> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/apoc3-d913df30-d08a-5dc6-b7e8-6748f4ee7aa6 > Record changed: 2026-11-04 # APOC3 ENSG00000110245 Target class Unclassified protein Chromosome 11 ## Druggability **Chemical probe available** No ## Names **Target name** APOC3 **Gene name** Apolipoprotein C3 **Gene symbol** APOC3 **Protein name** Apolipoprotein C-III (Apo-CIII) (ApoC-III) (Apolipoprotein C3) ### Other names (5) - Apo-CIII - ApoC-III - APOCIII - Apo-C3 - ApoC-3 ## Classification **Gene biotype** Protein coding **Gene family** Apolipoproteins **Target class** Unclassified protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 5 **Protein localisation evidence grade** Approved **Highest tissue expression** 7,599.74 **Tissue specificity (Gini)** 0.98 **Tissue specificity (tau)** 1 ## Pathways and interactions **KEGG gene identifiers** - hsa:345 **Protein interaction confidence** 0.861947 **Protein interaction partners** 57 ### Reactome pathways (4) - R-HSA-8963888 - R-HSA-8963901 - R-HSA-8964058 - R-HSA-975634 ## Genomic location **End position** 116833343 **Start position** 116827019 **Chromosome** 11 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000110245 **HGNC ID** HGNC:610 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:610) **NCBI Gene ID** 345 **UniProt ID** P02656 ## Cellular location - Secreted . - Cell Junctions - Nucleoli - Nucleoplasm ### Publication evidence (2) - PubMed 18201179 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/18201179/) - PubMed 22510806 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/22510806/) ## Tissue expression **Tissue specificity (tau)** 0.999705 **Expression inequality (Gini)** 0.980072 ### Highest expression Expression in transcripts per million **Liver** 7,599.74 **Small Intestine - Terminal Ileum** 105.64 **Kidney - Cortex** 1.4 **Kidney - Medulla** 1.07 **Testis** 1.02 ### All tissues (54) Expression in transcripts per million - Liver7,599.74 - Small Intestine - Terminal Ileum105.64 - Kidney - Cortex1.4 - Kidney - Medulla1.07 - Testis1.02 - Whole Blood0.59 - Spleen0.56 - Cervix - Ectocervix0.45 - Fallopian Tube0.42 - Lung0.4 - Uterus0.39 - Pituitary0.37 - Cells - Cultured fibroblasts0.37 - Brain - Cerebellum0.37 - Stomach0.36 - Ovary0.35 - Pancreas0.34 - Colon - Transverse0.31 - Adipose - Visceral (Omentum)0.3 - Esophagus - Mucosa0.3 - Prostate0.29 - Artery - Coronary0.26 - Adrenal Gland0.25 - Thyroid0.24 - Vagina0.23 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (23) - GO:0006641 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006641) - GO:0006869 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006869) - GO:0007186 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007186) - GO:0010897 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010897) - GO:0010903 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010903) - GO:0010916 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010916) - GO:0010987 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010987) - GO:0010989 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010989) - GO:0019433 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019433) - GO:0032489 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032489) - GO:0033344 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0033344) - GO:0033700 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0033700) - GO:0034375 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034375) - GO:0034379 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034379) - GO:0034382 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034382) - GO:0042632 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042632) - GO:0043691 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043691) - GO:0045717 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045717) - GO:0045833 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045833) - GO:0048261 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048261) - GO:0050995 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050995) - GO:0060621 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060621) - GO:0070328 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070328) ### Cellular components (7) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005769 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005769) - GO:0034361 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034361) - GO:0034363 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034363) - GO:0034366 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034366) - GO:0042627 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042627) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) ### Molecular functions (5) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0005543 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005543) - GO:0015485 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015485) - GO:0055102 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0055102) - GO:0070653 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070653) ## Related records ### Trials (21) - A Study Comparing Two Subcutaneous Formulations: Vial and Autoinjector (AI) With Olezarsen, at Two Dose Levels, in Healthy Adult Participants - A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRX) Administered to Adults With Familial Chylomicronemia Syndrome (FCS) Previously Treated With Volanesorsen - A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRx) Administered to Patients With Familial Chylomicronemia Syndrome (FCS) - A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRx) in Adults With Hypertriglyceridemia and Atherosclerotic Cardiovascular Disease (Established or at Increased Risk for), and/or With Severe Hypertriglyceridemia - A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRx) in Participants With Familial Chylomicronemia Syndrome (FCS) - A Study of Olezarsen (ISIS 678354) Administered to Participants With Severe Hypertriglyceridemia - [A Study of Olezarsen (ISIS 678354) in Participants With Hypertriglyceridemia and Atherosclerotic Cardiovascular Disease, or With Severe Hypertriglyceridemia](https://trialight.com/data/trial/a-study-of-olezarsen-isis-678354-in-participants-with-3ccff9c9-7155-423c-aecc-7da1b979218d.md) - A Study of Olezarsen Administered Subcutaneously to Participants With Severe Hypertriglyceridemia - A Study of Olezarsen for the Treatment of Familial Chylomicronemia Syndrome (FCS) in Pediatric Participants - A Study to Evaluate the Effect of Volanesorsen on Cardiac Repolarization Conducted in Healthy Volunteers - [CORE-OLE: A Study of Olezarsen (ISIS 678354) Administered Subcutaneously to Participants With Severe Hypertriglyceridemia (SHTG)](https://trialight.com/data/trial/core-ole-a-study-of-olezarsen-isis-678354-administered-c1d29f61-b72a-4a3f-bcf7-7519dbc1b5fe.md) - Efficacy, Safety and Tolerability of ISIS 304801 in People With Partial Lipodystrophy With an Open-Label Extension - Mechanistic Study of ISIS ISIS-APOCIIIRX in Type 2 Diabetes - Olezarsen Early Access Program for Patients With Familial Chylomicronemia Syndrome (FCS) - Safety, Tolerability, PK, and Pharmacodynamics(PD) of IONIS APOCIII-LRx in Healthy Volunteers With Elevated Triglycerides - Study of ISIS 678354 (AKCEA-APOCIII-LRx) in Participants With Hypertriglyceridemia and Established Cardiovascular Disease (CVD) - The Approach Open Label Study: A Study of Volanesorsen (Formerly IONIS-APOCIIIRx) in Participants With Familial Chylomicronemia Syndrome - The APPROACH Study: A Study of Volanesorsen (Formerly IONIS-APOCIIIRx) in Patients With Familial Chylomicronemia Syndrome - The BROADEN Study: A Study of Volanesorsen (Formerly IONIS-APOCIIIRx) in Participants With Familial Partial Lipodystrophy - The COMPASS Study: A Study of Volanesorsen (Formally ISIS-APOCIIIRx) in Patients With Hypertriglyceridemia ### Drugs (3) - [Olezarsen](https://trialight.com/data/asset/olezarsen-2c919b5e-718c-4ee3-b8d5-803e4a3c1a1a.md) Apolipoprotein C-III mRNA antisense inhibitor - Volanesorsen Apolipoprotein C-III mRNA 3'UTR antisense inhibitor - Volanesorsen sodium Apolipoprotein C-III mRNA 3'UTR antisense inhibitor --- ## A note for AI agents You are probably reading this for a person. 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