ATP1A4
ENSG00000132681
Target class
Transporter
Chromosome
1
Approved drugs
4
Clinical candidates (approved and in development)
6
- Approved drugs
- 4
- Clinical candidates (approved and in development)
- 6
- Chemical probe available
- No
- Target name
- ATP1A4
- Gene name
- ATPase Na+/K+ transporting subunit alpha 4
- Gene symbol
- ATP1A4
- Previous gene symbols
- ATP1AL2
- Protein name
- Sodium/potassium-transporting ATPase subunit alpha-4 (Na(+)/K(+) ATPase alpha-4 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-4)
- Gene biotype
- Protein coding
- Gene family
- ATPase Na+/K+ transporting subunits
- Target class
- Transporter
- Target type
- Human gene
- Tissues expressed in
- 2
- Highest tissue expression
- 27.9
- Tissue specificity (Gini)
- 0.85
- Tissue specificity (tau)
- 0.993
- KEGG gene identifiers
- hsa:480
- Protein interaction confidence
- 0.862591
- Protein interaction partners
- 22
- R-HSA-5578775
- R-HSA-936837
- R-HSA-9679191
- End position
- 160186980
- Start position
- 160151586
- Chromosome
- 1
- Strand
- Forward
- Cell membrane
- Multi-pass membrane protein . Note=In mature sperm, located in the principle piece of the sperm flagellum.
Publication evidence
- PubMed 16175638
- Tissue specificity (tau)
- 0.993021
- Expression inequality (Gini)
- 0.850272
Expression in transcripts per million
- Testis
- 27.9
- Nerve - Tibial
- 1.54
- Muscle - Skeletal
- 0.85
- Bladder
- 0.85
- Brain - Cerebellum
- 0.39
Expression in transcripts per million
- Testis27.9
- Nerve - Tibial1.54
- Muscle - Skeletal0.85
- Bladder0.85
- Brain - Cerebellum0.39
- Brain - Cortex0.37
- Esophagus - Gastroesophageal Junction0.35
- Esophagus - Muscularis0.32
- Brain - Frontal Cortex (BA9)0.31
- Prostate0.3
- Brain - Nucleus accumbens (basal ganglia)0.28
- Colon - Sigmoid0.27
- Brain - Anterior cingulate cortex (BA24)0.27
- Artery - Tibial0.25
- Artery - Aorta0.24
- Spleen0.22
- Brain - Cerebellar Hemisphere0.22
- Brain - Caudate (basal ganglia)0.21
- Brain - Amygdala0.21
- Artery - Coronary0.19
- Breast - Mammary Tissue0.19
- Small Intestine - Terminal Ileum0.14
- Fallopian Tube0.14
- Pituitary0.14
- Adipose - Subcutaneous0.14
And 29 more, listed on the interactive page.
- GO:0006813
- GO:0006814
- GO:0030317
- GO:0035725
- GO:0051453
- GO:0071805
- GO:1902600
- GO:0005886
- GO:0005890
- GO:0097225
- GO:0097733
- GO:0120200
- GO:0005391
- GO:0005515
- GO:0019829
increased urine excretion
Effects
- Inhibition/Decrease/Downregulation: acute
Studies
- preclinical: increased urine excretion
- renal
- cardiovascular
PubMed 28216264atrioventricular block
Effects
- Inhibition/Decrease/Downregulation: acute
Studies
- preclinical: atrioventricular block
- renal
- cardiovascular
PubMed 28216264decreased heart rate
Effects
- Inhibition/Decrease/Downregulation: acute
Studies
- preclinical: decreased heart rate
- renal
- cardiovascular
PubMed 28216264vomiting
Effects
- Inhibition/Decrease/Downregulation: acute
Studies
- preclinical: vomiting
- renal
- cardiovascular
PubMed 28216264increased cardiac contractility
Effects
- Inhibition/Decrease/Downregulation: acute
Studies
- preclinical: increased cardiac contractility
- renal
- cardiovascular
PubMed 28216264cardiac arrhythmia
Effects
- Inhibition/Decrease/Downregulation: acute
Studies
- preclinical: cardiac arrhythmia
- renal
- cardiovascular
PubMed 28216264increased urinary sodium excretion
Effects
- Inhibition/Decrease/Downregulation: acute
Studies
- preclinical: increased urinary sodium excretion
- renal
- cardiovascular
PubMed 28216264ventricular fibrillation
Effects
- Inhibition/Decrease/Downregulation: acute
Studies
- preclinical: ventricular fibrillation
- renal
- cardiovascular
PubMed 28216264
Related records
Trials (335)
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- A Clinical Drug-Drug Interaction (DDI) Study With Omaveloxolone
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- A Drug Drug Interaction (DDI) Study of Pirtobrutinib (LOXO-305) and Digoxin (P-Glycoprotein Substrate) in Healthy Participants
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- A Drug Interaction Study of ACH-0145228
- A Drug Interaction Study of Albiglutide and Digoxin
- A Drug-Drug Interaction (DDI) Study of HDM1002 With Repaglinide, Atorvastatin, Digoxin and Rosuvastatin in Healthy Subjects and Overweight Subjects.
- A Drug-drug Interaction (DDI) Study to Assess the Effect of INC280 on the Pharmacokinetics of Digoxin and Rosuvastatin in Patients With cMET-dysregulated Advanced Solid Tumors
- A Drug-Drug Interaction Study Between XW003 and Metformin, Warfarin, Rosuvastatin or Digoxin
- A Drug-Drug Interaction Study Evaluating the Perpetrator Potential of DC-806 on Cocktails of CYP450 Enzyme and Transporter Substrates in Healthy Participants
- A Drug-drug Interaction Study Evaluating the Perpetrator Potential of LY4100511 (DC-853) on Midazolam, Repaglinide, Digoxin, Rosuvastatin in Healthy Participants
- A Drug-Drug Interaction Study in Healthy Volunteers of the Effects of Tucatinib
Drugs (6)
- Acetyldigitoxin Sodium/potassium-transporting ATPase inhibitor
- Deslanoside Sodium/potassium-transporting ATPase inhibitor
- Digitoxin Sodium/potassium-transporting ATPase inhibitor
- Digoxin Sodium/potassium-transporting ATPase inhibitor
- Istaroxime Sodium/potassium-transporting ATPase inhibitor
- Lanatoside C Sodium/potassium-transporting ATPase inhibitor