> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/ar-a6af2dca-1d81-5967-9bce-dc5b29aacbbc > Record changed: 2026-10-13 # AR ENSG00000169083 Target class Nuclear receptor Chromosome X Approved drugs 23 Clinical candidates (approved and in development) 42 ## Clinical evidence **Approved drugs** 23 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 42 ## Druggability **Chemical probe available** Yes ## Names **Target name** AR **Gene name** Androgen receptor **Gene symbol** AR **Protein name** Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4) ### Other names (4) - AIS - NR3C4 - SMAX1 - HUMARA ### Previous gene symbols (2) - DHTR - SBMA ## Classification **Gene biotype** Protein coding **Gene family** Nuclear receptor subfamily 3 group C **Target class** Nuclear receptor **Target type** Human gene ## Expression and localisation **Tissues expressed in** 38 **Protein localisation evidence grade** Supported **Highest tissue expression** 41.07 **Tissue specificity (Gini)** 0.648 **Tissue specificity (tau)** 0.857 ## Pathways and interactions **KEGG gene identifiers** - hsa:367 **Protein interaction confidence** 0.844571 **Protein interaction partners** 140 ### Reactome pathways (6) - R-HSA-3371497 - R-HSA-383280 - R-HSA-4090294 - R-HSA-5625886 - R-HSA-5689880 - R-HSA-8940973 ## Genomic location **End position** 67730619 **Start position** 67543353 **Chromosome** X **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000169083 **HGNC ID** HGNC:644 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:644) **NCBI Gene ID** 367 **UniProt ID** P10275 ## Cellular location - Nucleus . Cytoplasm . Note=Detected at the promoter of target genes (PubMed:25091737). Predominantly cytoplasmic in unligated form but translocates to the nucleus upon ligand-binding. Can also translocate to the nucleus in unligated form in the presence of RACK1\. . - Cytosol ### Publication evidence (6) - PubMed 12958311 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/12958311/) - PubMed 15634333 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/15634333/) - PubMed 17587566 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/17587566/) - PubMed 19244107 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/19244107/) - PubMed 19345326 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/19345326/) - PubMed 25091737 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/25091737/) ## Tissue expression **Tissue specificity (tau)** 0.856678 **Expression inequality (Gini)** 0.648227 ### Highest expression Expression in transcripts per million **Cervix - Endocervix** 41.07 **Cervix - Ectocervix** 38.53 **Uterus** 26.78 **Fallopian Tube** 22.23 **Vagina** 22.17 ### All tissues (54) Expression in transcripts per million - Cervix - Endocervix41.07 - Cervix - Ectocervix38.53 - Uterus26.78 - Fallopian Tube22.23 - Vagina22.17 - Prostate21.05 - Ovary16.84 - Liver14.9 - Cells - Cultured fibroblasts14.7 - Artery - Aorta12.65 - Breast - Mammary Tissue11.46 - Adipose - Subcutaneous10.39 - Artery - Tibial10.03 - Artery - Coronary7.5 - Bladder7.39 - Testis7.02 - Nerve - Tibial5.57 - Skin - Not Sun Exposed (Suprapubic)5.13 - Adipose - Visceral (Omentum)4.75 - Thyroid4.58 - Muscle - Skeletal4.08 - Skin - Sun Exposed (Lower leg)3.89 - Esophagus - Gastroesophageal Junction3.65 - Heart - Atrial Appendage3.22 - Colon - Sigmoid3.18 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (21) - GO:0000122 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000122) - GO:0007165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165) - GO:0007267 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007267) - GO:0008284 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008284) - GO:0008285 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008285) - GO:0010628 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010628) - GO:0030520 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030520) - GO:0030521 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030521) - GO:0030522 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030522) - GO:0045597 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045597) - GO:0045726 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045726) - GO:0045893 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045893) - GO:0045944 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045944) - GO:0045945 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045945) - GO:0071383 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071383) - GO:0071391 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071391) - GO:0071394 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071394) - GO:0140694 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140694) - GO:1902895 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1902895) - GO:1903076 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1903076) - GO:2001237 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2001237) ### Cellular components (7) - GO:0000785 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000785) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005654 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0016607 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016607) - GO:0032991 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032991) ### Molecular functions (19) - GO:0000976 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000976) - GO:0000977 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000977) - GO:0000978 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000978) - GO:0001091 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001091) - GO:0001223 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001223) - GO:0001228 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001228) - GO:0003682 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003682) - GO:0003700 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003700) - GO:0003707 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003707) - GO:0004879 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004879) - GO:0005102 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005102) - GO:0005497 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005497) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0008013 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008013) - GO:0019899 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019899) - GO:0051117 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051117) - GO:0060090 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060090) - GO:0061629 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0061629) - GO:0140693 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140693) ## On-target safety - increased body weight ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: increased body weight ### Biological samples (2) - central nervous system - endocrine PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - N/A, Impairment of reproductive capacity ### Effects - Inhibition/Decrease/Downregulation ### Studies - cell-based Evidence source Source: [aopwiki.org](https://aopwiki.org/aops/19) - Decrease, Population growth rate ### Effects - Activation/Increase/Upregulation ### Studies - cell-based Evidence source Source: [aopwiki.org](https://aopwiki.org/aops/23) - depression ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: depression ### Biological samples (2) - central nervous system - endocrine PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - osteoporosis ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: osteoporosis ### Biological samples (2) - central nervous system - endocrine PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - death ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: death ### Biological samples (2) - central nervous system - endocrine PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - decreased anxiety ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: decreased anxiety ### Biological samples (2) - central nervous system - endocrine PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - hot flashes ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: hot flashes ### Biological samples (2) - central nervous system - endocrine PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - bone pain ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: bone pain ### Biological samples (2) - central nervous system - endocrine PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - Decrease, Population growth rate ### Effects - Activation/Increase/Upregulation ### Studies - cell-based Evidence source Source: [aopwiki.org](https://aopwiki.org/aops/376) - decreased attention ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: decreased attention ### Biological samples (2) - central nervous system - endocrine PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - decreased memory ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: decreased memory ### Biological samples (2) - central nervous system - endocrine PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - bone metastasis ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: bone metastasis ### Biological samples (2) - central nervous system - endocrine PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - heart attack ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: heart attack ### Biological samples (2) - central nervous system - endocrine PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - anemia ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: anemia ### Biological samples (2) - central nervous system - endocrine PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - Impaired recruitment , Population trajectory ### Effects - Inhibition/Decrease/Downregulation ### Studies - cell-based Evidence source Source: [aopwiki.org](https://aopwiki.org/aops/187) - insulin resistance ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: insulin resistance ### Biological samples (2) - central nervous system - endocrine PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - sexual dysfunction ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: sexual dysfunction ### Biological samples (2) - central nervous system - endocrine PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - drug abuse/dependence ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: drug abuse/dependence ### Biological samples (2) - central nervous system - endocrine PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - Increase, Leydig cell tumors ### Effects - Inhibition/Decrease/Downregulation ### Studies - cell-based Evidence source Source: [aopwiki.org](https://aopwiki.org/aops/111) - increased triglycerides ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: increased triglycerides ### Biological samples (2) - central nervous system - endocrine PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - Increase, hepatocellular adenomas and carcinomas ### Effects - Activation/Increase/Upregulation ### Studies - cell-based Evidence source Source: [aopwiki.org](https://aopwiki.org/aops/117) ## Off-target safety - increased muscle mass ### Effects - Activation/Increase/Upregulation: general ### Studies - preclinical: increased muscle mass ### Biological samples - endocrine PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - decreased spermatogenesis ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - preclinical: decreased spermatogenesis ### Biological samples - endocrine PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - regulation of transcription factor activity ### Studies (7) - cell-based: TOX21\_AR\_LUC\_MDAKB2\_Antagonist\_Specificity, is one of one assay component(s) measured or calculated from the TOX21\_AR\_LUC\_MDAkb2\_Antagonist\_Specificity assay. It is designed to make measurements of luciferase induction, a form of inducible reporter, as detected with bioluminescence signals by luciferase-coupled ATP quantitation technology. - cell-based: TOX21\_AR\_BLA\_Agonist\_ratio is an assay readout measuring reporter gene via receptor activity and designed using inducible reporter (beta lactamase induction) detected with GAL4 b-lactamase reporter gene. The signal is derived from the ratio of cleaved (ch2) to uncleaved (ch1) substrate used as the measure of target activity. - cell-based: TOX21\_AR\_LUC\_MDAKB2\_Agonist, is one of one assay component(s) measured or calculated from the TOX21\_AR\_LUC\_MDAkb2\_Agonist assay. It is designed to make measurements of luciferase induction, a form of inducible reporter, as detected with bioluminescence signals by luciferase-coupled ATP quantitation technology. - cell-based: ATG\_AR\_TRANS, is one of 30 assay component(s) measured or calculated from the ATG\_TRANS assay. It is designed to make measurements of mRNA induction, a form of inducible reporter, as detected with fluorescence intensity signals by Reverse transcription polymerase chain reaction (RT-PCR) and Capillary electrophoresis technology. - cell-based: TOX21\_AR\_LUC\_MDAKB2\_Antagonist is one of one assay component(s) measured or calculated from the TOX21\_AR\_LUC\_MDAkb2\_Antagonist. It is designed to make measurements of luciferase induction, a form of inducible reporter, as detected with bioluminescence signals following addition of luciferin substrate and ATP. - cell-based: TOX21\_AR\_BLA\_Antagonist\_ratio is an assay readout measuring reporter gene via receptor activity and designed using inducible reporter (beta lactamase induction) detected with GAL4 b-lactamase reporter gene. The signal is derived from the ratio of cleaved (ch2) to uncleaved (ch1) reporter gene substrate used as the measure of target activity. - cell-based: ATG\_AR\_TRANS, is one of 30 assay component(s) measured or calculated from the ATG\_TRANS assay. It is designed to make measurements of mRNA induction, a form of inducible reporter, as detected with fluorescence intensity signals by Reverse transcription polymerase chain reaction (RT-PCR) and Capillary electrophoresis technology. ### Biological samples (3) - MDA-kb2, cell line - HEK293T, cell line - HepG2, cell line Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) - androgenicity females ### Effects - Activation/Increase/Upregulation: general ### Studies - preclinical: androgenicity females ### Biological samples - endocrine PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - receptor binding ### Studies - biochemical: NVS\_NR\_hAR, is one of one assay component(s) measured or calculated from the NVS\_NR\_hAR assay. It is designed to make measurements of radioligand binding, a form of binding reporter, as detected with scintillation counting signals by Lysate-based radiodetection technology. ### Biological samples - cell-free Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) - regulation of steroid biosynthetic process ### Studies (4) - cell-based: CEETOX\_H295R\_ANDR, is one of 23 assay component(s) measured or calculated from the CEETOX\_H295R assay. It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. - cell-based: CEETOX\_H295R\_TESTO, is one of 23 assay component(s) measured or calculated from the CEETOX\_H295R assay. It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. - cell-based: CEETOX\_H295R\_TESTO, is one of 23 assay component(s) measured or calculated from the CEETOX\_H295R assay. It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. - cell-based: CEETOX\_H295R\_ANDR, is one of 23 assay component(s) measured or calculated from the CEETOX\_H295R assay. It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. ### Biological samples - H295R, cell line Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) - gynecomastia ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - preclinical: gynecomastia ### Biological samples - endocrine PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - cell proliferation ### Studies (2) - cell-based: ACEA\_AR\_80hr, is one of two assay component(s) measured or calculated from the ACEA\_AR assay. It is designed to make measurements of real-time cell-growth kinetics, a form of growth reporter, as detected with electrical impedance signals by Real-Time Cell Electrode Sensor (RT-CES) technology. - cell-based: ACEA\_AR\_80hr, is one of two assay component(s) measured or calculated from the ACEA\_ER assay. It is designed to make measurements of real-time cell-growth kinetics, a form of growth reporter, as detected with electrical impedance signals by Real-Time Cell Electrode Sensor (RT-CES) technology. ### Biological samples - 22Rv1, cell line Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) - oedema ### Effects - Activation/Increase/Upregulation: general ### Studies - preclinical: oedema ### Biological samples - endocrine PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - regulation of steroid hormone biosynthetic process ### Studies (2) - cell-based: one of 12 assay component(s) measured or calculated from the CEETOX\_H295R assay (11 hormones and 1 viability assay). It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. The concentrations for these components have not been pre-filtered for the maximum tolerated concentration (MTC) based on the MTT assay (\_noMTC). - cell-based: one of 12 assay component(s) measured or calculated from the CEETOX\_H295R assay (11 hormones and 1 viability assay). It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. The concentrations for these components have not been pre-filtered for the maximum tolerated concentration (MTC) based on the MTT assay (\_noMTC). ### Biological samples - H295R, cell line Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) - liver complications ### Effects - Activation/Increase/Upregulation: general ### Studies - preclinical: liver complications ### Biological samples - endocrine PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - sleep apnoea ### Effects - Activation/Increase/Upregulation: general ### Studies - preclinical: sleep apnoea ### Biological samples - endocrine PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - increased hostility ### Effects - Activation/Increase/Upregulation: general ### Studies - preclinical: increased hostility ### Biological samples - endocrine PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - impotence ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - preclinical: impotence ### Biological samples - endocrine PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - mastodynia ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - preclinical: mastodynia ### Biological samples - endocrine PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - protein stabilization ### Studies (2) - cell-based: OT\_AR\_ARSRC1\_0960, is one of one assay component(s) measured or calculated from the OT\_AR\_ARSRC1\_0960 assay. It is designed to make measurements of protein fragment complementation, a form of binding reporter, as detected with fluorescence intensity signals by Protein-fragment Complementation technology. - cell-based: OT\_AR\_ARSRC1\_0480, is one of one assay component(s) measured or calculated from the OT\_AR\_ARSRC1\_0480 assay. It is designed to make measurements of protein fragment complementation, a form of binding reporter, as detected with fluorescence intensity signals by Protein-fragment Complementation technology. ### Biological samples - HEK293T, cell line Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) - increased breast carcinoma ### Effects - Inhibition/Decrease/Downregulation: general ### Studies - preclinical: increased breast carcinoma ### Biological samples - endocrine PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) - increased prostate carcinoma ### Effects - Activation/Increase/Upregulation: general ### Studies - preclinical: increased prostate carcinoma ### Biological samples - endocrine PubMed 23197038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/) ## Related records ### Trials (1,381) - "Effect of CPA/EE Drug on Periodontal Tissue and hsCRP Levels in PCOS Patients With Gingivitis - (Bicalutamide) Casodex vs Placebo in Non-metastatic Early Prostate Cancer - \[18F\] Dihydro-testosterone Pet and MR Imaging In Patients With Localized Prostate Cancer - \[18F\]-Fluoro-2-Deoxy-D-Glucose and -\[18F\] Dihydro-Testosterone Pet Imaging in Patients With Progressive Prostate Cancer - 1% Clascoterone Cream for the Treatment Acne Vulgaris - 14C-ARN-509 Microtracer Label AME and Absolute BA Study - 177Lu-PSMA-617 Combined With Darolutamide in Neoadjuvant Treatment of High-risk Localized Prostate Cancer: a Prospective, Single-arm, Multi-center Clinical Trial - 1911GCCC: Galeterone With Gemcitabine for Patients With Metastatic Pancreatic Adenocarcinoma - 28-Day Study of Testosterone Co-administered With Dutasteride in Hypogonadal Men - 5-Alpha Reductase and Anabolic Effects of Testosterone - 52 Week Study + 24-Month Long-Term Extension of Safety, PK, & Efficacy of XYOSTED® for Testosterone Replacement in Male Adolescents With Hypogonadism - A 2 Part, Phase 2 Trial of Galeterone in the Treatment of Castration Resistant Prostate Cancer - A Bioavailability Study of LY2452473 and Tadalafil - A Canadian Trial of Bicalutamide in Patients Receiving Maintenance Avelumab for Metastatic Urothelial Cancer. - A Clinical and Biological Research of Combined Chinese and Western Medicine in the Treatment of PCOS - A Clinical Study Evaluating The Benefit of Adding Rucaparib to Enzalutamide for Men With Metastatic Prostate Cancer That Has Become Resistant To Testosterone-Deprivation Therapy - [A Clinical Study of Ifinatamab Deruxtecan Based Treatment Combinations or as Monotherapy to Treat Metastatic Castrate Resistant Prostate Cancer (mCRPC) (MK-2400-01A/IDeate-Prostate02)](https://trialight.com/data/trial/a-clinical-study-of-ifinatamab-deruxtecan-based-treatment-99be48a0-44f7-46eb-bdf5-d3d2adc6018e.md) - [A Clinical Study of KTX-2001 in Subjects With Metastatic Castration-Resistant Prostate Cancer (STRIKE-001)](https://trialight.com/data/trial/a-clinical-study-of-ktx-2001-in-subjects-with-metastatic-91eebe70-94e2-44ca-b197-78e0187bba9a.md) - A Clinical Study of QLC5508 and/or QLH12016 in Combination With Other Anti-tumor Therapies in Subjects With Advanced Prostate Cancer - A Clinical Study of SHR-4394 in Combination With Anti-tumor Therapy in Prostate Cancer ### Drugs (42) - Abiraterone Androgen Receptor antagonist - [Apalutamide](https://trialight.com/data/asset/apalutamide-146fbb79-89a1-420c-bc35-0403bd284412.md) Androgen Receptor antagonist - APC-100 Androgen Receptor antagonist - AZD3514 Androgen Receptor modulator - Bicalutamide Androgen Receptor antagonist - Clascoterone Androgen Receptor antagonist - CR 1447 Androgen Receptor agonist - Cyproterone acetate Androgen Receptor antagonist - Danazol Androgen Receptor agonist - [Darolutamide](https://trialight.com/data/asset/darolutamide-58582cea-cd7f-464d-b5cc-049941dce9c1.md) Androgen Receptor antagonist - Dimethylcurcumin Androgen Receptor degrader - Dromostanolone propionate Androgen Receptor agonist - Enobosarm Androgen Receptor modulator - [Enzalutamide](https://trialight.com/data/asset/enzalutamide-d1214ac0-68e5-4752-9999-977e028ec483.md) Androgen Receptor antagonist - Ethylestrenol Androgen Receptor agonist - Fluoxymesterone Androgen Receptor agonist - Flutamide Androgen Receptor antagonist - Galeterone Androgen Receptor antagonist - GLPG0492 Androgen Receptor modulator - GSK2849466 Androgen Receptor modulator --- ## A note for AI agents You are probably reading this for a person. 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