> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/asic3-99a23f11-ec37-5dfd-86bf-a073055592c4 > Record changed: 2026-11-04 # ASIC3 ENSG00000213199 Target class Ion channel Chromosome 7 ## Druggability **Chemical probe available** No ## Names **Target name** ASIC3 **Gene name** Acid sensing ion channel subunit 3 **Gene symbol** ASIC3 **Previous gene symbols** - ACCN3 **Protein name** Acid-sensing ion channel 3 (ASIC3) (hASIC3) (Amiloride-sensitive cation channel 3) (Neuronal amiloride-sensitive cation channel 3) (Testis sodium channel 1) (hTNaC1) ### Other names (2) - TNaC1 - DRASIC ## Classification **Gene biotype** Protein coding **Gene family** Acid sensing ion channel subunits **Target class** Ion channel **Target type** Human gene ## Expression and localisation **Tissues expressed in** 53 **Protein localisation evidence grade** Approved **Highest tissue expression** 89.79 **Tissue specificity (Gini)** 0.534 **Tissue specificity (tau)** 0.88 ## Pathways and interactions **KEGG gene identifiers** - hsa:9311 **Reactome pathways** - R-HSA-2672351 **Protein interaction confidence** 0.841286 **Protein interaction partners** 7 ## Genomic location **End position** 151052756 **Start position** 151048292 **Chromosome** 7 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000213199 **HGNC ID** HGNC:101 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:101) **NCBI Gene ID** 9311 **UniProt ID** Q9UHC3 ## Cellular location - Cell membrane - Multi-pass membrane protein . Cytoplasm . Note=Preferentially expressed at the plasma membrane of the soma and cellular processes of neurons (By similarity). In part cytoplasmic in cochlea cells (By similarity). Localized in specialized sensory nerve endings (By similarity). . - Cytosol - Nucleoplasm ### Publication evidence (4) - PubMed 10842183 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/10842183/) - PubMed 15317815 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/15317815/) - PubMed 9744806 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/9744806/) - PubMed 9886053 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/9886053/) ## Tissue expression **Tissue specificity (tau)** 0.880243 **Expression inequality (Gini)** 0.533877 ### Highest expression Expression in transcripts per million **Brain - Cerebellum** 89.79 **Brain - Cerebellar Hemisphere** 75.41 **Testis** 47.7 **Pituitary** 34.29 **Cervix - Endocervix** 26.43 ### All tissues (54) Expression in transcripts per million - Brain - Cerebellum89.79 - Brain - Cerebellar Hemisphere75.41 - Testis47.7 - Pituitary34.29 - Cervix - Endocervix26.43 - Brain - Spinal cord (cervical c-1)20.95 - Cervix - Ectocervix19.05 - Brain - Nucleus accumbens (basal ganglia)17.49 - Uterus17.4 - Brain - Cortex16.89 - Brain - Caudate (basal ganglia)16.27 - Fallopian Tube15.78 - Brain - Hypothalamus15.14 - Brain - Putamen (basal ganglia)14.6 - Colon - Sigmoid13.27 - Ovary12.7 - Nerve - Tibial12.63 - Brain - Frontal Cortex (BA9)12.49 - Prostate10.62 - Brain - Hippocampus9.68 - Brain - Anterior cingulate cortex (BA24)9.61 - Esophagus - Muscularis9.44 - Brain - Substantia nigra9.13 - Esophagus - Gastroesophageal Junction8.64 - Brain - Amygdala8.62 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (2) - GO:0050915 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050915) - GO:0051899 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051899) ### Cellular components - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) ### Molecular functions (4) - GO:0005272 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005272) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0160125 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0160125) - GO:0160128 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0160128) ## Related records ### Trials (1,396) - "Normal Coronary Artery" With Slow Flow Improved by Adenosine Injection, Dipyridamole Treatment and Clinical Follow-up - "NSAIDs in Acute Achilles Tendinopathy: Effect on Pain Control, Leg Stiffness and Functional Recovery in Athletes" - "Supracondylar Radial Nerve Block Guided by Ultrasound Versus Hematoma Block for Analgesic Management in Closed Reduction of Distal Radius Fractures" - \[SOCRATES -Acute Stroke Or Transient IsChaemic Attack TReated With Aspirin or Ticagrelor and Patient OutcomES\] - 1 or 6 Months of Dual Antiplatelet Therapy After Drug-coated Balloon Angioplasty for De-novo Small Coronary Artery Disease - 1-month DAPT Plus 5-month Ticagrelor Monotherapy Versus 12-month DAPT in Patients With Drug-coated Balloon - 162 mg of Aspirin for Prevention of Preeclampsia - 3-Month Discontinuation of Dual Antiplatelet Therapy After Ultimaster Sirolimus-Eluting Stent Implantation - 30-Day Trial of Oral Valtrex or Valtrex Plus Aspirin on Shedding of HSV DNA in Tears and Saliva of Volunteers - A Bioequivalence Study Using Clinical Endpoint for Diclofenac Sodium Gel 1% in Osteoarthritis Knee" - A Clinical Trial of Antiplatelets in Psoriasis - A Clinical Trial to Compare Safety and Effectiveness for Relieving Tenderness of 10% Naproxen Gel vs. a 2.32% Diclofenac Diethylamine Gel in the Treatment of Strains and Bruises of the Legs. - A Clinical Trials of Quick-Acting Heart Reliever for Moderate Coronary Stenosis - A Comparative Evaluation of Diclofenac Sodium Transdermal Patch, Oral Diclofenac Sodium With Intramuscular Injections of Diclofenac Sodium in Patients Suffering From Oral Pain - A Comparative Study of Indobufen and Aspirin in Patients With Coronary Atherosclerosis - A Comparison of NSAIDs for Acute, Non-radicular Low Back Pain. - A Comparison of Proprietary Formulations of Oral Ketamine + Aspirin and Oral Ketamine Alone for Musculoskeletal Pain - A Comparison of Safety and Treatment in Subjects With Osteoarthritis Taking Low Dose Aspirin - A Comparison of Two Therapeutic Strategies for the Treatment of Aspirin-associated Peptic Ulcers - A Crossover Pilot Study of the Effect of Amiloride on Proteinuria ### Drugs (6) - Amiloride - [Aspirin](https://trialight.com/data/asset/aspirin-03870fc6-137e-47aa-9f14-b7ae6754fb15.md) - [Diclofenac](https://trialight.com/data/asset/diclofenac-6bb6f2bf-7068-41cb-8e1d-c1c073cf27b3.md) - Diminazene - Nafamostat - Salicylic acid --- ## A note for AI agents You are probably reading this for a person. 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