
- Fallopian Tube0.14
- Pituitary0.14
- Adipose - Subcutaneous0.14

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (7)

- GO:0006813  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006813)
- GO:0006814  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006814)
- GO:0030317  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030317)
- GO:0035725  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035725)
- GO:0051453  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051453)
- GO:0071805  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071805)
- GO:1902600  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1902600)

### Cellular components (5)

- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)
- GO:0005890  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005890)
- GO:0097225  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097225)
- GO:0097733  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097733)
- GO:0120200  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0120200)

### Molecular functions (3)

- GO:0005391  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005391)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0019829  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019829)

## On-target safety

- increased urine excretion  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: increased urine excretion  
### Biological samples (2)

  - renal
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- atrioventricular block  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: atrioventricular block  
### Biological samples (2)

  - renal
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- decreased heart rate  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: decreased heart rate  
### Biological samples (2)

  - renal
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- vomiting  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: vomiting  
### Biological samples (2)

  - renal
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased cardiac contractility  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: increased cardiac contractility  
### Biological samples (2)

  - renal
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- cardiac arrhythmia  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: cardiac arrhythmia  
### Biological samples (2)

  - renal
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- increased urinary sodium excretion  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: increased urinary sodium excretion  
### Biological samples (2)

  - renal
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)
- ventricular fibrillation  
### Effects

  - Inhibition/Decrease/Downregulation: acute  
### Studies

  - preclinical: ventricular fibrillation  
### Biological samples (2)

  - renal
  - cardiovascular  
PubMed 28216264  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/)

## Related records

### Trials (335)

- 3D1002 in Combination With Oxycodone Hydrochloride Sustained-release Tablets in Patients With Moderate to Severe Cancer Pain
- A 3-Part, Open-Label, Drug-Drug Interaction Study of Concomitant Administration of E2609 With Itraconazole, Rifampin, Digoxin, or Donepezil
- A Clinical Drug-Drug Interaction (DDI) Study With Omaveloxolone
- A Clinical Study Comparing Anti-HER2 Therapy Combined With Chemotherapy to Chemotherapy Alone as Adjuvant Therapy Following Surgery for Stage IB-II Gastric Cancer With High HER2 Expression.
- A Clinical Study to Assess the Effect of Enlicitide on How the Body Processes Digoxin in Healthy Adult Participants (MK-0616-031)
- A Clinical Trial of Patients With Melanoma
- A Clinical Trial to Evaluate JAB-21822 Drug-drug Interactions in Healthy Subjects
- A Clinical Trial to Investigate the Clinical Drug-Drug Interaction of Divarasib With Probe Substrates of P-Glycoprotein and Breast Cancer Resistance Protein in Healthy Participants
- A Dose Escalation Study Of PF-06939999 In Participants With Advanced Or Metastatic Solid Tumors
- A Drug Drug Interaction (DDI) Study of Baricitinib (LY3009104) and Digoxin in Healthy Participants
- A Drug Drug Interaction (DDI) Study of Pirtobrutinib (LOXO-305) and Digoxin (P-Glycoprotein Substrate) in Healthy Participants
- A Drug Drug Interaction Study to Evaluate the Effect of VCT220 on the Pharmacokinetics of Repaglinide, Rosuvastatin, and Digoxin in Healthy, Overweight, and Obese Subjects
- A Drug Interaction Study of ACH-0145228
- A Drug Interaction Study of Albiglutide and Digoxin
- A Drug-Drug Interaction (DDI) Study of HDM1002 With Repaglinide, Atorvastatin, Digoxin and Rosuvastatin in Healthy Subjects and Overweight Subjects.
- A Drug-drug Interaction (DDI) Study to Assess the Effect of INC280 on the Pharmacokinetics of Digoxin and Rosuvastatin in Patients With cMET-dysregulated Advanced Solid Tumors
- A Drug-Drug Interaction Study Between XW003 and Metformin, Warfarin, Rosuvastatin or Digoxin
- A Drug-Drug Interaction Study Evaluating the Perpetrator Potential of DC-806 on Cocktails of CYP450 Enzyme and Transporter Substrates in Healthy Participants
- A Drug-drug Interaction Study Evaluating the Perpetrator Potential of LY4100511 (DC-853) on Midazolam, Repaglinide, Digoxin, Rosuvastatin in Healthy Participants
- A Drug-Drug Interaction Study in Healthy Volunteers of the Effects of Tucatinib

### Drugs (6)

- Acetyldigitoxin Sodium/potassium-transporting ATPase inhibitor
- Deslanoside Sodium/potassium-transporting ATPase inhibitor
- Digitoxin Sodium/potassium-transporting ATPase inhibitor
- [Digoxin](https://trialight.com/data/asset/digoxin-9928e38a-813e-4948-9d65-9088ba40a442.md) Sodium/potassium-transporting ATPase inhibitor
- Istaroxime Sodium/potassium-transporting ATPase inhibitor
- Lanatoside C Sodium/potassium-transporting ATPase inhibitor

---

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